Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection

Rechenchoski, Daniele Zendrini; Agostinho, Karoline Fontana; Faccin-Galhardi, Lígia Carla; Lonni, Audrey Alesandra Stinghen Garcia; Silva, João Vinícius Honório da; Andrade, Fábio Goulart de; Cunha, Arcelina Pacheco; Ricardo, Nágila Maria Pontes Silva; Nozawa, Carlos; Linhares, Rosa Elisa Carvalho

doi:10.1016/j.bmc.2020.115304

Cited by 18 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The formulations were added during different phases of infection to determine the time and mode of action. A preliminary study allowed us to select 50 ug/mL MG as the concentration, being efficacious and not toxic to Vero cells up to 500 ug/mL, as described by Rechenchoski et al [ 12 ]. The percent reduction was calculated relative to the amount of viral control in the absence of formulations.…”

Section: Resultsmentioning

confidence: 99%

“…In this respect many plant extracts widely used in medicine possess interesting therapeutic potential, such as antimicrobial and antiviral activities. For instance, balm mint extracts, Brazilian propolis extracts, rosemary, lemon balm oil, quercetin, and mangiferin (MG) demonstrated and inhibitory activity against HSV-1 [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…MG is a natural glucosyl xanthone derived from mango or papaya, characterized by an interesting pharmacological potential, exerting antioxidant, antiapoptotic, antiinflammatory, anticarcinogenic, and antidiabetic properties as well as antiviral action against herpes simplex virus and polio virus [12][13][14][15]. A recent investigation has highlighted the MG virucidal effect against HSV-1, suggesting its topical use to inactive virus replication and to minimize the selection of resistance, thus counteracting acyclovir-resistant Pharmaceutics 2021, 13, 1323 2 of 18 infections [12]. Notwithstanding its therapeutic potential, MG is not soluble in water and has low bioavailability, requiring the use of specialized delivery systems able to dissolve the drug while maintaining its stability against oxidative degradation [16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

et al. 2021

View full text Add to dashboard Cite

Infections due to HSV-1 affect many people all over the world. To counteract this pathology, usually characterized by perioral sores or by less frequent serious symptoms including keratitis, synthetic antiviral drugs are employed, such as acyclovir, often resulting in resistant viral strains under long-term use. Many plant-derived compounds, such as mangiferin and quercetin, have demonstrated antiviral potentials. In this study, smart semisolid forms based on phosphatidylcholine and Pluronic were investigated as delivery systems to administer mangiferin on skin and mucosae affected by HSV-1 infection. Particularly, lecithin organogels, Pluronic gel, and Pluronic lecithin organogels were formulated and characterized. After the selection of gel compositions, physical aspects, such as rheological behavior, spreadability, leakage, and adhesion were evaluated, suggesting a scarce suitability of the lecithin organogel for topical administration. Mangiferin was efficiently included in all type of gels. An in vitro study based on the Franz cell enabled us to find evidence of the gel capability to control drug diffusion, especially in the case of Pluronic organogel, while an in vivo study conducted on human volunteers demonstrated the safeness of all of the gels after cutaneous administration. Furthermore, a plaque reduction assay demonstrated the virucidal effect of mangiferin loaded in a Pluronic gel and a Pluronic lecithin organogel against the HSV-1 KOS strain.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In A. asphodeloides , an abundant of bioactive flavonoid C -glycosides, such as mangiferin and neomangiferin, have been isolated from its rhizomes [ 9 ]. Among these, mangiferin is one of the main bioactive ingredients, which has been reported to exhibit various pharmacological activities, including anti-inflammatory [ 10 ], antivirus [ 11 ], anti-cardiac vascular diseases [ 12 ], and antitumor activities [ 13 ]. Different from common flavonoid glycosides, mangiferin belongs to a canonical xanthone C -glycoside, which is produced from the cyclization reaction of a benzophenone C -glycoside in plant secondary metabolism and rare in monocotyledons [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the catalytic function and active sites of a novel C-glycosyltransferase from Anemarrhena asphodeloides

Huang

She

Yue

et al. 2022

Synthetic and Systems Biotechnology

View full text Add to dashboard Cite

“…Indeed, due to their antioxidant properties, polyphenols can be employed in the prevention or treatment of diseases correlated to oxidative stress [14]. For instance, quercetin (QT) and mangiferin (MG), as well as being powerful antioxidants and anti-inflammatories, have shown antiviral activity, such as in the treatment of HSV-1, being able to inhibit its replication [15][16][17][18]. Despite their therapeutic potential, both QT and MG are characterized by poor water solubility, limited skin permeation capacity and ease of oxidative degradation [19,20].…”

Section: Introductionmentioning

confidence: 99%

Natural Polyphenol-Containing Gels against HSV-1 Infection: A Comparative Study

et al. 2022

View full text Add to dashboard Cite

Herpes simplex virus type 1 infection commonly affects many people, causing perioral sores, as well as severe complications including encephalitis in immunocompromised patients. The main pharmacological approach involves synthetic antiviral drugs, among which acyclovir is the golden standard, often leading to resistant virus strains under long-term use. An alternative approach based on antiviral plant-derived compounds, such as quercetin and mangiferin, demonstrated an antiviral potential. In the present study, semisolid forms for cutaneous application of quercetin and mangiferin were designed and evaluated to treat HSV-1 infection. Phosphatidylcholine- and poloxamer-based gels were produced and characterized. Gel physical–chemical aspects were evaluated by rheological measurements and X-ray diffraction, evidencing the different thermoresponsive behaviors and supramolecular organizations of semisolid forms. Quercetin and mangiferin diffusion kinetics were compared in vitro by a Franz cell system, demonstrating the different gel efficacies to restrain the polyphenol diffusion. The capability of gels to control polyphenol antioxidant potential and stability was evaluated, indicating a higher stability and antioxidant activity in the case of quercetin loaded in poloxamer-based gel. Furthermore, a plaque reduction assay, conducted to compare the virucidal effect of quercetin and mangiferin loaded in gels against the HSV-1 KOS strain, demonstrated the suitability of poloxamer-based gel to prolong the polyphenol activity.

show abstract

Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection

Cited by 18 publications

References 21 publications

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

Exploring the catalytic function and active sites of a novel C-glycosyltransferase from Anemarrhena asphodeloides

Natural Polyphenol-Containing Gels against HSV-1 Infection: A Comparative Study

Contact Info

Product

Resources

About