1999
DOI: 10.1515/reveh.1999.14.4.251
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Manganese Retention in Rat Brain

Abstract: Manganese retention was observed in brains and in several other tissues of female Wistar rats after the intratracheal instillation of an inorganic manganese compound: manganese dioxide. Two categories of rats, younger (180 to 200g) and older (330 to 350g), were divided into a control group, in which animals received vehicle only (0.5 mL physiological saline), and an experimental group, in which rats received a dose of 0.48 mg of Mn/kg body weight (in 0.5 mL saline), twice a week for 3 months, for a total dosag… Show more

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Cited by 3 publications
(2 citation statements)
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“…Mn is known to be distributed and taken up by specialized neurons and is thought to play an important role in brain development and metabolism. 20 In order to demonstrate the acute distribution of Mn in brain, an experiment involving intraperitoneal injection of Mn was performed. Mn was continuously measured in brain of living rat during administration of MnCl 2 .…”
Section: In Vivo Studymentioning
confidence: 99%
See 1 more Smart Citation
“…Mn is known to be distributed and taken up by specialized neurons and is thought to play an important role in brain development and metabolism. 20 In order to demonstrate the acute distribution of Mn in brain, an experiment involving intraperitoneal injection of Mn was performed. Mn was continuously measured in brain of living rat during administration of MnCl 2 .…”
Section: In Vivo Studymentioning
confidence: 99%
“…Manganese (Mn) is one of the essential trace elements required for living organisms for certain physiological functions such as brain development and metabolism. 20 Mn is also a metal of toxicological concern mainly because chronic overexposure may lead to toxic effects in the central nervous system (CNS). 21 The deficiency or excess of Mn is known to cause neurotoxicity in experimental animals and man.…”
Section: Introductionmentioning
confidence: 99%