Manifestações mucocutâneas da dengue

Lupi, Omar; Carneiro, Carlos Gustavo; Coêlho, Ivo Castelo Branco

doi:10.1590/s0365-05962007000400002

Cited by 13 publications

(10 citation statements)

References 33 publications

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“…A quick dengue infection confirmation test is not available, and a complete blood count (CBC) might show characteristics such as leukopenia and thrombocytopenia 6 . These findings can be explained by peripheral platelet destruction mechanisms in the liver and spleen via the action of immunocomplexes or the complement system, in addition to the inhibition of medullary hematopoiesis 7 and disseminated intravascular coagulation 8 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Fujimoto

Koifman

2014

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundDengue is an infectious disease with a recurring incidence, especially in developing countries. Despite recent economic growth, success in disease control has not been achieved, and dengue has evolved from cyclic epidemic outbreaks to a lack of seasonality. The lack of scientific basis for the proper management of cases with hemorrhagic manifestations, especially regarding transfusion procedures, might contribute to the high death rate in potentially avoidable cases.ObjectiveThe aim of the study was to identify the clinical and laboratory manifestations in hemorrhagic dengue fever treated at the emergency services in Rio Branco, AC, Brazil, as well as to describe transfusion characteristics of patients and identify possible prognostic factors.MethodsA retrospective descriptive study was performed to analyze the distribution of relative frequencies of clinical and laboratory variables. The study was carried out in Rio Branco with confirmed dengue fever cases. Secondary data were obtained by Acre Epidemiological Surveillance teams of cases with bleeding or platelet counts under 100.0 × 109/L. The patients' clinical, laboratory and transfusion data were obtained from hospital records.ResultsA total of 90,553 dengue cases were reported of which 7,447 had serologic confirmation; 267 cases had hemorrhagic manifestations and 193 patients were located. Nearly half of the patients had anemia and the mean of the lowest platelet count of these patients was 26.4 × 109/L. Platelet concentrate was transfused in 22.3% of cases with a mean of 7.5 IU/patient, fresh frozen plasma in 21.2% with a mean of 5.2 IU/patient and just 2.6% of patients received concentrated red blood cells with a mean of 3.2 IU/patient. Bleeding led to transfusions. Signs of plasma leakage and cardiopulmonary dysfunction were correlated to unfavorable outcomes.ConclusionThe pattern of clinical and laboratory criteria observed in this investigation does not differ from the literature. Transfusions were used as part of the treatment of dengue hemorrhagic fever manifestations. Some of the clinical manifestations may be related to unfavorable outcomes.© 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Fujimoto

Koifman

2014

Revista Brasileira de Hematologia e Hemoterapia

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“…O vírus tem um segundo ciclo de replicação, nesse momento dentro de monócitos, macrófagos e célu-las musculares, explicando a intensa mialgia descrita em vários casos 3 . A replicação viral induz a produção de citocinas por parte dos macrófagos, como o fator de necrose tumoral alfa (TNF-α) e a interleucina (IL)6.…”

Section: Discussionunclassified

“…A replicação viral induz a produção de citocinas por parte dos macrófagos, como o fator de necrose tumoral alfa (TNF-α) e a interleucina (IL)6. A partir da liberação destas citocinas é que, provavelmente, dá-se o início do mal estar e quadro febril no paciente 3,7 . Do mesmo modo, tais substâncias estão fortemente relacionadas ao mecanismo de desenvolvimento de dor inflamatória, diminuindo o limiar álgico, causando hipernocicepção 8 .…”

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Avaliação de manifestações dolorosas em pacientes internados em hospital de referência, com diagnóstico provisório de dengue

Ponte¹,

Pucci²,

Filho³

et al. 2011

Rev. dor

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“…Essa etapa é denominada viremia, ou seja, o vírus está presente no sangue e no mosquito e depois transmitirá para o ser humano no período entre seis a oito semanas (SUCEN, 2000). A fase de incubação do vírus é de cinco a seis dias, embora se possa prolongar por até 15 (LUPI et al, 2007 Após caracterizar o mosquito transmissor da dengue, apresenta-se a metodologia utilizada para esse estudo.…”

Section: Caracterização Do Mosquito Transmissorunclassified

Dengue No Brasil: Gestão De Políticas Públicas De Controle E Erradicação

et al. 2016

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Resumo:A dengue é uma doença endêmica que se transformou em um dos maiores problemas de saúde pública no mundo. Nesse contexto, este estudo tem como escopo analisar o panorama das políticas públicas, referente ao controle e erradicação da dengue, através do levantamento dos casos de contágio nos anos de 2004 a 2014. Após a análise, conclui-se que a falta de informação, a ausência de campanhas de educação ambiental, a rápida proliferação do mosquito e a inexistência de ações governamentais proativas de prevenção, estão entre os principais fatores que ensejam a vulnerabilidade de algumas políticas públicas, mesmo em regiões com vultosas disponibilidades de recursos orçamentários para combater a doença.Palavras-chave: Gestão Pública. Políticas Públicas. Dengue. Aedes aegypti. DENGUE IN BRAZIL: MANAGEMENT OF PUBLIC POLICIES OF CONTROL AND ERADICATIONAbstract: Dengue is an endemic disease that has become one of the major public health problems in the world. In this context, this study has the aim to analyze the panorama of public policies regarding the control and eradication of dengue through the survey of infection cases from 2004 to 2014. After the analysis, we can conclude that the lack of information, the absence of environmental education campaigns, the rapid proliferation of mosquitoes, and the inexistence of proactive governmental prevention actions are among the

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Manifestações mucocutâneas da dengue

Cited by 13 publications

References 33 publications

Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

Avaliação de manifestações dolorosas em pacientes internados em hospital de referência, com diagnóstico provisório de dengue

Dengue No Brasil: Gestão De Políticas Públicas De Controle E Erradicação

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