Manganese‐induced parkinsonism responsive to intranasal insulin: A case report

Salari, Mehri; Etemadifar, Masoud; Dargahi, Leila; Valian, Neda; Rezaee, Malihe

doi:10.1002/ccr3.5562

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…For a long time, there has been some controversy about Mn-induced dopaminergic alterations; whereas some researchers reported that Mn alters dopaminergic innervation, particularly in the basal ganglia, and produces Parkinson-like disorder [14][15][16][17][18] many authors suggested that Mn neurotoxicity is unlike from PD in symptoms, pathology, and etiology [18,19], particularly in the evident preservation of SNc dopaminergic somas [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models

Avila-Costa¹,

Ordóñez-Librado²,

Gutiérrez-Valdez³

et al. 2023

Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials

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The knowledge about the biochemical and behavioral changes in humans with PD has allowed proposing animal models for its study; however, the results obtained so far have been heterogeneous. Recently, we established a novel PD model in rodents by manganese chloride (MnCl2) and manganese acetate (Mn (OAc)3) mixture inhalation. After inhaling, the rodents presented bilateral loss of SNc dopaminergic neurons. Later, we conclude that the alterations are of dopamine origin since L-DOPA reverted the alterations. After six months, SNc significantly reduced the number of cells, and striatal dopamine content decreased by 71%. The animals had postural instability, action tremor, and akinesia; these symptoms improved with L-DOPA, providing evidence that Mn mixture inhalation induces comparable alterations that those in PD patients. Thus, this study aimed to compare the alterations in two different PD experimental models: 6-OHDA unilateral lesion and Mn mixture inhalation through open field test, rotarod performance and the number of SNc dopaminergic neurons. The results show that the Mn-exposed animals have motor alterations and bilateral and progressive SNc neurons degeneration; in contrast, in the 6-OHDA model, the neuronal loss is unilateral and acute, demonstrating that the Mn exposure model better recreates the characteristics observed in PD patients.

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