Manifestations neuropsychiatriques dans la sclérose en plaques : et si des symptômes psychotiques annonçaient le début de la maladie ?

Guernion, Nathalie; Cadet, Emeline Le; Tirel, Anne; Galudec, Mickaël Le; Edan, Gilles; Walter, Michel

doi:10.1016/j.lpm.2012.10.023

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…and epilepsy are also frequently associated. In some cases, these pathologies are considered a complication directly linked to MS, or even present as a form of early disease presentation [16]. In addition to patients with epilepsy at the time of MS diagnosis, 4.25% of patients develop epilepsy, usually of the focal type, during their lifetime, which is much more frequent than the general prevalence in the non-MS population of 0.5% [11,12].…”

Section: Discussionmentioning

confidence: 99%

Comorbidities in Multiple Sclerosis, Results of a Retrospective Algerian Study

Mouhouche,

Kediha,

pacha

2023

Int. J. Res. Publ. Rev.

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Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). It usually affects young adults and can have dramatic consequences on the functional, emotional and financial course of the patient's life. Comorbidities are common in MS patients. This combination of pathologies causes a decrease in quality of life and long-term disability, further worsening the prognosis of MS.We carried out a retrospective study of the files of 137 patients followed for MS, all forms combined, in specialized consultation at the Neurology department of the University Hospital Mustapha Pasha, during the period between the year 2000 and 2018.The results obtained show that certain comorbidities are more frequent in patients with multiple sclerosis, such as autoimmune pathologies, with a clear predominance of dysthyroidism (19.5%), hypertension and cardiovascular disorders (12.03%). ), ophthalmic diseases (9.77%), psychiatric disorders (depression, anxiety, psychosis, etc.) (7.5%) and epilepsy (5.26%).Several parameters can be affected in the event of association of one or more comorbidities such as diagnostic latency, clinical presentation of MS, acceleration of disability progression, increased mortality and reduced quality of life.Comorbidities complicate the management of patients with multiple sclerosis and have a real impact on their health as well as on the social and economic aspects of their lives. Consequently, a multidisciplinary approach to this pathology and better monitoring remain mandatory.

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Section: Discussionmentioning

confidence: 99%

Comorbidities in Multiple Sclerosis, Results of a Retrospective Algerian Study

Mouhouche,

Kediha,

pacha

2023

Int. J. Res. Publ. Rev.

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“…Moreover, deficits were observed in an MS group with few motor or cognitive deficits, and at a relatively early stage of the disease. Recent studies have documented cases of subjects presenting psychiatric symptoms as inaugural symptoms of MS 57 – 59 . In a princeps fMRI study, Passamonti et al 60 showed that despite the similarity of the performances of MS patients and controls during a facial emotion recognition task, patients showed differences in cerebral activations, suggesting a cerebral process of a compensatory mechanism effective at the clinical/behavioural level but already indicating a deficit of emotional processing at the cerebral level.…”

Section: Discussionmentioning

confidence: 99%

Emotional experience is increased and emotion recognition decreased in multiple sclerosis

Pfaff

Gounot

Chanson

et al. 2021

Sci Rep

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Emotional disorders in multiple sclerosis (MS) are frequently described as difficulties in recognizing facial expressions, rarely in the experience dimension. Moreover, interaction between emotional disorders and cognitive or psychological disorders remains little documented. The aim of this study is to explore emotions in MS in emotion recognition and emotional experience and compare these data with cognitive, psychological, and disease aspects. Twenty-five women with MS (MS group) and 27 healthy controls (control group) matched for age, sex, and education were assessed for emotion recognition (Florida Affect Battery) and emotional experience (International Affective Picture System Photographs). Participants were also assessed for cognitive and psychological aspects. Compared to the control group, the MS group had more difficulty in recognizing emotions, and their subjective evaluations when presented IAPS pictures were more scattered, globally increased. Emotional dimensions were each correlated with executive functions but neither correlated with alexithymia, depression, anxiety, or MS characteristics. In conclusion, MS patients present difficulties in identifying emotion and their emotional experience appears to be increased. These disorders are correlated with cognition but remain independent of psychological or disease aspects. Considering the implications that emotional disorders may have, it seems essential to take these aspects into account in clinical practice.

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