Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway

Li, Haowen; Lan, Taijin; Yun, Chenxia; Yang, Kun; Du, Zhenhong; Luo, Xue-fei; Hao, Erhong; Deng, Jiagang

doi:10.1016/j.chmed.2019.12.002

Cited by 18 publications

(8 citation statements)

References 76 publications

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“…Consistent ex vivo evidence focussing on the hippocampus also shows that mangiferin can protect rodent neuronal tissue from the increase in inflammatory cytokines [9,[30][31][32] and the decrease in neurotrophins such as brain-derived neurotrophic factor (BDNF) [9,31], associated with multifarious brain insults. Similarly, mangiferin has been shown to protect the rodent brain from lead-induced structural damage and decrease oxidative stress via interactions within the Nrf2 signalling pathways in rats [10].…”

Section: Introductionmentioning

confidence: 99%

“…This group of polyphenols are found in a restricted group of plant species [ 3 ], including members of the Hypericum genus that provide us with a number of medicinal herbal extracts [ 4 ], but they are rarely consumed in the diet, with only a few exceptions other than mango itself (e.g., [ 5 ]). The predominant member of this structural group in mango leaf is mangiferin, a xanthone glucoside that has been shown to have potential anti-inflammatory, antioxidant, immunomodulatory, neuroprotective, antiproliferative, antidiabetic, DNA protective, and hypoglycaemic properties [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

et al. 2020

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Extracts made from the leaves of the mango food plant (Mangifera indica L., Anacardiaceae) have a long history of medicinal usage, most likely due to particularly high levels of the polyphenol mangiferin. In rodent models, oral mangiferin protects cognitive function and brain tissue from a number of challenges and modulates cerebro-electrical activity. Recent evidence has confirmed the latter effect in healthy humans following a mangiferin-rich mango leaf extract using quantitative electroencephalography (EEG). The current study therefore investigated the effects of a single dose of mango leaf extract, standardised to contain >60% mangiferin (Zynamite®), on cognitive function and mood. This study adopted a double-blind, placebo-controlled cross-over design in which 70 healthy young adults (18 to 45 years) received 300 mg mango leaf extract and a matched placebo, on separate occasions, separated by at least 7 days. On each occasion, cognitive/mood assessments were undertaken pre-dose and at 30 min, 3 h and 5 h post-dose using the Computerised Mental Performance Assessment System (COMPASS) assessment battery and the Profile of Mood States (POMS). The results showed that a single dose of 300 mg mango leaf extract significantly improved performance accuracy across the tasks in the battery, with domain-specific effects seen in terms of enhanced performance on an ‘Accuracy of Attention’ factor and an ‘Episodic Memory’ factor. Performance was also improved across all three tasks (Rapid Visual Information Processing, Serial 3s and Serial 7s subtraction tasks) that make up the Cognitive Demand Battery sub-section of the assessment. All of these cognitive benefits were seen across the post-dose assessments (30 min, 3 h, 5 h). There were no interpretable treatment related effects on mood. These results provide the first demonstration of cognition enhancement following consumption of mango leaf extract and add to previous research showing that polyphenols and polyphenol rich extracts can improve brain function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

et al. 2020

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“…The drug's sequential dosing compromises heart activity, eventually leading to cardiac failure and death. Ultrastructural alterations in DOX-treated cardiac tissues, such as the development of vacuoles, sarcomere disruption and myocyte necrosis, corroborate this theory (Prabhu et al, 2006;Li et al, 2020aLi et al, , 2020b.…”

Section: Mangiferin and Cardio Protectionmentioning

confidence: 71%

“…Mangiferin also serves as a memory enhancer and aids in the learning process. Mangiferin's ability to reduce neuroinflammation and brain oxidative damage caused by stress is equally impressive (Li et al, 2020a(Li et al, , 2020b.…”

Section: Mangiferin and Brainmentioning

confidence: 99%

Perspectives on the potential of Mangiferin as a nutraceutical: a review

Jamwal

Saini

Tomar

et al. 2022

NFS

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Purpose The aim of this study is to provide a review of the research studies that took place in the previous years regarding Mangiferin and its potential use in the treatment of various disorders such as diabetes, cardiovascular diseases, cancer and human immunodeficiency virus. Design/methodology/Approach Mangiferin can be easily extracted from the plant at a very low cost to treat some common as well as deadly diseases, which will be a miracle in herbal treatment. In support of this, the recent related articles were considered to understand the bioactive compound “Mangiferin” to treat lifestyle diseases. Various review articles and research papers were collected from international and national journals, and internet sources were also being used to compile the current manuscript. Findings Mangiferin has been shown to have the potential to mitigate many life style diseases such as diabetes, obesity, hypertension, fatty liver, atherosclerosis, dyslipidemia and diabetes-related end-organ complications such as retinopathy, neuropathy and nephropathy. Originality/value In this comprehensive review, this study evaluates Mangiferin and its lifestyle disease-modifying properties for nutraceuticals purposes.

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“…Furthermore, TFs and miRNAs interact with each other through complex molecular regulatory mechanisms ( Zhang et al, 2015 ), which play a crucial part in the pathogenesis of VaD ( Saggu et al, 2016 ; Han et al, 2020 ; Yang and Zhang, 2021 ). For example, the nuclear factor erythroid 2-related factor 2 ( Nrf2 ), considered as the essential transcription factor for antioxidant responses, controls the transcription of a series of anti-oxidative and anti-inflammatory genes ( Li et al, 2020a ; Saha et al, 2020 ); as the functional target of miR-153 and miR-144, Nrf2 ameliorates oxidative stress and inhibits the apoptotic signaling pathways ( Chu et al, 2019 ; Zhu et al, 2019 ). Forkhead box P2 ( Foxp2 ) is another transcription factor involved in early VaD and improves cognitive impairment in rats with VaD through the upregulation of synaptic proteins through the miR-134-5p/ Foxp2 / Syn1 axis ( Liu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia

et al. 2022

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Vascular dementia (VaD) is the second most common form of dementia with uncertain mechanisms and no effective treatments. microRNAs (miRNAs) and transcription factors (TFs) are considered regulatory factors of genes involved in many diseases. Therefore, this work investigated the aberrantly expressed miRNAs, TFs, corresponding target genes, and their co-regulatory networks in the cortex of rats with bilateral common carotid artery occlusion (2VO) to uncover the potential mechanism and biomarkers of VaD. Differentially expressed genes (DEGs), miRNAs (DEMs), and TFs (DETFs) were identified using RNA sequencing, and their interaction networks were constructed using Cytoscape. The results showed that rats with 2VO had declined cognitive abilities and neuronal loss in the cortex than sham rats. DEGs, DEMs, and DETFs were discriminated between rats with 2VO and sham rats in the cortex, as shown by the 13 aberrantly expressed miRNAs, 805 mRNAs, and 63 TFs. The miRNA-TF-target gene network was constructed, showing 523 nodes and 7237 edges. Five miRNAs (miR-5132-5p, miR-764-3p, miR-223-3p, miR-145-5p, and miR-122-5p), ten TFs (Mxi1, Nfatc4, Rxrg, Zfp523, Foxj2, Nkx6-1, Klf4, Klf5, Csrnp1, and Prdm6), and seven target genes (Serpine1, Nedd4l, Pxn, Col1a1, Plec, Trip12, and Tpm1) were chosen as the significant nodes to construct feed-forward loops (FFLs). Gene Ontology and pathway enrichment analysis revealed that these miRNA and TF-associated genes are mostly involved in the PI3K/Akt, neuroactive ligand–receptor interaction, calcium signaling, and Wnt signaling pathways, along with central locations around the cell membrane. They exert functions such as growth factor binding, integrin binding, and extracellular matrix structural constituent, with representative biological processes like vasculature development, cell–substrate adhesion, cellular response to growth factor stimulus, and synaptic transmission. Furthermore, the expression of three miRNAs (miR-145-5p, miR-122-5p, and miR-5132-5p), six TFs (Csrnp1, Klf4, Nfatc4, Rxrg, Foxj2, and Klf5), and five mRNAs (Serpine1, Plec, Nedd4l, Trip12, and Tpm1) were significantly changed in rats with VaD, in line with the outcome of RNA sequencing. In the potential FFL, miR-145-5p directly bound Csrnp1 and decreased its mRNA expression. These results might help the understanding of the underlying regulatory mechanisms of miRNA-TF-genes, providing potential therapeutic targets in VaD.

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Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway

Cited by 18 publications

References 76 publications

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

Perspectives on the potential of Mangiferin as a nutraceutical: a review

RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia

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