Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion

Ko, Yen-Ling; Sun, Chi‐Shu; Chung, Kun-Ming; Lin, Yu‐Min; Feng, I‐Che; Sheu, Ming‐Jen; Koay, Lok-Beng; Lin, Ching‐Yih; Ho, Chung‐Han; Kuo, Hsing‐Tao

doi:10.1371/journal.pone.0117590

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…35 This hypothesis has been confirmed by perihepatic lymph node enlargement in patients with chronic hepatitis B. 36 The low level of HDL-cholesterol induced reactive oxygen species overexpression in DLBCL patients, the investigators found. However, the HDL-cholesterol plays an antiinflammatory role by inhibiting oxidative damage.…”

Section: Discussionmentioning

confidence: 90%

<p>Clinical Analysis and Prognostic Significance of Hepatitis B Virus Infections with Diffuse Large B-Cell Lymphoma</p>

Kang

Han

et al. 2020

CMAR

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Background: China is a high endemic area for the hepatitis B virus (HBV). The studies established the epidemiology between HBV and diffuse large B-cell lymphoma (DLBCL), but further research is necessary to clarify the potential link between HBV and DLBCL. Patients and Methods: A total of 319 patients diagnosed with DLBCL were recruited as cases at First Medical Centre of Chinese PLA General Hospital from September 2010 to December 2018. During the same time, two age-and sex-matched controls were selected for each case, and the control groups comprised of 319 patients with non-hematological malignancy and 319 subjects with non-malignant conditions. Relative risk of developing DLBCL among individuals tested positive for hepatitis B surface antigen was calculated. After that, we retrospectively analyzed clinical data from DLBCL patients with different HBV infection statuses. Results: The HBV infection rate of patients with DLBCL (11.60%) was significantly higher than the other two control groups (5.02% and 4.08%), indicating the risk of DLBCL may increased in HBV infections. Meanwhile, this study demonstrated an independent association between HBV infection and poorer clinical outcomes. Conclusion: Our study demonstrated that HBV infection may play an important role in the pathogenesis of DLBCL and show poor outcomes in HBV-endemic China.

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Section: Discussionmentioning

confidence: 90%

<p>Clinical Analysis and Prognostic Significance of Hepatitis B Virus Infections with Diffuse Large B-Cell Lymphoma</p>

Kang

Han

et al. 2020

CMAR

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“…Inflammatory response in organs usually leads to hyperplasia of regional lymph nodes. Enlarged abdominal lymph nodes are a common finding in patients with chronic active hepatitis [4,5], especially in those caused by autoimmune [6,7] or viral infection [8][9][10]. In addition, a higher incidence of enlarged abdominal lymph nodes in PBC (74-100%) and AIH (13-73%) has been reported [6].…”

Section: Introductionmentioning

confidence: 99%

The Enlargement of Abdominal Lymph Nodes Is a Characteristic of Autoimmune Liver Disease

Wang

Ran

et al. 2020

Mediators of Inflammation

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Background. The enlargement of lymph nodes is a common clinical sign in connective tissue disease (CTD) and viral hepatitis. In this research, we evaluated the incidence of enlarged lymph nodes in autoimmune liver diseases (AILD). Moreover, we identified the clinical significance of abdominal lymph node enlargement in AILD. Methods. The characteristics of abdominal lymph nodes, including their morphology and distribution, were assessed by ultrasonography and computed tomography in 125 patients with AILD, 54 with viral hepatitis, 135 with CTD, and 80 healthy controls. The pathological and laboratory results of 106 AILD patients were collected to analyze the association between lymphadenectasis and disease activity. Results. Enlargement of abdominal lymph nodes was found in 69.6% of patients with AILD, 63% of patients with viral hepatitis, 29.6% of patients with CTD, and 2% of healthy controls. Alkaline phosphatase (ALP), glutamate transpeptidase (GGT), and immunoglobulin M (IgM) levels were significantly increased in AILD patients with lymphadenectasis (LA) in contrast to patients without lymphadenectasis (NLA) (P<0.05). The pathological characteristics of inflammation, cholestasis, and focal necrosis were more common in the LA group than in the NLA group (P<0.05). As shown by multivariate logistic regression analysis, interface hepatitis (OR=3.651, P<0.05), cholestasis (OR=8.137, P<0.05), and focal necrosis (OR=5.212, P<0.05) were related to LA. Conclusions. The percentage of abdominal lymph node enlargement in AILD subjects was significantly higher than that in CTD subjects. Therefore, the enlargement of lymph nodes can represent a noninvasive indicator of histological and biochemical inflammation activity in AILD.

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The differential organogenesis and functionality of two liver-draining lymph nodes in mice

Chen

et al. 2017

Journal of Autoimmunity

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Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion

Cited by 5 publications

References 40 publications

<p>Clinical Analysis and Prognostic Significance of Hepatitis B Virus Infections with Diffuse Large B-Cell Lymphoma</p>

<p>Clinical Analysis and Prognostic Significance of Hepatitis B Virus Infections with Diffuse Large B-Cell Lymphoma</p>

The Enlargement of Abdominal Lymph Nodes Is a Characteristic of Autoimmune Liver Disease

The differential organogenesis and functionality of two liver-draining lymph nodes in mice

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