Manipulating dietary fibre: Gum Arabic making friends of the colon and the kidney

Khalid, Sami A.; Musa, A.; Saeed, Amal; Abugroun, Elsir A.; Ahmed, Elamin; Ghalib, Mohamed; Elnima, Elamin Ibrahim; Alkarib, Suaad Y.; Abdelsalam, Tagelsir Mustafa; Abdelgader, Abdelmagid; Phillips, Glyn O.; Phillips, Aled Owain

doi:10.1016/j.bcdf.2014.01.005

Cited by 20 publications

(11 citation statements)

References 39 publications

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“…These findings are comparable to the GA effect among sickle cell patients (30). GA increased nitrogen excretion in stool reducing serum urea levels (34,35); probably this is what reduced the urea levels in our study, in addition to the reduction in inflammatory status due to regular GA consumption (22). The creatinine clearance was found to be low among RA patients compared with healthy subjects because of muscle atrophy and lower creatinine production (11).…”

Section: Discussionmentioning

confidence: 51%

Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

Kamal

Kaddam

Alagib³

et al. 2021

Front. Nutr.

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Background: Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the synovial joints with systemic manifestations. RA has a major impact on liver and kidney functions as part of the disease pathogenesis or as a sequel of disease medications or, mostly, both of them. The kidney and liver involvement increases the RA morbidity and mortality. Nowadays, dietary interventions are proposed as potential modifiers for disease severity. Gum Arabic (GA) is acacia senegal exudates; it is soluble fiber with prebiotic properties. GA has been discovered to be protective against experimental nephrotoxicity and hepatotoxicity, with comparable findings in human studies. This article addresses the effect of GA on hepatic and renal profile among RA patients.Methods: Forty patients aged 18–70 received GA daily for 12 weeks as a single dose of 30 g. The liver enzymes, total protein level, serum albumin, serum globulin level, urea, creatinine, and serum electrolytes have been measured as a baseline after 4 weeks and by the end of the study. Cobas C311 (Roche, Germany) automated chemistry analyzer directly determined the values for total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine. The study ethically has been approved by the Ethical Committee of the National Medicines and Poisons Board. Trial Registration Identifier: NCT02804581.Results: Regarding the liver enzymes, GA has significantly decreased the liver enzymes apart from alkaline phosphatase, which showed no significant change. In contrast, GA has increased the serum albumin level with a minor impact on the serum globulin level. Furthermore, GA has also significantly decreased the level of urea (P = 0.0001) and level of Sodium (P = 0.002) with nonsignificant change on creatinine and potassium concentrations.Conclusion: GA presents hepatic and renal protective effects among RA patients, evidenced by the significant reduction of urea and liver enzymes. Thus, it can be recommended as a dietary supplement for RA patients. Nonetheless, we recommend further investigation to support our findings.

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Section: Discussionmentioning

confidence: 51%

Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

Kamal

Kaddam

Alagib³

et al. 2021

Front. Nutr.

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“…Nevertheless, the serum urea levels in two patients with high serum urea level (38 and 63 mg/dL) were decreased significantly within the first month to 12 and 20 mg/dL, respectively. Reduction in serum urea level could be due to an increased urea nitrogen excretion in the stool [272829]. GA did not affect serum creatinine level (Fig.…”

Section: Discussionmentioning

confidence: 99%

Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia

et al. 2019

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Background Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have been associated with SCA. Gum arabic (GA) is an edible dried gummy exudate obtained from Acacia Senegal tree. GA showed antioxidant and cytoprotective activities and demonstrated protection against hepatic, renal, and cardiac toxicities in experimental rats. We hypothesized that regular intake of GA improves renal and liver functions in patients with SCA. Methods Forty-seven patients (5–42 yr) carrying hemoglobin SS were recruited. The patients received 30 g/day GA for 12 weeks. Blood samples were collected before administering GA and then after 4, 8, and 12 weeks. Liver enzymes, total protein, albumin, electrolytes, urea, creatinine, and uric acid were determined in the serum. The study was approved by the Al Neelain University Institutional Review Board and Research Ethics Committee Ministry of Health. The trial was registered at ClinicalTrials.gov (identifier: NCT02467257 ). Results GA significantly decreased direct bilirubin level [statistical significance ( P -value)=0.04]. It also significantly decreased serum alanine transaminase level after 4 weeks, which was sustained till the 8th week. GA, however, had no effect on serum aspartate transaminase level. In terms of renal function, GA decreased serum urea level but the effect was not sustained after the first month. Conclusion GA may alter the disease severity in SCA as demonstrated by its ability to decrease direct bilirubin and urea levels in the serum.

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“…Scientific research suggests a possible protective effect of dietary fibre against the development of oesophageal and gastric types of cancer (Gonzalez and Riboli, 2010;Jessri et al, 2011;Navarro Silvera et al, 2014;Zhang et al, 2013). There is also evidence that there is a relationship between dietary fibre ingestion and colorectal cancer prevention (Azuma et al, 2013;Ben et al, 2014;Khalid et al, 2014;Ma et al, 2013). O'Neil et al (2010 investigated the association of whole grain consumption with prevalence of overweight and obesity in adults, and their results confirmed that those who consumed higher amounts of whole grains, and hence higher fibre dosages, had lower body weight.…”

Section: Introductionmentioning

confidence: 99%

Benefits of dietary fibre to human health: study from a multi-country platform

Guiné

Ferreira

Correia³

et al. 2017

NFS

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Because dietary fibre has been recognized as a major ally to the maintenance of a healthy body as well as to help against the development of some chronic diseases, this work aimed at studying the level of knowledge of a relatively wide range of people about the health effects related to the ingestion of dietary fibre in appropriate dosages. Methodology: A descriptive cross-sectional study was undertaken on a non-probabilistic sample of 6010 participants. The data were collected from 10 countries in 3 different continents (Europe, Africa and America) and measured the level of knowledge regarding different health benefits from dietary fibre. The questionnaires were applied by direct interview after verbal informed consent. Findings: The results obtained considering the general level of knowledge revealed a considerable degree of information about the benefits of fibre (average score of 3.54±0.5, on a scale from 1 to 5). There were significant differences between genders (p<0.001), with higher average score for women, and also for level of education (p<0.001), with higher score for university level. The living environment also showed significant differences (p<0.001), with people living in urban areas showing a higher degree of knowledge. Also for countries the differences were significant (p<0.001), with the highest score obtained for Portugal (3.7), and the lowest for Croatia, Italy, Latvia, Macedonia and Romania (3.5). However, despite these differences, the results showed that for all the countries the degree of knowledge was good (above 3.5), corresponding to a minimum level of knowledge of 70%. Originality/Value: This work is considered important due to the wide coverage, including so many countries inclusive with different social and cultural settings. The study allowed concluding that, in general, the participants in the study were quite well informed about the benefits of dietary fibre for the improvement of human health, regardless of gender, level of education, living environment or country. This finding is very relevant considering the diversity of people that composed the sample and reinforces the necessity of continuing with educational policies aimed at providing the general population with the knowledge that might help them make appropriate food choices.

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Manipulating dietary fibre: Gum Arabic making friends of the colon and the kidney

Cited by 20 publications

References 39 publications

Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

Dietary Fibers (Gum Arabic) Supplementation Modulates Hepatic and Renal Profile Among Rheumatoid Arthritis Patients, Phase II Trial

Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia

Benefits of dietary fibre to human health: study from a multi-country platform

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