Mangifera indica L. Leaves as a Potential Food Source of Phenolic Compounds with Biological Activity

Abstract

It is well recognized that functional foods rich in antioxidants and antiinflammation agents including polyphenols, probiotics/prebiotics, and bioactive compounds have been found to have positive effects on the aging process. In particular, fruits play an important role in regular diet, promoting good health and longevity. In this study, we investigated on biological properties of extract obtained from Mangifera indica L. leaves in preclinical in vitro models. Specifically, the profile and content of bioactive compounds, the antimicrobial potential toward food spoilage and pathogenic bacterial species, and the eventually protective effect in inflammation were examined. Our findings revealed that MLE was rich in polyphenols, showing a content exclusively in the subclass of benzophenone/xanthone metabolites, and these phytochemical compounds demonstrated the highest antioxidant capacity and greatest in vitro antibacterial activity toward different bacterial species such as Bacillus cereus, B. subtilis, Pseudomonas fluorescens, Staphylococcus aureus, and St. haemolyticus. Furthermore, our data showed an in vitro anti-inflammatory, antioxidant, and antifibrotic activity.

Nanostructured Lipid Carriers Aimed to the Ocular Delivery of Mangiferin: In Vitro Evidence

“…With the only exception of the highest concentration for both treatments (>80 μL/mL), no toxicity compared to the control was observed for all formulations ( Figure 6 ). The data confirm that nanostructured lipid carriers at the same concentrations as those of mangiferin used in previous studies show no cytotoxicity effects alone or loaded with MGN [ 9 , 29 , 38 ].…”

“…The antioxidant properties of polyphenols or natural substances are often related to a decrease in ROS formation in the tested cells. The presence of ROS reflects the induction of oxidative stress and is responsible for the onset of cardiovascular, metabolic and neoplastic diseases, as well as macular degeneration [ 9 , 28 , 39 , 40 , 41 ]. To investigate a possible maintenance of the protective role of MGN in oxidative stress, we treated ARPE-19 in the presence and absence of 0.5 mM H 2 O 2 .…”

“…Mangiferin (MGN, 1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2-yl]-9 H -xanten-9-one) is a natural compound, mainly isolated in various parts of Mangifera indica L., including leaves, stem barks and fruits [ 7 ], and it possesses interesting anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic and antioxidant health-related properties [ 8 , 9 ]. The latter is due to the hydroxyl groups present in its chemical structure ( Figure 1 ) that are capable of preventing the production of hydroxyl radicals thanks to their iron chelating ability in Fenton-type reactions [ 10 ].…”

Cookies Fortified with Lonicera japonica Thunb. Extracts: Impact on Phenolic Acid Content, Antioxidant Activity and Physical Properties

“…The DPPH free radical scavenging activity of cookies was determined according to the method reported by Sferrazzo et al [ 26 ] with some modifications. DPPH solution (900 μL) was added to 100 μL cookie extracts and the mixture reacted for 10 min in the dark.…”

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

“…Mango fruit is appreciated for its nutritive and nutraceutical properties [ 32 , 33 ]. It has been shown that different parts of the plant and of the fruit exert anti-inflammatory, anti-oxidant and anti-tumor effects in in vitro as well as in vivo models because of the presence of a wide range of polyphenols [ 34 , 35 , 36 ].…”