Mangiferin: the miraculous xanthone with diverse pharmacological properties

Dutta, Tusheema; Das, Tuyelee; Gopalakrishnan, Abilash Valsala; Saha, Suman; Ghorai, Mimosa; Nandy, Samapika; Kumar, Manoj; Radha, .; Ghosh, Arabinda; Mukerjee, Nobendu; Dey, Abhijit

doi:10.1007/s00210-022-02373-6

Cited by 15 publications

(30 citation statements)

References 99 publications

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Section: Introductionmentioning

confidence: 99%

“…Mangiferin, first isolated from the bark and leaves of the mango tree ( Mangifera indica L.), is a natural xanthonoid polyphenol belonging to the xanthone family of secondary metabolites with various structures ( Dutta et al ., 2023 ; Mei et al ., 2023 ). Although the absorption rate and oral bioavailability are too low, clinical application is not currently achieved, mangiferin has excellent potential as a nutraceutical material due to its various biological activities ( Remali et al ., 2022 ; Dutta et al ., 2023 ). Accumulated studies have reported that mangiferin possesses a wide range of pharmacological properties, including antidiabetic, neuroprotective, cardiotonic, immunomodulatory, antiallergic, renoprotective, antithrombotic, memory enhancing and anti-cancer effects ( Walia et al ., 2021 ; Lum et al ., 2022 ; Wang et al ., 2022b ).…”

Section: Introductionmentioning

confidence: 99%

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Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage

Park,

Cha,

Hwangbo

et al. 2024

Biomol Ther (Seoul)

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Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study aimed to evaluate whether mangiferin could protect human RPE ARPE-19 cells from oxidative injury mimicked by hydrogen peroxide (H 2 O 2 ). The results showed that mangiferin attenuated H 2 O 2 -induced cell viability reduction and DNA damage, while inhibiting reactive oxygen species (ROS) production and preserving diminished glutathione (GSH). Mangiferin also antagonized H 2 O 2 -induced inhibition of the expression and activity of antioxidant enzymes such as manganese superoxide dismutase and GSH peroxidase, which was associated with inhibition of mitochondrial ROS production. In addition, mangiferin protected ARPE-19 cells from H 2 O 2 -induced apoptosis by increasing the Bcl-2/Bax ratio, decreasing caspase-3 activation, and blocking poly(ADP-ribose) polymerase cleavage. Moreover, mangiferin suppressed the release of cytochrome c into the cytosol, which was achieved by interfering with mitochondrial membrane disruption. Furthermore, mangiferin increased the expression and activity of heme oxygenase-1 (HO-1) and nuclear factor-erythroid-2 related factor 2 (Nrf2). However, the inhibition of ROS production, cytoprotective and anti-apoptotic effects of mangiferin were significantly attenuated by the HO-1 inhibitor, indicating that mangiferin promoted Nrf2-mediated HO-1 activity to prevent ARPE-19 cells from oxidative injury. The results of this study suggest that mangiferin, as an Nrf2 activator, has potent ROS scavenging activity and may have the potential to protect oxidative stress-mediated ocular diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage

Park,

Cha,

Hwangbo

et al. 2024

Biomol Ther (Seoul)

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“…Mangiferin is a natural compound that is generally considered safe, with no reported adverse effects in humans. Many studies on mangiferin have been conducted in animal models ( Lum et al, 2021 ; Dutta et al, 2023 ). The studies presented here seek to explain the direct inhibitory effect of the naturally occurring plant-based bioactive compound—mangiferin—on LDH activity and provide a spotlight on the compound's potential medical applications, particularly in oncotherapy.…”

Section: Introductionmentioning

confidence: 99%

Recombinant production, purification, and biochemical characterization of a novel L-lactate dehydrogenase from Bacillus cereus NRC1 and inhibition study of mangiferin

Esa

El-Sayed

El-Khonezy

et al. 2023

Front. Bioeng. Biotechnol.

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Lactate dehydrogenase (LDH, EC 1.1.1.27) is one of the vital glycolytic conditions, especially during anaerobic conditions. It is a significant diagnostic, prognostic, and monitoring biomarker parameter. A 950-bp DNA fragment containing the gene (LDH) encoding LDH was amplified from Bacillus cereus NRC1. The deduced amino acid sequence reveals that B. cereus LDH (Bc-LDH) is highly homologous to the LDHs of Bacillus organisms. All LDH enzymes have a significant degree of conservation in their active site and several additional domains with unidentified functions. The gene for LDH, which catalyzes lactate synthesis, was cloned, sequenced (accession number: LC706200.1), and expressed in Escherichia coli BL21 (DE3). In this investigation, Bc-LDH was purified to homogeneity with a specific activity of 22.7 units/mg protein and a molecular weight of 35 kDa. It works optimally at pH 8.0. The purified enzyme was inhibited by FeCl2, CuCl2, ZnCl2, and NiCl, whereas CoCl2 was found to boost the activity of Bc-LDH. The molecular docking of the 3D model of the Bc-LDH structure with a natural inhibitor, mangiferin, demonstrated excellent LDH inhibition, with a free binding energy of −10.2 kcal/mol. Moreover, mangiferin is a potent Bc-LDH inhibitor that inhibits Bc-LDH competitively and has one binding site with a Ki value of 0.075 mM. The LDH-mangiferin interaction exhibits a low RMSF value (>1.5 Å), indicating a stable contact at the residues. This study will pave the way for more studies to improve the understanding of mangiferin, which could be considered an intriguing candidate for creating novel and improved LDH inhibitors.

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“…All four of Lipinski's criteria, i.e., the molecular mass of less than 500 Da, high lipophilicity, less than five hydrogen bond donors and fewer than ten hydrogen bond acceptors, are satisfied by the chemical makeup of MGF when taken orally. Numerous pathophysiological traits of MGF imply that it might make an effective therapeutic [22]. MGF is a potent antioxidant with incredible therapeutic benefits, including analgesic, antiviral, anticancer, antidiabetic, antioxidant, antiaging and immunomodulatory activities [23].…”

Section: Introductionmentioning

confidence: 99%

“…All four of Lipinski’s criteria, i.e., the molecular mass of less than 500 Da, high lipophilicity, less than five hydrogen bond donors and fewer than ten hydrogen bond acceptors, are satisfied by the chemical makeup of MGF when taken orally. Numerous pathophysiological traits of MGF imply that it might make an effective therapeutic [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy

Sarfraz,

Khan,

Batiha

et al. 2023

Cancers

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Mangiferin (MGF), a xanthone derived from Mangifera indica L., initially employed as a nutraceutical, is now being explored extensively for its anticancer potential. Scientists across the globe have explored this bioactive for managing a variety of cancers using validated in vitro and in vivo models. The in vitro anticancer potential of this biomolecule on well-established breast cancer cell lines such as MDA-MB-23, BEAS-2B cells and MCF-7 is closer to many approved synthetic anticancer agents. However, the solubility and bioavailability of this xanthone are the main challenges, and its oral bioavailability is reported to be less than 2%, and its aqueous solubility is also 0.111 mg/mL. Nano-drug delivery systems have attempted to deliver the drugs at the desired site at a desired rate in desired amounts. Many researchers have explored various nanotechnology-based approaches to provide effective and safe delivery of mangiferin for cancer therapy. Nanoparticles were used as carriers to encapsulate mangiferin, protecting it from degradation and facilitating its delivery to cancer cells. They have attempted to enhance the bioavailability, safety and efficacy of this very bioactive using drug delivery approaches. The present review focuses on the origin and structure elucidation of mangiferin and its derivatives and the benefits of this bioactive. The review also offers insight into the delivery-related challenges of mangiferin and its applications in nanosized forms against cancer. The use of a relatively new deep-learning approach to solve the pharmacokinetic issues of this bioactive has also been discussed. The review also critically analyzes the future hope for mangiferin as a therapeutic agent for cancer management.

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Mangiferin: the miraculous xanthone with diverse pharmacological properties

Cited by 15 publications

References 99 publications

Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage

Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage

Recombinant production, purification, and biochemical characterization of a novel L-lactate dehydrogenase from Bacillus cereus NRC1 and inhibition study of mangiferin

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy

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