Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ receptors and others markers associated with obesity

Brito, Larissa Froede; Gontijo, Douglas Costa; Toledo, Renata Celi Lopes; Barcelos, Rafael Mazioli; Oliveira, Alaı́de Braga de; Brandão, Geraldo Célio; Sousa, Lirlândia P.; Ribeiro, Sônia Machado Rocha; Leite, João Paulo Viana; Fietto, Luciano Gomes; Queiroz, José Humberto de

doi:10.1016/j.jff.2019.03.003

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Furthermore, MI leaf aqueous extract was found to increase high-density lipoprotein levels (23). The ethanol (95%) extract of MI leaves and mangiferin modulated the endocannabinoid (CB) system and peroxisome proliferator-activated receptor-γ (PPARγ) mRNA expression in cafeteria diet-fed rats, suggesting a possible role for MI in controlling obesity and metabolic syndrome (24). The endocannabinoid system has been reported to contribute to weight gain and glucose intolerance, while PPARγ is one the key regulators of adipose cell development and differentiation (24).…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

et al. 2022

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Among the different types of mango species, Mangifera indica (MI) and Mangifera zeylanica (MZ) are well known for their therapeutic potential. MI is a pharmacologically and phytochemically diverse plant. Extracts prepared from different parts (bark, leaves, roots, seeds, flowers and fruits) of MI and major mango phytochemicals have been reported to exert a range of pharmacological effects. MZ is a plant endemic to Sri Lanka. The bark of MZ has been used in the Sri Lankan traditional medicine for the treatment of various ailments and conditions, including cancer. Recently, substantial efforts have been made to provide a scientific validation for its traditional use in the treatment of cancer. The present review article describes the pharmacological activities, including anti-inflammatory, antioxidant, anticancer, anti-microbial, anti-diabetic and anti-obesity properties of MI. Furthermore, the anticancer potential of MZ bark extracts and information on compounds isolated from MZ and their bio-activities are also described. The effects of major Mangifera compounds on epigenetic modifications have been widely studied. Therefore, the ability of Mangifera compounds to function as epigenetic drugs in the context of cancer drug discovery has become a promising area of investigation. However, an assessment of the clinical efficacy, and potential adverse and toxic effects of mango extracts is essential prior to their use in clinical practice.

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Section: Antioxidant Propertiesmentioning

confidence: 99%

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

et al. 2022

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“…Although strategies targeting CB 1 R/PPARα have been explored in further depth for the treatment of obesity, the concomitant modulation of CB 1 R and PPARγ may also be useful for the control of metabolic syndrome and related disorders. A recent study demonstrated that these two targets are involved in the antiobesity and antiadipogenic effects of leaves extracts from Mangifera indica (EMI) [77]. Treatment with EMI led to a reduction of food intake and adipose tissue in a rat model of cafeteria diet-induced obesity.…”

Section: Cb 1 R-pparγmentioning

confidence: 99%

“…Curiously, the major bioactive component of EMI, the xanthone glycoside mangiferin (Figure 1), produced proadipogenic effects in the same rat model. The presence of other phenolic compounds identified in the extracts may enable the beneficial effects produced by EMI when compared to isolated mangiferin [77]. Studies to explore the direct modulation of CB 1 R and PPARγ with the extracts and with the isolated compounds remain to be done.…”

Section: Cb 1 R-pparγmentioning

confidence: 99%

Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System

Lago-Fernandez¹,

Zarzo-Arias²,

Jagerovic³

et al. 2021

IJMS

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Cannabinoids have shown to exert their therapeutic actions through a variety of targets. These include not only the canonical cannabinoid receptors CB1R and CB2R but also related orphan G protein-coupled receptors (GPCRs), ligand-gated ion channels, transient receptor potential (TRP) channels, metabolic enzymes, and nuclear receptors. In this review, we aim to summarize reported compounds exhibiting their therapeutic effects upon the modulation of CB1R and/or CB2R and the nuclear peroxisome proliferator-activated receptors (PPARs). Concomitant actions at CBRs and PPARα or PPARγ subtypes have shown to mediate antiobesity, analgesic, antitumoral, or neuroprotective properties of a variety of phytogenic, endogenous, and synthetic cannabinoids. The relevance of this multitargeting mechanism of action has been analyzed in the context of diverse pathologies. Synergistic effects triggered by combinatorial treatment with ligands that modulate the aforementioned targets have also been considered. This literature overview provides structural and pharmacological insights for the further development of dual cannabinoids for specific disorders.

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“…The principal compounds extracted from different mango parts (pulp, peel, seed, leaves, and bark) have been done by SLE, presenting a broad biological activity as can be observed in Table 2. Mango bark presents antimicrobial activity 39,56,57 against Escherichia coli, Salmonella enteritidis, Shigella, Bacillus cereus, Staphylococcus aureus, and Enterococcus faecalis related to its volatile compounds; 26,58 and the leaves present antioxidant, 8,42,59,60 anti-inflammatory, 8,40,61 and antiproliferative activity, 60 due to the presence of phenolic compounds, mainly gallic acid and mangiferin. The peel and pulp extract present antioxidant activity, 23,29,42,43,60,62 and the seed kernel antiproliferative activity.…”

Section: Conventional Extraction Techniquesmentioning

confidence: 99%

Bioactive compounds of mango (Mangifera indica): a review of extraction technologies and chemical constituents

2021

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Mango (Mangifera indica) has been recognized as a rich source of bioactive compounds with potential pharmaceutical and nutraceutical applications and has attracted increasing interest from research. Phytochemistry studies have demonstrated that phenolic compounds are one of the most important biologically active components of M. indica extracts. Ultrasound-and microwave-assisted extractions and supercritical fluids have been employed to obtain bioactive molecules, such as phenolic acids, terpenoids, carotenoids, and fatty acids. These phytochemicals exhibit antioxidant, antimicrobial, anti-inflammatory, and anticancer activity, and depending on the source (bark, leaves, seeds, flowers, or peel) and extraction method there will be differences in the structure and bioactivity. This review examines the bioactive compounds, extraction techniques, and biological function of different parts of M. indica of great importance as nutraceuticals and functional compounds with potential application as therapeutic agents and functional foods.

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Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ receptors and others markers associated with obesity

Cited by 9 publications

References 43 publications

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

Mangifera indica and Mangifera zeylanica: Perspectives on medicinal properties, therapeutic applications and potential uses as anticancer epigenetic drugs (Review)

Relevance of Peroxisome Proliferator Activated Receptors in Multitarget Paradigm Associated with the Endocannabinoid System

Bioactive compounds of mango (Mangifera indica): a review of extraction technologies and chemical constituents

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