Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review

P, Karle Pravin; C, Dhawale Shashikant

doi:10.5530/srp.2019.1.2

Cited by 18 publications

(12 citation statements)

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“…In a review study, the main phytochemical components present in the elaborated extracts were phenolic compounds, represented by gallic acid, catechin, quercetin, kaempferol, chlorogenic acid, p-hydroxybenzoic acid, ellagic acid, ferrulic acid, trans-cinnamic acid (42). Of these, 3 were present in one or more of a chemical form in HEMzL.…”

Section: Rt Min [M-h] -Observed [M-h]mentioning

confidence: 99%

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Freitas

Campina

Costa

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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With the spread of bacterial resistance against clinically used antibiotics, natural plant-derived products are being studied as new sources of antibacterial molecules. Manilkara zapota is a common plant species in the American continent that is used as a food source. Studies show the M. zapota extract is rich in phenolic substances that can serve as basic molecules for the pharmaceutical industry. An extract from fresh M. zapota leaves was produced and tested to identify the compounds present, as well as its direct antibacterial and clinical antibiotic modulatory activities. To analyze the results, a new statistical methodology based on the Shannon-Wiener index was tested, capable of correcting distortions in heterogeneous environments. The Hydroethanolic Extract of Manilkara zapota leaves (HEMzL) presented a wide variety of phenolic products, as well as tannins, in the UPLC analysis. The extract showed direct antibacterial activity against the standard Staphylococcus aureus strain, however, it either acted antagonistically when associated with the tested antibiotics, or it did not present statistical significance when compared to the control. This demonstrates a need to be cautious when associating natural products with antibiotics for clinical use, as a hindrance to infectious treatments may occur. As for the statistical analysis mechanism tested, this proved to be effective, reducing false negatives at low antibiotic concentrations and false positives at high concentrations in the microdilution plate.

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Section: Rt Min [M-h] -Observed [M-h]mentioning

confidence: 99%

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Freitas

Campina

Costa

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…The 70% ethanolic extract has exhibited significant α-glucosidase inhibition by IC 50 value of 104.23 ± 1.75 μg/ml as compared to absolute ethanolic extract. These findings of the moderate αglucosidase inhibitory effects by 70% ethanolic MZFP extract inclined us to believe that it may be attributed to the abundance of the varied extent of phytochemicals in this fruit peel, which includes phenolics like gallic acid, ellagic acid, catechin, quercetin, kaempferol; flavonoids, and other compounds such as alkaloids, tannins, and saponins [31].…”

Section: Discussionmentioning

confidence: 92%

“…The 70% ethanolic extract exhibited the highest of 65.78% inhibition at 50 μg/ml with a least IC 50 value of 32.69 when compared amongst other extracts. These H 2 O 2 scavenging effects by MZFP extracts may attributable to its high contents of total phenolics and other biologically active constituents like gallic acid, ellagic acid, quercetin, and catechin [31]. While extracting phytoconstituents from plant sample, it is critical to recover it with same time and temperature conditions, so the solvents used and type of phytoconstituents in samples are another two most important factors [24].…”

Section: Discussionmentioning

confidence: 99%

Optimization of extraction conditions and evaluation of Manilkara zapota (L.) P. Royen fruit peel extract for in vitro α-glucosidase enzyme inhibition and free radical scavenging potential

et al. 2021

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Background Most of the edible portions like peel and skin of some fruits is discarded while consuming it, though they are rich in several health beneficial phytochemicals or nutrients. Many reports from literature are about fruit pulp of (Sapota) Manilkara zapota (L) P. Royen having high radical scavenging and antioxidant potential, but the studies relating to peel extracts are scanty. Regardless of its commendable phytoconstituents which could have free radical scavenging potential, this fruit peel is as yet still needed to be assessed for in vitro antidiabetic prospects. Hence, the present study aims at evaluating in vitro free radical scavenging and α-glucosidase enzyme hindrance abilities of this fruit peel. Results With a maximum considerable % extractive yield (18.90%) in 70% ethanol, this study has demonstrated that 70% ethanolic extract of Manilkara Zapota (L.) P. Royen Fruit Peel (MZFP) has the highest in vitro free radical scavenging potential as compared to extracts of other solvents viz. n-hexane, chloroform, acetone, absolute ethanol, and water by DPPH and H2O2 assays. In order to optimize the extraction condition parameters, MZFP sample evaluated with three different concentrations of ethanol (40%, 70%, 100%), extraction times (6 h, 9 h, 12 h), and temperatures (40 °C, 50 °C, 60 °C) to get the highest radical scavenging potential. The MZFP when extracted with 70% ethanol, at 50 °C for 12 h, showed higher DPPH (IC50 = 0.34 and 88.42% inhibition at 1 mg/ml) and H2O2 (IC50 = 32.69 and 65.78% inhibition at 50 μg/ml) radical scavenging potential than absolute and 40% ethanolic extracts, when ascorbic acid was used as a reference standard. While further evaluation for in vitro α-glucosidase enzyme inhibition, 70% ethanolic MZFP extract demonstrated high inhibition activity (IC50 = 104.23 ± 1.75 μg/ml) than absolute ethanolic extract (IC50 = 111.65 ± 1.57 μg/ml) with a significant difference (p < 0.05), when acarbose was taken as reference inhibitor (IC50 = 86.93 ± 0.74 μg/ml). Conclusions Overall results indicated that MZFP 70% ethanolic extract exhibited promising in vitro radical scavenging and α-glucosidase enzyme inhibition potential. Thus, suggesting further studies with isolated phytochemicals from peel to explore its potentials for antidiabetic activity through in vitro α-glucosidase enzyme inhibition.

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“…Beberapa jenis tumbuhan obat dengan FL tertinggi diketahui mengandung beberapa komponen senyawa yang berfungsi dalam pengobatan seperti pada tanaman simpur (Dillenia indica) mengandung alkaloid, phenolik, dan flavonoid yang berpotensi sebagai antioksidan (Alam et al, 2020). Sawo (Manilkara zapota) mengandung flavonoid, tanin, phenolik, flavanol, kaempferol (Pravin & Shashikant, 2019), dan pulai (Alstonia scholaris) mengandung alkaloid, flavonoid, tanin, steroid, saponin, dan triterpenoid (Zuraida & Sulistiyani, 2020). Adanya kelompok senyawa bioaktif jenisjenis tumbuhan obat tersebut diduga yang memberikan efek pengobatan terhadap beberapa kategori penyakit yang diderita oleh masyarakat desa Rantau Panjang.…”

Section: Fidelity Level (Fl)unclassified

Local Wisdom of the Rantau Panjang Community, Simpang Hilir District, Kayong Utara Regency in Utilizing Medicinal Plants

Saupi

Yanti

Mariani

et al. 2021

JBT

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Medicinal plants for modern society today are still one of the alternative options in healthcare treatment. This condition is due to the local culture, tradition, and wisdom of a group of people that are still solid and thick. This study aims to analyze the types of medicinal plants used by the community in Rantau Panjang, Simpang Hilir District, North Kayong Regency. This research uses the survey method by conducting interviews with the community and identifying medicinal plants in the field. A sampling of the people who became respondents was done with a purposive sampling technique. The total number of respondents is 333 people distributed in several sub-village, namely Sepakat Jaya 71 people, Tembok Baru 65 people, Ampera 37 people, Makmur 61 people, Sinar Palung 25 people, Kebal Manuk 12 people, Sinar Selatan 35 people and Siput Lestari 27 people. The data obtained were analyzed for Use Value (UV) and Fidelity Level (FL). The village community of Rantau Panjang utilizes 69 types of medicinal plants, with the predominant plant family is Zingiberaceae. The highest use of plant parts is leaves (37.68%), the most common method of processing is boiled (57.97%), and the most extensive way of use is drunk as much as (60.86%). The plants with the highest UV values are turmeric (Curcuma longa L) (0.42), red liyak (Zingiber officinale Linn) (0.34), white turmeric (Curcuma zedoaria L) (0.28), and betel (Piper betle L) (0.22). The types of plants have the highest FL value (100), namely simpur, ketumbar, sawo, leban, pulai, jantung pisang, bunga raya, alalang, durian, nipah, kopi, selo daging, keladi, paku ikan, pegage, kumis kucing, mahkota dewa, belange, belimbing pelunjuk, asam jawa, andong, limau sambal, jambu biji, lidah buaya, pinang, leban, mentimun, daun salam, mentimun, manggis, bajakah, cempedak, pandan wangi, pasak bumi, tebu merah, jengkol, cengkodok, anggrek dan ketepeng.

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Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review

Cited by 18 publications

References 0 publications

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria

Optimization of extraction conditions and evaluation of Manilkara zapota (L.) P. Royen fruit peel extract for in vitro α-glucosidase enzyme inhibition and free radical scavenging potential

Local Wisdom of the Rantau Panjang Community, Simpang Hilir District, Kayong Utara Regency in Utilizing Medicinal Plants

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