Manganese superoxide dismutase Ile58Thr, catalase C‐262T and myeloperoxidase G‐463A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease

Abstract

Objective• To evaluate the relationship between manganese superoxide dismutase (MnSOD) Ile58Thr, catalase (CAT) C-262T and myeloperoxidase (MPO) G-463A gene polymorphisms and the susceptibility and clinicopathological characteristics of prostate cancer. Patients and Methods• In all, 155 patients diagnosed with prostate cancer and 195 controls with negative digital rectal examinations and PSA levels of <4 ng/dL were enrolled in this study.• MnSOD, CAT and MPO gene polymorphisms were identified by polymerase chain reaction restriction-fragment length polymorphism methods.

Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results

“…In addition, Karunasinghe et al (2012) found a significant association between the C-262T allele and increased risk to PCa. In accordance with these results, Tefik et al (2013) found that CAT C-262T polymorphism is associated with increased risk to PCa. Interestingly, some studies have reported no association between CAT polymorphism and PCa (Choi et al, 2007;Ding et al, 2012).…”

“…The activity of CAT, which is an essential antioxidant, was found to be significantly diminished in PCa patients. There are conflicting results in the literature regarding the role of the CAT (C-262T) gene polymorphism in PCa (Choi et al, 2007;Battisti et al, 2011;Karunasinghe et al, 2012;Tefik et al, 2013;Geybels et al, 2015;Hu et al, 2015). Geybels et al (2015) suggested that CAT gene polymorphism is associated with stage III/IV prostate cancers.…”

Genetic Polymorphism of C-262T Catalase and Susceptibility to Schizophrenia

“…At present we know that chronic exposure to excess ROS may contribute to brain damage and pathophysiology of schizophrenia [1,2,11,12], CAT involved in detoxification of ROS [5][6][7][8][9][10], and C-262T polymorphism is associated with CAT activity [3,4]. Taken together, these findings sufficiently provide us with a theoretical ration to investigate the association between CAT C-262T polymorphism and susceptibility to schizophrenia.…”

“…Several studies indicated that the polymorphism of C-262T CAT is associated with some multifactorial diseases [5][6][7][8][9][10]. At present we know that chronic exposure to excess ROS may contribute to brain damage and pathophysiology of schizophrenia [1,2,11,12], CAT involved in detoxification of ROS [5][6][7][8][9][10], and C-262T polymorphism is associated with CAT activity [3,4].…”

Analysis of genes polymorphism of catecholamines metabolism and antioxidant system in women with recurrent miscarriage

“…Одним из наиболее важных звеньев АОС является фермент каталаза, ген САТ которой локализован на 11-й хромосоме [14]. В нашем исследовании объектом изучения был выбран наименее описанный полиморфизм Т21А rs 17880664 гена САТ, при котором происходит замена азотисто-го основания тимина на аргинин в позиции 21 ну-клеотида, изученный в контексте предрасположен-ности к развитию некоторых соматических заболе-ваний [15,16]. Установлено, что у пациенток с невы-нашиванием беременности дикий аллель Т в гомози-готном состоянии выявлен в 40,98% (n=125), что до-стоверно не различалось от показателей в группе здоровых женщин -38,74% (n=74).…”