Manganese induced testicular changes in monkeys

Murthy, Ramesh; Srivastava, Roshni; Gupta, S.K.; Chandra, Satya V.

doi:10.1016/s0014-4908(80)80054-8

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…The harmful effect of MgCl2 on postnatal spermatogenesis was evidently concluded in previous experimental researches (13) .…”

Section: Discussionmentioning

confidence: 65%

“…Manganese compounds proved to decrease testicular weight and to produce necrosis of the seminiferous tubules after oral administration to adult experimental animals (13) . In support to the results of this study, it was reported that manganese compounds produce delay in postnatal sexual maturation in male mice associated with histological changes in the testes including congestion and seminiferous tubular necrosis (15,16) .…”

Section: Discussionmentioning

confidence: 97%

“…The control group of pregnant female mice was given 0.1 ml of distilled water orally. The experimental group was given a sub-lethal dose of 8000 mg/L MgCl2 solution (13) . This solution was administered orally to the pregnant mice through oro-gastric intubation (polyethylene catheter fitted to a 1ml hypodermic syringe).…”

Section: Methodsmentioning

confidence: 99%

“…The toxicity of manganese was reported to be mainly affected the central nervous system, mainly the hypothalamus (10) . Also, the toxicity of manganese was suggested to affect the gastric mucosa (11) , and affected the hemoglobin synthesis (12) , and affecting testicular development (13) . The aim of this study is to investigate the effect of exposure to MnCl2 sub-lethal dose during prenatal development of the mice testes using MDA antibody as an immunohistochemical marker.…”

Section: Immunohistochemical Malondialdehyde Antibodies Changes Of Thmentioning

confidence: 99%

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Immunohistochemical Malondialdehyde Antibodies Changes of the Adult Mice Testes Affected by Prenatal Manganese Chloride Exposure

2017

IJMS

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Background The harmful effect of manganese chloride on postnatal spermatogenesis was evidently concluded in previous experimental researches, however, the molecular changes related to this effect of manganese chloride needs further elaboration. Objective To investigate the toxic effect of prenatal manganese chloride exposure on adult mice testes using malondialdehyde (MDA) antibodies as an immunohistochemical marker. Methods In this study, 30 pregnant mice were divided into control and experimental groups. The experimental animals were given 0.1 ml of manganese chloride solution (8000 mg/Liter concentration) orally during the first 17 days of pregnancy. The control group of pregnant mice was given 0.1 ml of distilled water orally rather than the solution of manganese chloride. Paraffin sections of the offspring mice testes were stained for general histological features and for anti-MDA immunohistochemical evaluation. The Aperio Image Scope v.9 software was used to evaluate the immunohistochemical reaction. Results Sections of testes from mice of the experimental group showed distorted morphology and organization of the stages of sperm development with distorted histological criteria of the interstitial tissue. Results from mice testes revealed statistically significant variability of antimalondialdehyde (MDA) immunohistochemical expression in the experimental group compared to that of the control group. Conclusion Manganese chloride induced lipid peroxidation as part of its toxic effect. This lipid peroxidation caused cellular injury leading to apoptosis and autophagy.

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“…The harmful effect of MgCl2 on postnatal spermatogenesis was evidently concluded in previous experimental researches (13) .…”

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Immunohistochemical Malondialdehyde Antibodies Changes Of Thmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Malondialdehyde Antibodies Changes of the Adult Mice Testes Affected by Prenatal Manganese Chloride Exposure

2017

IJMS

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“…There is some evidence that exposure to Mn can adversely affect male reproductive function in experimental animals (3)(4)(5)27,37), and epidemiological studies of occupationally exposed men have also shown reductions in the average number of children per family (22), and diminished libido and impotence (25). However, these adverse effects on male reproductive function are generally seen only after exposure to excessive amounts of Mn for long periods, resulting in exposure to far greater amounts of Mn than are contained in a single clinical dose of MnDPDP.…”

Section: Discussionmentioning

confidence: 99%

The reproductive toxicology of intravenously administered MnDPDP in the rat and rabbit

Grant¹,

Blazak²,

Brown³

1997

Acta Radiol

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Purpose: The reproductive toxicology of mangafodipir trisodium (MnDPDP, Teslascan), a new hepatobiliary MR contrast agent, was evaluated in rats and rabbits.Material and Methods: Male and female fertility and post-natal development were examined in rats after repeated i.v. injections of MnDPDP. The developmental toxicity in rats was investigated after repeated daily i.v. injections during organogenesis with MnDPDP, MnCl,, or DPDP, as well as with MnC1, administered orally. The developmental toxicity of i.v. injected MnDPDP was also investigated in rabbits.Results: MnDPDP (100 pmofig) had no adverse effects on rat fertility. However, both MnDPDP (10-40 pmolkg) and MnCl, (30 pmofig) caused skeletal abnormalities in the rat, but not in the rabbit given 20 pmol MnDPDPkg. Maternal treatment of rats with MnDPDP (40 prnofig) reduced survival and body weights of neonates, and adversely affected their functional, but not physical development. No skeletal abnormalities were seen in the rat after i.v. administered DPDP (40 pmolkg) or MnCl, (6 pmofig), or after MnC1, (400 pmolkg) given by oral gavage. Maternal toxicity was not seen in rats or rabbits given these doses.Conclusion: MnDPDP caused skeletal abnormalities in foetal rats, but not rabbits, and had no effects on rat fertility. Manganese appears to be the causative agent for inducing bone abnormalities in the rat.There has been considerable interest in developing manganese-(Mn) based contrast agents for MR imaging, due its paramagnetic properties and effects on the relaxivity of those tissues that take it up (17,18,38,50). One such agent is manganese(I1) dipyridoxy1 diphosphate (MnDPDP), a chelate of Mn and an organic ligand, dipyridoxyl diphosphate (fodipir, DPDP) (43), which has been formulated as the MR contrast agent, mangafodipir trisodium infusion 0.01 mmol/ml. MnDPDP has been shown to have good efficacy for the detection and characterization of focal liver lesions, both in humans (33)(34)(35)46) and in experimental animals (28-31). The recommended single clinical dose of MnDPDP is 5 pmoV kg b.w.After i.v. administration, MnDPDP is metabolized by dephosphorylation and simultaneous trans-

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Mangan

Steffen¹,

Stommel²

2012

Vitamine Und Spurenelemente

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Manganese induced testicular changes in monkeys

Cited by 9 publications

References 7 publications

Immunohistochemical Malondialdehyde Antibodies Changes of the Adult Mice Testes Affected by Prenatal Manganese Chloride Exposure

Immunohistochemical Malondialdehyde Antibodies Changes of the Adult Mice Testes Affected by Prenatal Manganese Chloride Exposure

The reproductive toxicology of intravenously administered MnDPDP in the rat and rabbit

Mangan

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