Manganese species from human serum, cerebrospinal fluid analyzed by size exclusion chromatography-, capillary electrophoresis coupled to inductively coupled plasma mass spectrometry

Michalke, Bernhard; Berthele, Achim; Mistriotis, Panagiotis; Ochsenkühn-Petropoulou, Maria; Halbach, Stefan

doi:10.1016/j.jtemb.2007.09.004

Cited by 55 publications

(29 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Michalke et al found Mn-citrate as the main Mn species in human cerebrospinal fluid (CSF) among other Mn species that could be related to the citric cycle [30,31]. Investigations of metal-species of paired human serum and CSF showed different species pattern and thus, suggests selective permeation of LMM Mn species across the blood-brain and blood-CSF barrier [32].…”

mentioning

confidence: 99%

“…Metabolism of Mn is complex and involves a multiplicity of MnSpecies [31][32][33] with specific behavior in vivo [9,10,12]. Speciation analysis [34] of Mn several days after exposure of the experimental rats could improve understanding of both, the "native" and the "harmful" pathway of Mn within a living organism (rat) and especially the facilitated Mn-influx and accumulation in the brain [10,11].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙4H2O (i.v.)

Diederich

Brielmeier

Schwerdtle

et al. 2012

Microchemical Journal

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙4H2O (i.v.)

Diederich

Brielmeier

Schwerdtle

et al. 2012

Microchemical Journal

View full text Add to dashboard Cite

“…by carrier-mediated processes, and most Mn 2? ions are chelated by citrate in the extracellular space of the brain [8,9]. Based on their molecular size, Mn-citrate and Mn-bicine may not enter the cells themselves.…”

Section: Discussionmentioning

confidence: 99%

“…can pass the ependymal layer of the ventricles [7], and part of the Mn 2? may bind with citrate and bicarbonate in the interstitial fluid [8,9], we have to consider the sum of diffusion of more than four types of manganese. In this text, ''manganese'' refers to all of these types.…”

Section: Introductionmentioning

confidence: 99%

Lateral diffusion of manganese in the rat brain determined by T1 relaxation time measured by 1H MRI

et al. 2011

View full text Add to dashboard Cite

In order to optimize manganese ion-enhanced MRI in thalamic and hypothalamic nuclei, we analyzed the diffusion of manganese in the brain followed by the intra-cerebroventricular application of manganese-bicine (Mn-bicine). T(1)-weighted MRI intensities, with 9-pixel ROIs in the hypothalamus perpendicular to the third ventricle, were measured during continuous infusion of Mn-bicine solution in the lateral cerebroventricle. Using a relationship between the image intensity of T(1)-weighted MRI and T(1) relaxation time, the image intensity was converted into the concentration of manganese. Assuming a simple diffusion process, the apparent diffusion coefficient (D (ap)) of manganese (4.2 × 10(-5) mm(2) s(-1)) is much lower than that of water (6 × 10(-4) mm(2) s(-1)), and the D (ap) tended to decrease when the distance from the third ventricle increased. These results suggest (1) the Mn(2+) ion is trapped by neural cells during diffusion and (2) the manganese efflux is discharged from the brain via veins.

show abstract

“…High exposure to Mn may lead to a Parkinson-like disease pattern. Recent studies have shown that Mn in CSF is mostly bound to low-molecular mass carriers in the range 640-680 Da [28] . When testing several possible Mn carriers, the most abundant Mn species was Mn-citrate [29] .…”

Section: Discussionmentioning

confidence: 99%

Concentrations of Metals, β-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer’s Disease

Gerhardsson

Blennow²,

Lundh³

et al. 2009

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: In this study, metal concentrations were related to the levels of well-known Alzheimer markers in cerebrospinal fluid (CSF), such as amyloid-beta (Aβ), total tau (T-tau) and phosphorylated-tau (P-tau). Methods: Concentrations of 19 metals (Mg, Ca, V, Mn, Fe, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Hg and Pb by inductively coupled plasma-mass spectrometry) and the levels of Aβ, T-tau and P-tau in CSF were determined (xMAP technology) in 264 patients with Alzheimer‘s disease (AD), and in 54 healthy referents. Results: The AD subjects showed positive correlations between CSF-T-tau and CSF-P-tau versus CSF-Mn (r_s = 0.22, p = 0.004; r_s = 0.18, p = 0.021). CSF-T-tau, however, showed a negative correlation with CSF-Cs (r_s = –0.17; p = 0.027). In subjects with severe AD, CSF-Aβ showed a strong positive correlation with CSF-Cs (r_s = 0.49; p = 0.026), while CSF-T-tau showed a strong negative correlation with CSF-Cs (r_s = –0.49; p = 0.026). Also, CSF P-tau was negatively associated with CSF-Cs (r_s = –0.41; p = 0.06). Conclusion: The different relationships between the CSF-levels of Aβ and tau-markers versus the levels of CSF-Mn and CSF-Cs may be due to different binding affinity between these metals and metal binding proteins in the CSF and the surrounding brain.

show abstract

Manganese species from human serum, cerebrospinal fluid analyzed by size exclusion chromatography-, capillary electrophoresis coupled to inductively coupled plasma mass spectrometry

Cited by 55 publications

References 14 publications

Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙4H2O (i.v.)

Manganese and iron species in Sprague–Dawley rats exposed with MnCl2∙4H2O (i.v.)

Lateral diffusion of manganese in the rat brain determined by T1 relaxation time measured by 1H MRI

Concentrations of Metals, β-Amyloid and Tau-Markers in Cerebrospinal Fluid in Patients with Alzheimer’s Disease

Contact Info

Product

Resources

About