Manifestaciones cardiacas en la etapa aguda de la enfermedad de Kawasaki en un hospital pediátrico de tercer nivel en la Ciudad de México

Garrido-Garcı́a, Luis Martı́n; Peña-Juárez, Rocío A.; Yamazaki‐Nakashimada, Marco Antonio

doi:10.1016/j.acmx.2018.03.005

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…El INP es el hospital que más casos tiene registrados y demuestra en diferentes periodos cómo han incrementado los casos nuevos de EK: con 48 casos de 1995 a 2003; 108 casos de 2004 a 2008; 182 casos de 2009 a 2013; 170 casos de 2014 a 2016; y 179 casos de 2017 a 2019. 8,13,14 A pesar de que se trata de un único…”

Section: Discussionunclassified

Enfermedad de Kawasaki, casos diagnosticados en dos hospitales pediátricos en México de enero de 2004 a marzo de 2020

García-Domínguez¹,

Quibrera²,

Canizales-Muñoz³

et al. 2021

Alergia, Asma E Inmunología Pediátricas

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Introducción: La enfermedad de Kawasaki (EK) es una vasculitis de pequeños y medianos vasos, que afecta principalmente a menores de cinco años de edad; su etiología es desconocida, se caracteriza por un síndrome febril agudo con manifestaciones mucocutáneas y puede desarrollar anormalidades de las arterias coronarias (AAC). El tratamiento con inmunoglobulina intravenosa (IGIV) y aspirina previene las AAC y otras complicaciones. Objetivo: Describir las características epidemiológicas, clínicas, tratamiento y complicaciones de la EK en dos hospitales pediátricos en el noroeste del país a lo largo de 16 años. Material y métodos: Estudio retrospectivo de pacientes con EK en dos centros pediátricos. Se obtuvo la frecuencia de los pacientes con diagnóstico de EK completo y EK incompleto. Los resultados se representaron como media, desviación estándar y mediana, según la variable correspondiente. Resultados: Un total de 62 pacientes con EK, el sexo masculino fue de 64.5%, la mediana de edad a diagnóstico de 33.4 meses. La fiebre, rash y conjuntivitis se ABSTRACT Introduction: Kawasaki disease (KD) is a small and medium vessel vasculitis, that mainly affects patients under 5 years age, of unknown etiology, characterized by an acute febrile syndrome with mucocutaneous manifestations and develop coronary artery abnormalities (CAA). Treatment with Intravenous immunoglobulin (IVIG) and aspirin prevent to CAA and other complications. Objective: To known the epidemiological, clinical characteristics, treatment and complications of KD in two pediatric centers in the northwest of the Mexico in the course of 16 years. Material and methods: Retrospective study of patients with KD in two pediatric centers. The frecuency of patients with a diagnosis of complete and incomplete KD was obtained. The results were represented as mean, standard desviation and median, according to corresponding variable. Results: We report 62 patients with KD. Males were 64.5%, the median age at the time of diagnosis were 33.4 months. Predominant clinical manifestations were fever, rash and conjunctivitis in more than 86% of cases. Incomplete KD Enfermedad de Kawasaki, casos diagnosticados en dos hospitales pediátricos en México de enero de 2004 a marzo de 2020 Kawasaki disease, cases diagnosed in two pediatric hospitals in Mexico from

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Section: Discussionunclassified

Enfermedad de Kawasaki, casos diagnosticados en dos hospitales pediátricos en México de enero de 2004 a marzo de 2020

García-Domínguez¹,

Quibrera²,

Canizales-Muñoz³

et al. 2021

Alergia, Asma E Inmunología Pediátricas

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“…In Mexico as well in other Latin American countries, KD is underdiagnosed and there are only isolated reports of the disease (6). However, the number of cases of KD in Mexico has been increasing over the years 1 (7,8). KD is a disease of young children, with almost 80% of the cases diagnosed before 5 years of age (9).…”

Section: Discussionmentioning

confidence: 99%

Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale

et al. 2020

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Background: Kawasaki disease (KD) is an acute febrile illness that largely affects young children before 5 years of age. Younger children with KD are reported to have a higher prevalence of coronary artery abnormalities. Little is known about infants in the first 3 months of age diagnosed with KD. Methods: A retrospective study was conducted at the National Institute of Pediatrics in Mexico City from 1995 to 2019. Clinical features, laboratory results and cardiac outcomes were recorded. Infants in the first 3 months of age were compared with older patients. Wilcoxon-Mann-Whitney analysis was performed for continuous variables and Fisher's exact test for categorical variables. Results: Six hundred and eighty-eight cases of KD were included in this study. Fourteen cases were diagnosed in the first three months of age. Heart failure and KD shock-syndrome was found in five cases (35.7%). Giant coronary artery aneurysms were found in six cases in the younger group (42.9%). Conclusions: Diagnosis of KD in children younger than 3 months of age is rare. In most cases, an incomplete presentation contributed to a delay diagnosis, treatment, and complications. Younger patients with KD have an increased risk of presenting cardiac complications, including giant coronary artery aneurysms, shock, and death.

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Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

Liu

Qiu

et al. 2020

Eur J Clin Investigation

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Background Kawasaki disease (KD) is an acute, self‐limited vasculitis. Coronary artery aneurysm (CAA) serves as a major contributor to the long‐term prognosis of KD. In addition, acute KD usually also leads to several kinds of noncoronary cardiac abnormalities (NCA) involving the pericardium, myocardium and endocardium. Materials and methods A total of 142 Chinese children with KD were recruited from July 2015 to April 2018. Blood samples were collected at 24 hours pre‐intravenous immunoglobulin (IVIG) therapy. Several inflammatory mediators and biomarkers for acute myocardial infarction were detected. Echocardiography and electrocardiography (ECG) were performed. Results Plasma white blood cell counts (WBC) were significantly increased in patients with IVIG‐nonresponsive KD when compared with their IVIG‐responsive counterparts. A total of 106 children (74.65%) suffered from NCA, including 8 patients (5.63%) with pericardial effusion, 23 patients (16.20%) with acute myocarditis, 101 patients (71.13%) with valvular regurgitation and 8 patients (5.63%) with abnormal ECG. No significant differences were observed in the distribution of clinical classification and the response to IVIG therapy regardless of NCA exhibited or not. Conclusions Noncoronary cardiac abnormalities is almost universal in acute KD and mainly manifests as valvular regurgitation. However, it has no influence on clinical classification and the response to IVIG therapy.

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Manifestaciones cardiacas en la etapa aguda de la enfermedad de Kawasaki en un hospital pediátrico de tercer nivel en la Ciudad de México

Abstract: There has been an increase in the diagnosis of Kawasaki disease in Mexico. They presented with more cardiac complications than reported in literature. An increased knowledge of Kawasaki disease is required in Mexico in order to establish the cardiac outcomes of this group of patients.

Cited by 3 publications

References 28 publications

Enfermedad de Kawasaki, casos diagnosticados en dos hospitales pediátricos en México de enero de 2004 a marzo de 2020

Enfermedad de Kawasaki, casos diagnosticados en dos hospitales pediátricos en México de enero de 2004 a marzo de 2020

Kawasaki Disease in Infants in the First 3 Months of Age in a Mexican Population: A Cautionary Tale

Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

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