Manganese porphyrin/ICG nanoparticles as magnetic resonance/fluorescent dual-mode probes for imaging of sentinel lymph node metastasis

Abstract

Diagnosis of sentinel lymph node (SLN) metastasis and its status are key parameters for predicting overall disease prognosis. In this work, Pluronic F127 stabilized ICG/tetra(4-carboxyphenyl)porphyrin-Mn(III) (TCPP(Mn)) nanoparticles (F127-ICG/Mn NPs) as...

A TMVP1-modified near-infrared nanoprobe: molecular imaging for tumor metastasis in sentinel lymph node and targeted enhanced photothermal therapy

“…7 C and D) for popliteal lymph node metastasis group of both 4T1 and MS751. Different from previous studies, the maximum fluorescence intensity value caused by polypeptide-mediated active targeting appeared later than that of EPR [ 56 ]. Statistical analysis suggested no statistically significance (Fig.…”

Relaxivity Enhancement of Hybrid Micelles via Modulation of Water Coordination Numbers for Magnetic Resonance Lymphography

“…33 The increased SSA of the micelles with decreasing size implies that there may be more Mn ions on the surface to coordinate with water molecules, thus the relaxivity increases. 34,35 On the contrary, with the introduction of ZnL, less DSPE-PEG2000 is presented in micelle formulation, leading to enlarged micelle size, and parts of ZnL and MnL may be encapsulated within micelles, 36 while the encapsulated Mn ions have few capabilities to interact with water molecules, causing the q value of the Mn ions in the entire micelle to decrease, resulting in relaxivity reduction. What is the relevance between the doping density of paramagnetic Mn ions, q, and relaxivities in hybrid micelles?…”

“…The results indicate that relaxivities are negatively correlated with sizes under the condition of constant Mn content, which may be related to the specific surface area (SSA) of micelles (Figure D,E, Tables S4 and S5). The increased SSA of the micelles with decreasing size implies that there may be more Mn ions on the surface to coordinate with water molecules, thus the relaxivity increases. , On the contrary, with the introduction of ZnL, less DSPE-PEG2000 is presented in micelle formulation, leading to enlarged micelle size, and parts of ZnL and MnL may be encapsulated within micelles, while the encapsulated Mn ions have few capabilities to interact with water molecules, causing the q value of the Mn ions in the entire micelle to decrease, resulting in relaxivity reduction.…”

Kinetically inert manganese (II)-based hybrid micellar complexes for magnetic resonance imaging of lymph node metastasis

“…Among various routes of tumor metastasis, lymphogenous metastasis is a common way, and the first lymph nodes (LNs) invaded by tumor cells are the sentinel lymph nodes (SLNs) [ 1–3 ]. In breast cancer patients, the localization and diagnosis of SLNs are important to surgical planning and prognosis [ 4 ]. In current clinical practice, localization of the SLNs during surgery by means of dyes (such as methylene blue, iso-sulfan blue and Patent Blue V ® ) or radioactive labeling tracers (such as technetium 99 sulfur colloids and Lymphoseek ® ) and intraoperative biopsy to differ LN metastasis, which increases the complexity of the procedure and leads to prolonged operative time and may result in surgical complications [ 2 ].…”

“…In the last two decades, a variety of magnetic resonance (MR) contrast agents have been developed and explored for their use in LN imaging [ 4 , 16–18 ]. Nanoparticles have an inherent ability to localize LNs due to their property of accumulating in LNs with the flow of lymph fluid [ 19–22 ].…”