Manic Induction with Interferon Alpha Therapy

Goh, Timothy; Dhillon, Rohan; Bastiampillai, Tarun

doi:10.3109/00048674.2011.615296

Cited by 1 publication

(1 citation statement)

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“…Additionally, a study conducted by Quarantini and colleagues demonstrated that patients with HCV infection exhibit cognitive impairment, especially over visuo-spatial memory performance, which may be specific to HCV infection rather than secondary psychiatric comorbidities [ 22 ]. Even though a case report demonstrated interferon therapy could induce mania [ 23 ], limited evidence investigated the association between HBV/HCV and subsequent BD. To test these hypothesis that HBV or HCV infection is associated with subsequent BD, we conducted a nationwide, population-based cohort study to investigate whether HBV or HCV infection increases the risk of BD.…”

Section: Introductionmentioning

confidence: 99%

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

et al. 2018

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BackgroundBipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent mood fluctuations. This study aims to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for BD.MethodsA total of 48,215 patients with newly diagnosed viral hepatitis from 2000 to 2010 were identified and frequency-matched with 192,860 people without hepatitis. Both groups were followed until diagnosis with BD, withdrawal from the national health insurance program, or the end of 2011. Patients with viral hepatitis were grouped into 3 cohorts: HBV infection, HCV infection, and HBV/HCV coinfection. The association between viral hepatitis and BD were examined using Cox proportional hazards regression models.ResultsThe incidence of BD was higher in HBV/HCV coinfection than in the control group, with an adjusted hazard ratio of 2.16 (95% confidence interval 1.06–4.41) when adjusted for sex, age, and comorbidity. After further adjustment, we noted that an age more than 65 years and female may be associated with an increased risk of BD in patients with chronic hepatitis B and C.ConclusionViral hepatitis may be associated with increased risk of subsequent BD.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1542-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%