Mania-Like Symptoms Suggestive of Childhood-Onset Bipolar Disorder in Clinically Referred Children

Wozniak, Janet; Biederman, Joseph; Kiely, Kathleen; Ablon, J. Stuart; Faraone, Stephen V.; Mundy, Elizabeth; Mennin, Douglas S.

doi:10.1097/00004583-199507000-00010

Cited by 642 publications

(532 citation statements)

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“…16,[44][45][46] A high comorbidity has been reported between ADHD and BD, more specifically with early-onset BD. 47 Therefore, our results suggest that SNAP25 might be a common susceptibility factors for these psychiatric disorders. These data are strengthened by the recent results obtained by Kim et al, 48 showing that comorbidity with major depressive disorder may enhance detection of the association between SNAP25 and ADHD.…”

Section: Discussionmentioning

confidence: 63%

A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain

et al. 2009

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Bipolar disorder (BD) is one of the most common and persistent psychiatric disorders. Earlyonset BD has been shown to be the most severe and familial form. We recently carried out a whole-genome linkage analysis on sibpairs affected by early-onset BD and showed that the 20p12 region was more frequently shared in our families than expected by chance. The synaptosomal-associated protein SNAP25 is a presynaptic plasma membrane protein essential for the triggering of vesicular fusion and neurotransmitter release, and for which abnormal protein levels have been reported in postmortem studies of bipolar patients. We hypothesised that variations in the gene encoding SNAP25, located on chromosome 20p12, might influence the susceptibility to early-onset BD. We screened SNAP25 for mutations and performed a case-control association study in 197 patients with early-onset BD, 202 patients with late-onset BD and 136 unaffected subjects. In addition, we analysed the expression level of the two SNAP25 isoforms in 60 brains. We showed that one variant, located in the promoter region, was associated with early-onset BD but not with the late-onset subgroup. In addition, individuals homozygous for this variant showed a significant higher SNAP25b expression level in prefrontal cortex. These results show that variations in SNAP25, associated with an increased gene expression level in prefrontal cortex, might predispose to early-onset BD. Further analyses of this gene, as well as analysis of genes encoding for the SNAP25 protein partners, are required to understand the impact of such molecular mechanisms in BD.

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Section: Discussionmentioning

confidence: 63%

A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain

et al. 2009

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“…Juvenile BPD in its various forms affects from 1-4% of pediatric groups (Lewinsohn, et al, 1995) with up to one-fifth of psychiatrically referred children and adolescent psychiatric outpatients manifesting BPD (Weller, et al, 1986, Wozniak, et al, 1995. The literature also documents the concurrent, face, and predictive validity of BPD in childhood (Biederman, et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…The literature also documents the concurrent, face, and predictive validity of BPD in childhood (Biederman, et al, 2003). Recent work suggests that pediatric onset BPD may represent a unique developmental type of BPD characterized by a chronic course, mixed presentations, and high levels of severe irritability , Biederman, et al, 2003, Carlson, 1984, Geller, et al, 2006, Geller, et al, 2004, Wozniak, et al, 1995. For instance, two ongoing multisite, National Institute of Mental Health (NIMH) funded studies show that children and adolescents with BPD maintain a functionally impaired status characterized by a highly relapsing and remitting course , Birmaher, 2004, Geller, et al, 2006, Geller, et al, 2004.…”

Section: Introductionmentioning

confidence: 99%

“…Systematic studies of BPD children have found high rates of attention-deficit/Hyperactivity Disorder (ADHD), anxiety disorders (panic, and obsessive compulsive disorder) (Geller, et al, 1995, 1998b, 2000, Strober, et al, 1998, West, et al, 1996, Wozniak, et al, 1995, and conduct disorder (CD) , Carlson, et al, 1998, Geller, et al, 1995, 2000, Kovacs and Pollock, 1995. Among the most concerning comorbidities in juvenile onset BPD is the link with cigarette smoking and substance use disorders (SUD; including drug or alcohol abuse or dependence).…”

Section: Introductionmentioning

confidence: 99%

“…One of the most frequent comorbidities in BPD is conduct disorder (CD) , Kovacs and Pollock, 1995, Wozniak, et al, 1995 . Since CD is a well known risk factor for early-onset SUD (Brook, et al, 1995, Carlson, et al, 1998, Tarter, et al, 1990, Whitmore, et al, 1997, a thorough examination of putative associations between BPD and SUD requires careful evaluation of the influence of comorbid CD.…”

Section: Introductionmentioning

confidence: 99%

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