Manifestación laríngea de linfoma no Hodgkin de células B

Guilarte, Jhonder Xavier Salazar; Méstre, Manuela Sancho; Albert, Juan Ramón Gras

doi:10.1016/j.otorri.2011.04.007

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Systemic symptomatology is unusual, since laryngeal lymphomas tend to remain localized for prolonged periods, though more aggressive forms tend to spread earlier [10]. Interestingly, these tumors usually spread to other mucosal sites such as bowel, lung, and orbit rather than nodal sites [7] [8].…”

Section: Discussionmentioning

confidence: 99%

Primary Lymphoma of the Larynx: A Case Report and Literature Review

Khamassi¹,

Mahfoudhi²,

Jaafoura³

et al. 2015

OJCD

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Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

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Section: Discussionmentioning

confidence: 99%

Primary Lymphoma of the Larynx: A Case Report and Literature Review

Khamassi¹,

Mahfoudhi²,

Jaafoura³

et al. 2015

OJCD

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Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis

Kim

Woo

2015

The Laryngoscope

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Laryngeal Extranodal Nasal-type Natural Killer/T-cell Lymphoma

Xiang

Chen

Zhao

et al. 2019

American Journal of Surgical Pathology

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Extranodal natural killer/T-cell lymphoma, nasal-type (ENKTL-N) initially presented in larynx is a rare condition without distinctive clinicopathologic features, with a challenging pathologic diagnosis. This study aimed to evaluate the clinicopathologic features and diagnosis of laryngeal ENKTL-N and spread awareness regarding ENKTL-N. A series of 31 cases of laryngeal ENKTL in one Chinese institution over a 9-year interval was retrospectively analyzed. Median age was 50 years (range, 13 to 77 y) with a male/female ratio of 5.2:1 (26/5). All patients initially presented with hoarseness and/or laryngalgia, and 10 patients (32.3%) experienced B symptoms. The supraglottic region was the most common site of occurrence (58.1%), the glottic area being the rarest site (6.5%). The mucosal squamous epithelium was detected in 26 specimens and pseudoepitheliomatous hyperplasia was observed in 8 cases (8/26, 30.8%). “Keratin-pearls” and a “pseudoinvasive” pattern were observed in 2 cases. Follow-up data were available for 26 patients (83.9%), the median survival duration was 9 months, and the overall survival rate at 5 years was 29.6%. Univariate analysis revealed that patients experiencing B symptoms (P=0.019) and age above 60 years had a significantly low survival (P=0.049) and that combined radiotherapy and chemotherapy prolongs overall survival (P<0.001). Laryngeal ENKTL-N is a rare entity with high aggressiveness and a poor prognosis. Multiple biopsies are usually required owing to secondary infection and massive necrosis. Laryngeal EKTL-N may mimic inflammatory lesions or well-differentiated squamous cell carcinoma. Therefore, clinical vigilance is essential to prevent misdiagnosis or a delayed diagnosis.

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Manifestación laríngea de linfoma no Hodgkin de células B

Cited by 4 publications

References 9 publications

Primary Lymphoma of the Larynx: A Case Report and Literature Review

Primary Lymphoma of the Larynx: A Case Report and Literature Review

Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis

Laryngeal Extranodal Nasal-type Natural Killer/T-cell Lymphoma

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