Manganese Metabolism in College Women

North, Barbara B.; Leichsenring, Jane M.; Norris, Loana M.

doi:10.1093/jn/72.2.217

Cited by 26 publications

(5 citation statements)

References 8 publications

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“…McLeod and Robinson [17] have reported that the manganese absorption rate was ~ 12% for meatloaf, ice cream, and tea. However, North et al [18] showed that the absorption rate was 50% for the group on a low-protein and high-vegetable diet, while Mena et al [19] indicated that the absorption rate of manganese for healthy adults is only 3 -4%. Likewise, there is no consistent result on manganese absorption rate, which calls for continuous research on this issue.…”

Section: Discussionmentioning

confidence: 99%

Estimated balance status of manganese in healthy young adults

Kim¹,

Kim²,

Choi³

2013

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Manganese is an essential nutrient for human metabolism; however, few studies have been conducted to establish the dietary recommended intake (DRI) for manganese. The purpose of this study is to provide data that ean inform the manganese intake level and address the RI by analyzing the manganese intake of 513 young Korean adults and evaluating the blood levels and estimated .manganese balanee of 51 selected subjects. The average age of the total subjects was 22.6 years for men and 21.6 years for women. The average daily energy intake was 1,758.50 kcal for men and 1,578.5 kcal for women. " In addition, the daily manganese intake was 3,772.7 |ig for men and 3,444.2 Hg for women. The manganese intake of all subjects was lower than the tolerable upper intake. The manganese intake, excretion through urine and feces, retention amount, and retention rate of the selected subjects were 2,922.8 ng, 2,612.2 ng, 331.1 ^g, and 6.7%, respectively, with no significant difference between men and women except urinary excretion (0.34 iigfor men vs. 0.1841g for women, p < 0.05). The manganese intake was positively related with the ' intakes of food, energy, protein, fat, and carbohydrate. Also, the manganese retention amount was positively related with the intakes of energy, protein, and fat. These results show that both food intake and energy intake are important factors for manganese intake and retention.

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Section: Discussionmentioning

confidence: 99%

Estimated balance status of manganese in healthy young adults

Kim¹,

Kim²,

Choi³

2013

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“…The amount of Mn stored in the body of a 70 kg adult man 11 is approximately 12-20 mg. Manganese is absorbed into the intestinal cell by the binding of Mn 31 to the transferrin-transferrin receptor (Tfr) complex. Endocytosis brings about internalization of the complex, Mn 31 -transferrinTfr, 12 with the subsequent dissociation of Mn 31 into Mn 21 . The resultant Mn 21 and proton are then transported into the cytosol by the divalent metal transporter-1 (DMT-1).…”

Section: Absorption Transport and Excretionmentioning

confidence: 99%

“…Endocytosis brings about internalization of the complex, Mn 31 -transferrinTfr, 12 with the subsequent dissociation of Mn 31 into Mn 21 . The resultant Mn 21 and proton are then transported into the cytosol by the divalent metal transporter-1 (DMT-1). 13 The protein, ferroportin, which is responsible for export of Fe from the cell, has been implicated in cytoplasmic Mn efflux as well.…”

Section: Absorption Transport and Excretionmentioning

confidence: 99%

“…An early study by North et al (1960) found that college women fed conventional diets, with a mean Mn intake of 3.7 mg per day, exhibited Mn balance of 1.54 mg per day and retention of 41% (Table 2.1). 21 In college men who were vegetarians and consumed their self-selected diets, Lang et al (1965) found that a higher Mn intake of 7.07 mg per day resulted in a positive Mn balance of 3.34 mg per day and retention of 47%.…”

Section: Adult Dietsmentioning

confidence: 99%

“…21 In college men who were vegetarians and consumed their self-selected diets, Lang et al (1965) found that a higher Mn intake of 7.07 mg per day resulted in a positive Mn balance of 3.34 mg per day and retention of 47%. 22 In 1984, Patterson et al examined Mn dietary levels over the course of one year in 28 young adult men and women.…”

Section: Adult Dietsmentioning

confidence: 99%

See 2 more Smart Citations

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

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Manganese (Mn) is a ubiquitous trace mineral that is essential for living organisms. This mineral is a cofactor of enzymes such as superoxide dismutase and arginase. It assumes a significant role in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone, digestion, and development. Food sources include whole grains, cereals, green leafy vegetables, nuts, and tea. Approaches to assess Mn requirements include metabolic balance, blood levels, and response of biomarkers. In the United States, the adequate intake (AI) of Mn is 1.8 and 2.3 mg day−1 for women and men, respectively. Negative balance has been reported in numerous studies, where Mn intake was greater than the AI; thus, the adequacy of current dietary recommendations is unclear. Factors that influence Mn requirements include life stage and gender, bioavailability (fiber, phytates, mineral interactions, polyphenolic compounds), and international considerations. Deficiency of Mn has been associated with adverse health conditions including dermatitis, osteoporosis, dyslipidemia, diabetes, metabolic syndrome, hypertension, epilepsy, cancer, asthma, problems with cognitive function, and poor birth outcomes. Toxicity of Mn may be a potential problem with contaminated drinking water, parenteral nutrition, individuals with hepatic dysfunction, and soy formula-fed infants. An understanding of Mn nutrient requirements is important for achievement of optimal health.

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Effects of Trace Elements on Immunoregulation

Flynn

1985

Pharmacology

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Manganese Metabolism in College Women

Cited by 26 publications

References 8 publications

Estimated balance status of manganese in healthy young adults

Estimated balance status of manganese in healthy young adults

Nutritional Requirements for Manganese

Effects of Trace Elements on Immunoregulation

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