Manganese pre-treatment attenuates cadmium induced hepatotoxicity in Swiss albino mice

Chaudhary, Shaista; Iram, Sidra; Raisuddin, Sheikh; Parvez, Suhel

doi:10.1016/j.jtemb.2014.06.013

Cited by 18 publications

(19 citation statements)

References 34 publications

(31 reference statements)

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“…In support of this role, some divalent metals such as zinc, selenium and manganese have been shown to antagonize and prevent cadmium-induced cytotoxicity. [7][8][9] Several studies have investigated a number of agents which have potentials to counteract cadmium-mediated toxicity. Some of these agents including blueberry, curcumin, caffeic acid phenethyl ester, etc have been shown to be effective in preventing cadmium toxicity.…”

Section: Introductionmentioning

confidence: 99%

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

2016

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Section: Introductionmentioning

confidence: 99%

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

2016

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“…It was shown that the pretreatment of mice with a single dose of Mn (20 mg/kg bw, i.p.) 24 hours before Cd intoxication (7 mg/kg bw, s.c.) decreased the level of TBARS in the liver even compared to the control group (Chaudhary et al, ). Mn completely attenuated an increase in the activity of nicotinamide adenine dinucleotide phosphate oxidase caused by Cd and partially prevented this xenobiotic‐generated decrease in the concentration of GSH and non‐protein thiols in the liver.…”

Section: Non‐phenolic Substances In Protection From CD Hepatotoxicitymentioning

confidence: 96%

“…Although, Cd is not a redox‐active metal, it mediates in the production of ROS, including hydrogen peroxide (H 2 O 2 ), superoxide radical (O 2 · – ) and hydroxyl radical ( · OH), indirectly through weakening the enzymatic (e.g., catalase [CAT], superoxide dismutase [SOD], glutathione peroxidase [GPx], glutathione reductase [GR]) and non‐enzymatic (e.g., small molecule antioxidants: reduced glutathione [GSH], vitamins C and E) antioxidative barrier of hepatocytes (Amamou et al, ; El‐Boshy et al, ; Gong et al, ; Pari & Shagirtha, ; Renugadevi & Prabu, ; Sakr et al, ). Furthermore, Cd induces the activity of oxidases, including inducible nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase and cyclooxygenase‐2 (Chaudhary et al, ).…”

Section: Mechanism Of CD Hepatotoxicitymentioning

confidence: 99%

“…Fe is an essential trace element required for the activity of CAT, Se‐Cd complexes are responsible for the disruption of GPx activity, while the interaction of this xenobiotic with Cu, Zn and Mn alters the proper function of SOD. Experimental investigations reported that Cd‐induced changes in the concentration of Zn, Se and Fe in the liver correlate with a decrease in the activity of antioxidative enzymes in this organ (Chaudhary et al, ; El‐Boshy et al, ; Gałażyn‐Sidorczuk et al, ; Jamakala & Rani, ; Rogalska et al, ), while Cd‐caused elevation of intracellular Ca plays an important role in the apoptosis of hepatocytes (Wang et al, ).…”

Section: Mechanism Of CD Hepatotoxicitymentioning

confidence: 99%

“…Mn completely attenuated an increase in the activity of nicotinamide adenine dinucleotide phosphate oxidase caused by Cd and partially prevented this xenobiotic‐generated decrease in the concentration of GSH and non‐protein thiols in the liver. The exposure to Cd increased the activity of GR in this organ, whereas pre‐administration of Mn completely prevented this parameter rise (Chaudhary et al, ). Eybl and Kotyzová () have reported that the administration of manganese chloride · 4H 2 O 20 mg/kg bw, 24 hours before an injection of a single dose of CdCl 2 · 2.5H 2 O 7 mg/kg bw to mice attenuated Cd‐induced lipid peroxidation and prevented the depletion of hepatic GSH.…”

Section: Non‐phenolic Substances In Protection From CD Hepatotoxicitymentioning

confidence: 99%

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Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Mężyńska

Brzóska

2018

J of Applied Toxicology

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Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.

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Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

Mężyńska

Brzóska

2017

Environ Sci Pollut Res

230

129

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Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking. Recent epidemiological studies have provided numerous evidence that even low-level environmental exposure to this toxic metal, nowadays occurring in numerous economically developed countries, creates a risk for health of the general population. The low-level lifetime exposure to this metal may lead to the damage to the kidneys, liver, skeletal system, and cardiovascular system, as well as to the deterioration of the sight and hearing. Moreover, it has been suggested that environmental exposure to this xenobiotic may contribute to the development of cancer of the lung, breast, prostate, pancreas, urinary bladder, and nasopharynx. Taking the above into account, the aim of this review article is to draw more attention to Cd as an environmental risk factor for the health of the general population and the need to undertake preventive actions allowing to reduce the risk of health damage due to a lifetime exposure to this toxic metal.

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Manganese pre-treatment attenuates cadmium induced hepatotoxicity in Swiss albino mice

Cited by 18 publications

References 34 publications

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

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