Mangiferin: Analgesic properties in neuropathic pain, molecular docking and meta-analysis

Chang, Botao; Jiang, Huizhong; Wei, Yi-jing; Gong, Qiu-ju; Yu, Dan; Dong, Zhiyu; Luo, Jun; Gao, Ying; Yao, Qi

doi:10.1016/j.phyplu.2021.100170

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Mounting Pharmacological evidence has indicated numerous bioactivity and therapeutic actions of mangiferin. More recently, scientists have shown different biological potentials of mangiferin compounds including antioxidant 23 , antimicrobial 24 , antifungal 25 , anti-diabetic 26 , analgesia 27 , anti-inflammatory 28 , anti-apoptotic actions 29 , and cardioprotective 30 .…”

Section: Introductionmentioning

confidence: 99%

Mangiferin (mango) attenuates AOM-induced colorectal cancer in rat’s colon by augmentation of apoptotic proteins and antioxidant mechanisms

Abdul-Aziz Ahmed,

Jabbar,

Abdulla

et al. 2024

Sci Rep

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Mangiferin (MF) is a natural C-glucosylxantone compound that has many substantial curative potentials against numerous illnesses including cancers. The present study's goal is to appraise the chemo preventive possessions of MF on azoxymethane (AOM)-mediated colonic aberrant crypt foci (ACF) in rats. Rats clustered into 5 groups, negative control (A), inoculated subcutaneously with normal saline twice and nourished on 0.5% CMC; groups B-E injected twice with 15 mg/kg azoxymethane followed by ingestion of 0.5% CMC (B, cancer control); intraperitoneal inoculation of 35 mg/kg 5-fluorouracil (C, reference rats) or nourished on 30 mg/kg (D) and 60 mg/kg (E) of MF. Results of gross morphology of colorectal specimens showed significantly lower total colonic ACF incidence in MF-treated rats than that of cancer controls. The colon tissue examination of cancer control rats showed increased ACF availability with bizarrely elongated nuclei, stratified cells, and higher depletion of the submucosal glands compared to MF-treated rats. Mangiferin treatment caused increased regulation of pro-apoptotic (increased Bax) proteins and reduced the β-catenin) proteins expression. Moreover, rats fed on MF had significantly higher glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and lower malondialdehyde (MDA) concentrations in their colonic tissue homogenates. Mangiferin supplementation significantly down-shifted pro-inflammatory cytokines (transforming growth factor-α and interleukine-6) and up-shifted anti-inflammatory cytokines (interleukine-10) based on serum analysis. The chemo-protective mechanistic of MF against AOM-induced ACF, shown by lower ACF values and colon tissue penetration, could be correlated with its positive modulation of apoptotic cascade, antioxidant enzymes, and inflammatory cytokines originating from AOM oxidative stress insults.

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Section: Introductionmentioning

confidence: 99%

Mangiferin (mango) attenuates AOM-induced colorectal cancer in rat’s colon by augmentation of apoptotic proteins and antioxidant mechanisms

Abdul-Aziz Ahmed,

Jabbar,

Abdulla

et al. 2024

Sci Rep

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Chemistry and biological activities of naturally occurring C-glycosylxanthones

Happi,

Ntabo,

Sikam

et al. 2023

South African Journal of Botany

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Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

Kaur,

Muthuraman

2023

RJPT

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Gallic acid (GA) is one of the natural flavonoids and it is known to protect the neuronal system from various endogenous neurodegenerative processes. The present study is focused on evaluating the role of GA in chronic construction injury (CCI) of sciatic nerve-induced neuropathic pain. The test compound i.e., gallic acid (20 and 40mg/kg), and reference compound i.e., pregabalin (PrG: 5mg/kg) were administered intravenously for 10 consecutive days. The sciatic nerve injury-induced neuralgic sensations were assessed with multiple test methods like acetone drop, pinprick, plantar, tail-flick, and tail pinch tests at different time points i.e., 0, 4th, 8th, 12th, and 16th days. The biochemical level changes i.e., thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide anion, calcium, myeloperoxidase (MPO), and tumor necrosis factor–α (TNF-α) were estimated in sciatic nerve samples. The administration of GA and PreG was shown a significant ameliorative effect against the CCI-induced pain response in a dose-dependent manner. Moreover, it also attenuated the tissue biochemical changes. The observed effects of GA were similar to reference drug PreG treated groups. Hence, GA has neuroprotective and pain relief effects against the CCI-induced neuralgia. It may be due to its natural free radical scavenging; regulation of inflammatory proteins; expression of antioxidant proteins, reduction of intracellular free calcium, and prevention of neuroinflammatory actions.

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Mangiferin: Analgesic properties in neuropathic pain, molecular docking and meta-analysis

Cited by 3 publications

References 41 publications

Mangiferin (mango) attenuates AOM-induced colorectal cancer in rat’s colon by augmentation of apoptotic proteins and antioxidant mechanisms

Mangiferin (mango) attenuates AOM-induced colorectal cancer in rat’s colon by augmentation of apoptotic proteins and antioxidant mechanisms

Chemistry and biological activities of naturally occurring C-glycosylxanthones

Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

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