Manganese Supplementation Reduces the Blood Cholesterol Levels in Ca-Deficient Ovariectomized Rats

Bae, Yun‐Jung; Choi, Mi‐Kyeong; Kim, Mi‐Hyun

doi:10.1007/s12011-010-8714-1

Cited by 34 publications

(23 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The oral administration of OHS significantly (p<0.05) suppressed serum GOT and GPT elevation when compared to the OVX group. The serum GPT and GOT levels often increase in response to liver injury, fatty liver and hepatitis (49). In the present study, decreases in the levels of GPT and GOT were observed in the OHS groups, suggesting that OHS confers protection on liver tissues against damage or disease.…”

Section: Effects Of Ohs On Hepatic Enzymes In Serumsupporting

confidence: 58%

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Hahm¹,

Park²,

Son³

2011

JFN

View full text Add to dashboard Cite

Opuntia humifusa contains high levels of antioxidants including vitamin C, flavonoids and polyphenols, which may provide beneficial effects such as hypolipidemic activity and the reduction of atherosclerosis in postmenopausal women. This study was conducted to determine if the intake of O. humifusa seeds powder (OHS) regulates lipid concentrations, glutamate-oxaloacetate transaminase (GOT), and glutamate-pyruvate transaminase (GPT) in the serum of ovariectomized rats. Sprague-Dawley female rats were randomly assigned to either a sham-operated group (Sham) or one of the following four ovariectomy (OVX) subgroups: OVX with vehicle (OVX), OVX with 100, 200, and 500 mg/kg/day OHS (OHS100, OHS200, OHS500). Daily oral administration of OHS was initiated one week after ovariectomy and continued for seven weeks. Upon completion of treatments, organs were weighed and GOT, GPT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels were determined enzymatically. No significant differences in feed intake and organ index were observed among the groups. Significant decreases in GPT, TC and LDL-C (p<0.05) were observed in all of the OHS groups (OHS100, 200 and 500), while no significant changes in HDL-C were observed. In addition, the OHS200 and OHS500 treatment groups exhibited a lower level of serum GOT compared to the OVX group. These results indicate that supplementation with O. humifusa seeds could induce favorable changes in serum lipoprotein and lipid profiles, which frequently worsen with inadequate estrogen availability.

show abstract

Section: Effects Of Ohs On Hepatic Enzymes In Serumsupporting

confidence: 58%

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Hahm¹,

Park²,

Son³

2011

JFN

View full text Add to dashboard Cite

show abstract

“…Group B was supplemented with a 16 mg/kg of body weight dose of Mn 2ϩ . Previous studies have used 0.001% Mn 2ϩ in the diet as an adequate amount and 0.01% Mn 2ϩ as supplementation (19,20). Various studies have reported daily food consumption for ZDF rats to range between 35 and 50 g per day (21,22).…”

Section: Methodsmentioning

confidence: 99%

Manganese Supplementation Reduces High Glucose-induced Monocyte Adhesion to Endothelial Cells and Endothelial Dysfunction in Zucker Diabetic Fatty Rats

Burlet

Jain

2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background:Mn 2ϩ levels are lower in blood of diabetic and atherosclerosis patients. Results: Mn 2ϩ supplementation reduces monocyte adhesion in endothelial cells by down-regulating ROS, ICAM-1 expression, and MCP-1 secretion, and lowers blood levels of ICAM-1 and cholesterol in ZDF rats. Conclusion:Mn 2ϩ supplementation is beneficial in lowering markers of endothelial dysfunction. Significance: Mn 2ϩ supplementation can potentially prevent or delay progression of atherosclerosis.Endothelial dysfunction is a hallmark of increased vascular inflammation, dyslipidemia, and the development of atherosclerosis in diabetes. Previous studies have reported lower levels of Mn 2؉ in the plasma and lymphocytes of diabetic patients and in the heart and aortic tissue of patients with atherosclerosis. This study examines the hypothesis that Mn 2؉ supplementation can reduce the markers/risk factors of endothelial dysfunction in type 2 diabetes. Human umbilical vein endothelial cells (HUVECs) were cultured with or without Mn 2؉ supplementation and then exposed to high glucose (HG, 25 mM) to mimic diabetic conditions. Mn 2؉ supplementation caused a reduction in monocyte adhesion to HUVECs treated with HG or MCP-1. Mn 2؉ also inhibited ROS levels, MCP-1 secretion, and ICAM-1 up-regulation in HUVECs treated with HG. Silencing studies using siRNA against MnSOD showed that similar results were observed in MnSOD knockdown HUVECs following Mn 2؉ supplementation, suggesting that the effect of manganese on monocyte adhesion to endothelial cells is mediated by ROS and ICAM-1, but not MnSOD. To validate the relevance of our findings in vivo, Zucker diabetic fatty rats were gavaged daily with water (placebo) or MnCl 2 (16 mg/kg of body weight) for 7 weeks. When compared with placebo, Mn 2؉ -supplemented rats showed lower blood levels of ICAM-1 (17%, p < 0.04), cholesterol (25%, p < 0.05), and MCP-1 (28%, p ‫؍‬ 0.25). These in vitro and in vivo studies demonstrate that Mn 2؉ supplementation can down-regulate ICAM-1 expression and ROS independently of MnSOD, leading to a decrease in monocyte adhesion to endothelial cells, and therefore can lower the risk of endothelial dysfunction in diabetes.Manganese is an essential micronutrient that serves as a cofactor for many enzyme systems. Metalloenzymes, or manganese-containing enzymes, such as arginase, pyruvate carboxylase, and manganese superoxide dismutase (MnSOD), 2 require Mn 2ϩ to function. MnSOD is the major mitochondrial antioxidant and is responsible for protecting the cell from reactive oxygen species (ROS) by scavenging mitochondrial superoxide (1). MnSOD acts by catalyzing the conversion of superoxide radicals (such as O 2 ) to hydrogen peroxide, which is further metabolized to water by other antioxidant enzymes such as catalase and glutathione peroxidase (2). At low concentrations, Mn 2ϩ ions have been shown to have antioxidant properties with the ability to scavenge superoxide and hydroxyl radicals (3). Several studies have reported that changes in dietary Mn 2ϩ induced changes in MnS...

show abstract

“…Manganese helps the body form connective tissue, bones, blood clotting factors, and sex hormones (Santamaria and Sulsky, 2010). It also plays a role in lipid and carbohydrate metabolism, calcium absorption, and blood glucose regulation (Kehl-Fie and Skaar, 2010;Bae et al, 2011). Manganese is also necessary for normal brain and nerve function.…”

Section: Nutritional Value Of Beefmentioning

confidence: 99%

Genetic parameters for concentrations of minerals in longissimus muscle and their associations with palatability traits in Angus cattle1

Mateescu

Garmyn

Tait

et al. 2013

Journal of Animal Science

View full text Add to dashboard Cite

The objective of this study was to estimate genetic parameters for concentrations of minerals in LM and to evaluate their associations with beef palatability traits. Samples of LM from 2,285 Angus cattle were obtained and fabricated into steaks for analysis of mineral concentrations and for trained sensory panel assessments. Nine minerals, including calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sodium, and zinc, were quantified. Restricted maximum likelihood procedures were used to obtain estimates of variance and covariance components under a multiple-trait animal model. Estimates of heritability for mineral concentrations in LM varied from 0.01 to 0.54. Iron and sodium were highly and moderately heritable, respectively, whereas the other minerals were lowly heritable except for calcium, copper, and manganese, which exhibited no genetic variation. Strong positive genetic correlations existed between iron and zinc (0. ABSTRACT: The objective of this study was to estimate genetic parameters for concentrations of minerals in LM and to evaluate their associations with beef palatability traits. Samples of LM from 2,285 Angus cattle were obtained and fabricated into steaks for analysis of mineral concentrations and for trained sensory panel assessments. Nine minerals, including calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sodium, and zinc, were quantifi ed. Restricted maximum likelihood procedures were used to obtain estimates of variance and covariance components under a multiple-trait animal model. Estimates of heritability for mineral concentrations in LM varied from 0.01 to 0.54. Iron and sodium were highly and moderately heritable, respectively, whereas the other minerals were lowly heritable except for calcium, copper, and manganese, which exhibited no genetic variation. Strong positive genetic correlations existed between iron and zinc (0.49, P < 0.05), between magnesium and phosphorus (0.88, P < 0.05), between magnesium and sodium (0.68, P < 0.05), and between phosphorus and potassium (0.69, P < 0.05). Overall tenderness assessed by trained sensory panelists was positively associated with manganese, potassium, and sodium and negatively associated with phosphorus and zinc concentrations (P < 0.05). Juiciness assessed by trained sensory panelists was negatively associated with magnesium and positively associated with manganese and sodium concentrations (P < 0.05). Livery or metallic fl avor was not associated with any of the minerals (P > 0.05). Beefy fl avor was positively associated with calcium, iron, and zinc and negatively associated with sodium concentration, whereas a painty or fi shy fl avor was positively associated with sodium and negatively associated with calcium and potassium concentrations (P < 0.05). Beef is a major contributor of iron and zinc in the human diet, and these results demonstrate suffi cient genetic variation for these traits to be improved through marker-assisted selection programs without compromising beef palatability. 05). Li...

show abstract

Manganese Supplementation Reduces the Blood Cholesterol Levels in Ca-Deficient Ovariectomized Rats

Cited by 34 publications

References 20 publications

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Effects of Opuntia humifusa Seed Powder on Serum Lipid Profile in Ovariectomized Rats

Manganese Supplementation Reduces High Glucose-induced Monocyte Adhesion to Endothelial Cells and Endothelial Dysfunction in Zucker Diabetic Fatty Rats

Genetic parameters for concentrations of minerals in longissimus muscle and their associations with palatability traits in Angus cattle1

Contact Info

Product

Resources

About