Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals

Abstract

Mangiferin (MGF) is a polyphenolic C‐glucosyl‐xanthone extracted from the mango tree (Mangifera indica). MGF has shown diverse effects such as antioxidant, antiapoptotic, radical scavenging, and chelating properties. MGF also has been shown to modulate inflammatory pathways. In this review, we examined and evaluated the literature dealing with the protective effects of MGF against various chemical toxicities. Our literature review indicated that the MGF‐induced protective effects against the toxic effects of pharmaceuticals, heavy metals and environmental chemicals were mainly mediated via suppression of lipid peroxidation, oxidative stress (along with enhancement of the antioxidant enzyme), inflammatory factors (TNF‐α, IL‐6, IL‐10, and IL‐12), and activation of PI3K/Akt and the MAPK survival signaling pathway.

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

“…Moreover, considering that IL-6 is under the transcriptional regulation of NF-kB [ 57 , 58 , 59 ], immunofluorescence staining was performed to assess the level of NF-kB in HaCaT pre-treated with MG and exposed to CS. In particular, HaCaT cells were treated with E, TE5, E-MG, and TE5-MG, comparing the efficacy of entrapped MG to that of Sol-MG, quantified with respect to untreated cells (CTRL).…”

Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation

“…MF is one of the main components derived from mango fruits, which has been extensively used because it displays hypotoxicity and owns a broad spectrum pharmacological properties including anti-inflammatory anti-diabetic, anti-oxidative, anti-aging, anti-viral and anti-cancer effects. 10 For example, in arsenic-induced lung injury, MF suppressed inflammatory cell infiltration and restored the antioxidant balance by upregulating Nrf2-HO1 signaling pathway. 17 In human ovarian carcinoma OVCAR3 cells, MF significantly decreased viability of cancer cells, and increased the sensitivity of cancer cells to cisplatin.…”

“… 8 MF possesses multiple pharmacologic properties including antidiabetic, anti-inflammatory, antiviral, antioxidative, antiaging, immunomodulatory, cardioprotective and analgesic effects. 9 , 10 In particular, MF also displays potent inhibitory effect on NLRP3 inflammasome in some certain diseases. For instance, MF could relieve blast-induced traumatic brain injury by inactivating NLRP3 inflammasome.…”

Improving Aqueous Solubility of Natural Antioxidant Mangiferin through Glycosylation by Maltogenic Amylase from Parageobacillus galactosidasius DSM 18751

“…2 The folds of the aqueous solubilities of the mangiferin glucoside derivatives are expressed as relative to that Mangiferin exhibits a wide pharmacological profile, and its antioxidant property is well known from previous studies. Furthermore, it has been associated with the redox aromatic system of the xanthone nucleus [3][4][5][6][7][8][9][10]12]. Thus, the antioxidative activities of the two mangiferin glucosides were determined using DPPH free radical scavenging assay.…”

“…Mangiferin has been reported to possess diverse health-promoting activities, such as antioxidant [1,2], anticancer [3,4], anti-inflammatory [5], and anti-osteoarthritis pain activities [6], allowing it to prevent memory impairment [7], neurodegeneration [8], and organ fibrosis [9]. Furthermore, it offers protection from the deleterious effects of heavy metals [10]. However, the pharmacological use of mangiferin is restricted owing to its poor solubility and low bioavailability [11,12].…”