Manipulating Cardiomyocyte Plasticity for Heart Regeneration

Ko, Toshiyuki; Nomura, Seitaro

doi:10.3389/fcell.2022.929256

Cited by 6 publications

(2 citation statements)

References 162 publications

(192 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The direct conversion of cardiac fibroblasts into induced CMs represents an attractive strategy for cardiac repair and regeneration, with promising potential for clinical applications [96][97][98][99]. PTBP1 (polypyrimidine tract-binding protein 1), also known as hnRNP I, is one of the most characterized repressors of cardiac-specific alternative splicing events [100].…”

Section: Ptbp1 Regulates the Reprogramming Of Cardiac Fibroblasts Int...mentioning

confidence: 99%

RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration

Shi

2023

IJMS

View full text Add to dashboard Cite

Myocardial injury causes death to cardiomyocytes and leads to heart failure. The adult mammalian heart has very limited regenerative capacity. However, the heart from early postnatal mammals and from adult lower vertebrates can fully regenerate after apical resection or myocardial infarction. Thus, it is of particular interest to decipher the mechanism underlying cardiac regeneration that preserves heart structure and function. RNA-binding proteins, as key regulators of post-transcriptional gene expression to coordinate cell differentiation and maintain tissue homeostasis, display dynamic expression in fetal and adult hearts. Accumulating evidence has demonstrated their importance for the survival and proliferation of cardiomyocytes following neonatal and postnatal cardiac injury. Functional studies suggest that RNA-binding proteins relay damage-stimulated cell extrinsic or intrinsic signals to regulate heart regenerative capacity by reprogramming multiple molecular and cellular processes, such as global protein synthesis, metabolic changes, hypertrophic growth, and cellular plasticity. Since manipulating the activity of RNA-binding proteins can improve the formation of new cardiomyocytes and extend the window of the cardiac regenerative capacity in mammals, they are potential targets of therapeutic interventions for cardiovascular disease. This review discusses our evolving understanding of RNA-binding proteins in regulating cardiac repair and regeneration, with the aim to identify important open questions that merit further investigations.

show abstract

Section: Ptbp1 Regulates the Reprogramming Of Cardiac Fibroblasts Int...mentioning

confidence: 99%

RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration

Shi

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…During the progression of HF, the heart gradually loses the ability to replace damaged tissues and regenerate [ 17 ]. Aiming at reactivating cardiomyocytes’ proliferation and restoring the lost myocardial tissue, regenerative medicine efforts for HF deeply differ from current therapeutic strategies that can only delay the ventricular remodeling process and simply postpone the occurrence of end-stage HF.…”

Section: Background/the State Of the Artmentioning

confidence: 99%

Pulmonary Artery Banding for Dilated Cardiomyopathy in Children: Returning to the Bench from Bedside

2022

View full text Add to dashboard Cite

Current treatment paradigms for end-stage dilated cardiomyopathy (DCM) in children include heart transplantation and mechanical support devices. However, waitlist mortality, shortage of smaller donors, time-limited durability of grafts, and thrombo-hemorrhagic events affect long-term outcomes. Moreover, both these options are noncurative and cannot preserve the native heart function. Pulmonary artery banding (PAB) has been reinvented as a possible “regenerative surgery” to retrain the decompensated left ventricle in children with DCM. The rationale is to promote positive ventricular–ventricular interactions that result in recovery of left ventricular function in one out of two children, allowing transplantation delisting. Although promising, global experience with this technique is still limited, and several surgical centers are reluctant to adopt PAB since its exact biological bases remain unknown. In the present review, we summarize the clinical, functional, and molecular known and supposed working mechanisms of PAB in children with DCM. From its proven efficacy in the clinical setting, we described the macroscopic geometrical and functional changes in biventricular performance promoted by PAB. We finally speculated on the possible underlying molecular pathways recruited by PAB. An evidence-based explanation of the working mechanisms of PAB is still awaited to support wider adoption of this surgical option for pediatric heart failure.

show abstract

Novel Approaches in Reversing Environmental Stress Initiated Pathological Processes to Accelerate Organ Repair—The Power of Small Molecules

Bock-Marquette,

Gallyas,

Rendeki

et al. 2024

Advances in Biochemistry in Health and Disease

View full text Add to dashboard Cite

Manipulating Cardiomyocyte Plasticity for Heart Regeneration

Cited by 6 publications

References 162 publications

RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration

RNA-Binding Proteins as Critical Post-Transcriptional Regulators of Cardiac Regeneration

Pulmonary Artery Banding for Dilated Cardiomyopathy in Children: Returning to the Bench from Bedside

Novel Approaches in Reversing Environmental Stress Initiated Pathological Processes to Accelerate Organ Repair—The Power of Small Molecules

Contact Info

Product

Resources

About