Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas

Fu, Ting‐Ying; Hou, Yu‐Yi; Chu, Sau-Tung; Liu, Ching-Feng; Huang, Chenghui; Chen, Hung-Chih; Hsiao, Michael; Lu, Pei-Jung; Wang, Jyh-Seng; Ger, Luo‐Ping

doi:10.1002/hed.21653

Cited by 38 publications

(32 citation statements)

References 38 publications

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“…For example, the correlation between multiple oxidative stress biomarkers and breast cancer, squamous cell carcinomas, leukemia, and colorectal cancer was found (106,221,390,400). As discussed later in more detail, there are data showing that diet composition, especially the supplementation with antioxidants, influence the plasma or urinary levels of oxidative stress markers (see sections VI and VII) (48,101,232,247).…”

Section: The Limitations Of Oxidation Markers In Usementioning

confidence: 97%

“…A good example of such enzyme that has compartment-specific isoforms is SOD, and changes in the cytosolic Cu/ZnSOD (SOD1), mitochondrial MnSOD (SOD2), or extracellular SOD (EcSOD; SOD3) activity or expression can be correlated to ROS levels. Elevated MnSOD levels were found in tissues of patients with gastric carcinomas and adenomas (182) as well as squamous cell carcinomas, whereas no significant changes in Cu/ZnSOD were detected (106,391). By contrast, increased Cu/ZnSOD activity was found in tissue samples from patients with colorectal cancer (331), in leukemia patients (400), and in patients with breast cancer (22,288).…”

Section: Compartment-specific Ros Measurementmentioning

confidence: 99%

“…For instance, the levels of catalase, a rather peroxisome-specific antioxidant enzyme, were found to be induced (288), decreased (331), and unaffected (22) in different types of cancer. In line, while high MnSOD expression correlates with a poor prognosis, advanced progression, and an invasive and metastatic phenotype of gastrointestinal tumors (182), it is a factor correlated with favorable survival in patients with buccal mucosal squamous cell carcinomas (106).…”

Section: Compartment-specific Ros Measurementmentioning

confidence: 99%

See 2 more Smart Citations

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Samoylenko

Hossain²,

Mennerich³

et al. 2013

Antioxidants & Redox Signaling

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Reactive oxygen species (ROS) exert various biological effects and contribute to signaling events during physiological and pathological processes. Enhanced levels of ROS are highly associated with different tumors, a Western lifestyle, and a nutritional regime. The supplementation of food with traditional antioxidants was shown to be protective against cancer in a number of studies both in vitro and in vivo. However, recent largescale human trials in well-nourished populations did not confirm the beneficial role of antioxidants in cancer, whereas there is a well-established connection between longevity of several human populations and increased amount of antioxidants in their diets. Although our knowledge about ROS generators, ROS scavengers, and ROS signaling has improved, the knowledge about the direct link between nutrition, ROS levels, and cancer is limited. These limitations are partly due to lack of standardized reliable ROS measurement methods, easily usable biomarkers, knowledge of ROS action in cellular compartments, and individual genetic predispositions. The current review summarizes ROS formation due to nutrition with respect to macronutrients and antioxidant micronutrients in the context of cancer and discusses signaling mechanisms, used biomarkers, and its limitations along with large-scale human trials.

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Section: The Limitations Of Oxidation Markers In Usementioning

confidence: 97%

Section: Compartment-specific Ros Measurementmentioning

confidence: 99%

Section: Compartment-specific Ros Measurementmentioning

confidence: 99%

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Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Samoylenko

Hossain²,

Mennerich³

et al. 2013

Antioxidants & Redox Signaling

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“…There have been conflicting reports on the effects of n-3 polyunsaturated fatty acid supplementation on oxidant/antioxidant status in humans (45,46). Several studies have observed significant associations in head and neck cancer between SOD and GPx activity and better disease-specific survival and postoperative RT (47), between manganese SOD and tumor migration and invasion (48), and between the loss of GPx expression and tumor chemoresistance (49), all important prognostic factors for survival. There is also a deranged antioxidant defense system due to significantly low levels of TAC (50) and higher levels of nitric oxide and GST in these cancer patients, with a significant increase after RT (51).…”

Section: A B C D Ementioning

confidence: 99%

Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients

et al. 2013

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Abstract. Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplement, on markers of inflammation, oxidative stress and metabolic status of ENT cancer patients undergoing radiotherapy (RT). Fourteen days after starting RT, 26 patients were randomly allocated to one of two groups, 13 supplemented with Prosure ® , an oncologic formula enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes (specific supplement), and 13 supplemented with Standard-Isosource ® (standard supplement). Patients were evaluated before RT, and 14, 28 and 90 days after starting RT. The results showed that there were no significant differences between the groups, but greater changes were observed in the standard supplement group, such as a decline in body mass index (BMI), reductions in hematocrit, erythrocyte, eosinophil and albumin levels, and a rise in creatinine and urea levels. We concluded that metabolic, inflammatory and oxidative stress parameters were altered during RT, and began to normalize at the end of the study. Patients supplemented with Prosure showed an earlier normalization of these parameters, with more favorable changes in oxidative stress markers and a more balanced evolution, although the difference was not significant.

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“…The literature indicates an overwhelming evidence of the negative influence of oxidative stress and MnSOD in inflammation and cancer (Fu et al, 2011;Li et al, 2011;Suzuki et al, 2001). Because Mn and iron (Fe) play an important role in the biosynthesis of MnSOD (Hassan & Schrum, 1994), data on the dietary intake of Mn may provide valuable information on possible biochemical requirements for the production and upregulation of MnSOD.…”

Section: Ethnicity and Dietary Antioxidant Intakementioning

confidence: 99%

The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes

MCLEAN¹

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MCLEAN, MICHAEL ANDREW, "The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes" (2014 ), higher energy intake (2148 vs. 1770 kcal), and were more educated as compared to Haitian Americans; all variables were significant at p < .001. Serum levels of 8OHdG and MnSOD for African Americans (1691.0 ± 225.1 pg/ml, 2538.0 ± 1091.8 pg/ml; respectively) were significantly higher than for Haitian Americans (1626Americans ( .2 ± 222.9, 2015.3 pg/ml; respectively). 8OHdG was negatively correlated with MnSOD (r = -.167, p < .001) in T2D. Having T2D was negatively correlated with MnSOD (r = -.337; p < .01) and positively correlated with 8OHdG (r = .500; p < .01). African Americans and Haitian Americans with T2D had fasting plasma glucose (FPG) levels of 143.0 ± 61.0 mg/dl and viii 157.6 ± 65.5 mg/dl, and A1C of 7.5 ± 1.8 % and 8.4 ± 2.4 %, respectively. African Americans and Haitian Americans without T2D had FPG levels of 95.8 ± 13.2 mg/dl and 98.7 ± 16.9 mg/dl, and A1C of 5.9 ± 0.4% and 6.0 ± 0.5%, respectively. Dietary intakes of vitamin C and vitamin D were negatively correlated with FPG (r = -.21; r = -.19, p < .05) respectively. Carotenoids negatively correlated with A1C (r = -.19, p < .05). Lower levels of MnSOD were associated with lower levels of zinc, r = .10, p < .05, and higher levels of carotenoids r = -.10, p < .05. Higher levels of 8OHdG were associated with lower levels of Vitamin D, r = -.14, p < .01, and carotenoids, r = -.09, p < .05.The results demonstrate greater oxidative mtDNA damage in persons with T2D compared to those without T2D and in African Americans compared with Haitian Americans. The inverse relationship between dietary intake of antioxidants and oxidative stress implies a potential to reduce oxidative stress with diet.

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Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas

Abstract: MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC.

Cited by 38 publications

References 38 publications

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients

The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes

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