Manifestations of Human Papillomavirus in the Head and Neck

Dable, Cortney; Nicolli, Elizabeth A.

doi:10.1016/j.mcna.2021.05.007

Cited by 2 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RRP can be diagnosed at any age and is broken down into two categories: the juvenile‐onset form (JoRRP), in which disease is identified before age 12 years, and the adult‐onset form (AoRRP). The role of human papillomavirus (HPV) types 6 and 11 in the pathogenesis of RRP is well‐established 2–5 . HPV‐6 and HPV‐11 RRP‐associated lesions can occur in the pharynx, larynx, and upper respiratory tract, impacting breathing and speech 3 .…”

Section: Introductionmentioning

confidence: 99%

“…The role of human papillomavirus (HPV) types 6 and 11 in the pathogenesis of RRP is well-established. [2][3][4][5] HPV-6 and HPV-11 RRP-associated lesions can occur in the pharynx, larynx, and upper respiratory tract, impacting breathing and speech. 3 However, the main disease burden associated with RRP arises from the tendency of papillomas to recur at multiple sites, necessitating ongoing rounds of treatment and leading to decreased quality of life, with a significant impact on voice, work absenteeism, and financial burden.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interim Results of a Phase 1/2 Open‐Label Study of INO‐3107 for HPV‐6 and/or HPV‐11‐Associated Recurrent Respiratory Papillomatosis

et al. 2023

View full text Add to dashboard Cite

ObjectiveTo evaluate the safety, immunogenicity, and efficacy of INO‐3107, a DNA immunotherapy designed to elicit targeted T‐cell responses against human papillomavirus (HPV) types 6 and 11, in adult patients with recurrent respiratory papillomatosis (RRP; NCT04398433).MethodsEligible patients required ≥2 surgical interventions for RRP in the year preceding dosing. INO‐3107 was administered by intramuscular (IM) injection followed by electroporation (EP) on weeks 0, 3, 6, and 9. Patients underwent surgical debulking within 14 days prior to first dose, with office laryngoscopy and staging at screening and weeks 6, 11, 26, and 52. Primary endpoint was safety and tolerability, as assessed by treatment‐emergent adverse events (TEAEs). Secondary endpoints included frequency of surgical interventions post‐INO‐3107 and cellular immune responses.ResultsAn initial cohort of 21 patients was enrolled between October 2020 and August 2021. Fifteen (71.4%) patients had ≥1 TEAE; 11 (52.4%) were Grade 1, and 3 (14.3%) were Grade 3 (none treatment related). The most frequently reported TEAE was injection site or procedural pain (n = 8; 38.1%). Sixteen (76.2%) patients had fewer surgical interventions in the year following INO‐3107 administration, with a median decrease of 3 interventions versus the preceding year. The RRP severity score, modified by Pransky, showed improvement from baseline to week 52. INO‐3107 induced durable cellular responses against HPV‐6 and HPV‐11, with an increase in activated CD4 and CD8 T cells and CD8 cells with lytic potential.ConclusionThe data suggest that INO‐3107 administered by IM/EP is tolerable and immunogenic and provides clinical benefit to adults with RRP.Level of Evidence3 Laryngoscope, 2023

show abstract

Section: Introductionmentioning

confidence: 99%