Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer

Miar, Ana; Hevia, David; Muñoz-Cimadevilla, Henar; Astudillo, Aurora; Velasco, Julio; Sainz, Rosa M.; Mayo, Juan C.

doi:10.1016/j.freeradbiomed.2015.04.001

Cited by 103 publications

(95 citation statements)

References 59 publications

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“…In a previous study from our group (25), protein carbonylation levels, as measured by malondialdehyde (MDA)-protein adducts, were also increased in the normal epithelium of patients with LC, especially in patients with underlying COPD, whose levels were significantly greater than in those without this disease. These findings were consistent with those reported in previous investigations, in which a rise in different redox markers was demonstrated in lung tissues or blood of patients with LC (19,20,25,37,101).…”

Section: Redox Balancesupporting

confidence: 93%

“…Furthermore, in LC patients with COPD, the heaviest smokers were those showing the decrease in catalase levels in the tumor lesions compared to the nontumor lungs (26). These findings are consistent with other studies in which catalase deficiency was shown to contribute to mammary tumorigenesis in rodents (119) and cancer in patients (37). Collectively, it would be possible to conclude that catalase depletion seems to be involved in cancer development, especially in LC patients with underlying COPD, especially in those who were heavy smokers.…”

Section: Reactive Oxygen Speciessupporting

confidence: 91%

“…Furthermore, SOD2 was also shown to favor cell migration and invasiveness of tumors in other investigations (117,118). More recently, mRNA and protein levels of SOD2 were also significantly increased in lung tumors and other cancer types in patients (37). The authors concluded that SOD2 may even be considered as a biomarker for cancer progression, from tumor growth to metastasis.…”

Section: Redox Balancementioning

confidence: 87%

“…For instance, oxidative and nitrosative stress as a result of reactive oxygen and nitrogen species (ROS and RNS, respectively) were shown to favor carcinogenesis through the activation of cellular processes that result in neoplastic transformation or the induction of DNA mutations (32). Other investigations have also demonstrated the contribution of oxidative damage, inflammatory events, and tumor microenvironment to lung carcinogenesis in patients and animal models (19,20,(25)(26)(27)(28)(29)(30)(31)(33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

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Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

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Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.

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Section: Redox Balancesupporting

confidence: 93%

Section: Reactive Oxygen Speciessupporting

confidence: 91%

Section: Redox Balancementioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

View full text Add to dashboard Cite

show abstract

“…Interestingly, in mice, a reduction in tumor burden was also demonstrated in response to the inhibition of superoxide dismutase (SOD)1 by the small molecule ATN-2, while it also favored cell death in different NSCLC cell lines (24). Very recently, SOD2 upregulation and catalase downregulation were also shown to act as potential biomarkers of tumor progression in several cancer types in actual patients (25). Taken together, these findings suggest that oxidative damage and antioxidant dysregulation induce and promote carcinogenesis in different experimental models.…”

Section: Study Design and Patientsmentioning

confidence: 99%

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Mateu-Jiménez

Sánchez-Font

Rodríguez-Fuster

et al. 2016

Mol Med

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Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in lung tumors and blood compartments of patients with non-small cell LC (NSCLC) with and without COPD. Redox markers (immunoblotting, ELISA, chemiluminescence, 2D electrophoresis and proteomics) were analyzed in blood samples of 17 control subjects and 80 LC patients (59 LC-COPD and 21 LC) and lung specimens (tumor and nontumor) from those undergoing thoracotomy (35 patients: 23 LC-COPD and 12 LC). As smoking history was more prevalent in LC-COPD patients, these were further analyzed post hoc as heavy and moderate smokers (cutoff, 60 pack-years). Malondialdehyde (MDA)-protein adducts and SOD1 levels were higher in tumor and nontumor samples of LC-COPD than in LC. In tumors compared with nontumors, SOD2 protein content was greater, whereas catalase levels were decreased in both LC and LC-COPD patients. Blood superoxide anion levels, protein carbonylation and nitration were greater in LC and LC-COPD patients than in the controls, and in the latter patients compared with the former. Systemic superoxide anion, protein carbonyls and nitrotyrosine above specific cutoff values best identified underlying COPD among all patients. Smoking did not influence the study results. A differential expression profile of oxidative stress markers exists in blood and, to a lesser extent, in the tumors of LC-COPD patients. These findings suggest that systemic oxidative stress and lung antioxidants (potential biomarkers) may predispose patients with chronic respiratory diseases to a higher risk for LC.

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Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

Rabajdová,

Špaková,

Smolko

et al. 2023

FEBS Open Bio

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Abstract:Endometriosis and endometrial cancer are closely related with oxidative stress. However, the direct relationship between copper and zinc levels and oxidative stress in the extracellular and intracellular space remains unclear. The presented study is focused on determination of serum Zn and Cu levels, glutathione concentration and enzyme activity in three groups: patients diagnosed with endometrial cancer (EC), patients diagnosed with endometriosis (EM) and a healthy control group. Spectrophotometric determination of trace elements revealed that levels of zinc and copper were lower in blood plasma of patients with endometriosis as compared with the other groups; however, there were no significant differences in the Cu/Zn ratio. Furthermore, significantly increased blood serum glutathione levels were detected in both EM and EC groups compared to the control group. While the activity of superoxide dismutase (SOD) was similar across the studied groups, we observed differences in the activity of other enzymes associated with oxidative stress, including glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S‐transferase (GST), between the control group and the EM and EC patients. Additionally, analysis of gene expression based on free circulating mRNA indicated significant differences in the expression of SOD isoenzymes between the patient groups and the control group; expression of GPx isoenzymes was also altered. Our results may have potential application in diagnostics as well as monitoring of endometriosis and endometrial cancer.

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Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer

Cited by 103 publications

References 59 publications

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

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