Manganese-induced neurodegenerative diseases and possible therapeutic approaches

Martins, Airton C.; Gubert, Priscila; Boas, Gustavo Roberto Villas; Paes, Marina Meirelles; Santamarı́a, Abel; Lee, Eun-Sook; Tinkov, Alexey A.; Bowman, Aaron B.; Aschner, Michael

doi:10.1080/14737175.2020.1807330

Cited by 38 publications

(18 citation statements)

References 159 publications

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“…These histological and stain findings, which are characteristic of Zr skin lesions and granulomas, suggest Zr interstitial lung disease. Researchers (e.g., Cabral Pinto, et al, 2019; Mezzaroba, et al, 2019; Martins, et al, 2020; Soares, et al, 2020; Ajsuvakova, et al, 2020; Exley & Clarkson, 2020; McDonald, et al, 2021; Xu et al, 2021; Capriello, et al, 2021; Ravanfar, et al, 2021)) are working on exposure of other (heavy) metal (e.g., Al, Fe, and Mn) linked to neurological disorders and diseases, such Alzheimer and Parkinson diseases. The map distribution of HI is presented in Figure 6, with all samples above the target value of 1.…”

Section: Resultsmentioning

confidence: 99%

“…Liu, et al (2017) described a nonsmoking ceramic tile worker who developed a sarcoid granulomatosis type of chronic pulmonary hypersensitivity reaction after long-term exposure to Zr and causes an acute and fulminant allergic alveolitis. Romeu, et al (1992) found interstitial lung Pinto, et al, 2019;Mezzaroba, et al, 2019;Martins, et al, 2020;Soares, et al, 2020;Ajsuvakova, et al, 2020;Exley & Clarkson, 2020;McDonald, et al, 2021;Xu et al, 2021;Capriello, et al, 2021;Ravanfar, et al, 2021)) are working on exposure of other (heavy) metal (e.g., Al, Fe, and Mn) linked to neurological disorders and diseases, such Alzheimer and Parkinson diseases. The map distribution of HI is presented in Figure 6, with all samples above the target value of 1.…”

Section: Spatial Variation Of Ecological and Human Risksmentioning

confidence: 99%

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Baseline maps of potentially toxic elements in the soils of Garhwal Himalayas, India: Assessment of their eco‐environmental and human health risks

et al. 2021

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Geochemical mapping is frequently used to identify the regions of the Planet with critical chemical elements and their natural or anthropogenic sources. In order to understand elements' geochemistry and to identify the area's potentially harmful associations, high‐resolution maps of chemical elements, physico‐chemical parameters, a noncarcinogenic hazard index, and a potential ecological risk index were modelled with soil samples collected in the Himalaya region. It is the first environmental and geochemical atlas for this region. It was found that natural processes are determining the distribution of the variable in this area. The granulometric features seem to be strongly influenced by land use, with coarser grain sizes in forest soils, contrasting with the finer grain sizes in agricultural soils. The map distribution of the noncarcinogenic hazard index showed that there is an expected hazard for some variables for both children and adults. Potential ecological risk is revealed to be low to moderate. Remediation of contaminated soils is necessary to reduce the associated risks, make the land resource available for agricultural production, enhance food security, and scale down land tenure problems arising from changes in the land use pattern. This study is subsequent implementation of natural‐based approaches to system stability in largely unspoilt area.

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Section: Resultsmentioning

confidence: 99%

Section: Spatial Variation Of Ecological and Human Risksmentioning

confidence: 99%

Baseline maps of potentially toxic elements in the soils of Garhwal Himalayas, India: Assessment of their eco‐environmental and human health risks

et al. 2021

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“…We also report that in BMEC cultures, Co and Mn in conjunction with each of the three organic compounds were significantly more toxic than the corresponding organic compound alone. Mn neurotoxicity has been well studied [53][54][55]. In fact, using RBE cells, a rat brain endothelial cell line, dos Santos and colleagues showed that Mn demonstrated significant toxicity in a dose range of 200-800 µM and concluded that Mn induced mitochondrial injury in these cells [56].…”

Section: Discussionmentioning

confidence: 99%

Effects of Incubation of Human Brain Microvascular Endothelial Cells and Astrocytes with Pyridostigmine Bromide, DEET, or Permethrin in the Absence or Presence of Metal Salts

Hoffman

Kalinich

2020

IJERPH

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Gulf War Illness (GWI) is a chronic, multi-symptom illness suffered by over one-third of American military veterans who served in the Persian Gulf War between 1990 and 1991. No current single-exposure scenario accounts for all the symptoms observed in GWI, and instead may be due to a multi-exposure scenario. As a larger effort to understand how one category of multi-exposure scenarios of organic compounds such as nerve gas prophylactic pyridostigmine bromide, or insecticides/pesticides such as N,N-diethyl-m-toluamide (DEET) and permethrin, plus heavy metals found in inhaled dust particles (Al, Fe, Ni, Sr, DU, Co, Cu, Mn, and Zn) might play a role in neural aspects of GWI, we begin this initial study to examine the toxicity and oxidative damage markers of human brain endothelial cell and human astrocyte cell cultures in response to these compounds. A battery of cytotoxicity assessments, including the MTT assay, Neutral Red uptake, and direct microscopic observation, was used to determine a non-toxic dose of the test compounds. After testing a wide range of doses of each compound, we chose a sub-toxic dose of 10 µM for the three organic compounds and 1 µM for the nine metals of interest for co-exposure experiments on cell cultures and examined an array of oxidative stress-response markers including nitric oxide production, formation of protein carbonyls, production of thiobarbituric acid-reactive substances, and expression of proteins involved in oxidative stress and cell damage. Many markers were not significantly altered, but we report a significant increase in nitric oxide after exposure to any of the three compounds in conjunction with depleted uranium.

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“…The role of Mn 2+ in the etiology of neurodegenerative diseases has been widely documented. Excess Mn 2+ was shown to induce a neurological disorder with symptoms similar to PD [ 206 ]. Moreover, Mn 2+ contributed to AD associated with impaired cognitive function and cognitive decline [ 207 ].…”

Section: Secretory Pathway Ca 2+ -Atpase (Spca)mentioning

confidence: 99%

Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases

Boczek

Sobolczyk

Mackiewicz

et al. 2021

IJMS

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Calcium in mammalian neurons is essential for developmental processes, neurotransmitter release, apoptosis, and signal transduction. Incorrectly processed Ca2+ signal is well-known to trigger a cascade of events leading to altered response to variety of stimuli and persistent accumulation of pathological changes at the molecular level. To counterbalance potentially detrimental consequences of Ca2+, neurons are equipped with sophisticated mechanisms that function to keep its concentration in a tightly regulated range. Calcium pumps belonging to the P-type family of ATPases: plasma membrane Ca2+-ATPase (PMCA), sarco/endoplasmic Ca2+-ATPase (SERCA) and secretory pathway Ca2+-ATPase (SPCA) are considered efficient line of defense against abnormal Ca2+ rises. However, their role is not limited only to Ca2+ transport, as they present tissue-specific functionality and unique sensitive to the regulation by the main calcium signal decoding protein—calmodulin (CaM). Based on the available literature, in this review we analyze the contribution of these three types of Ca2+-ATPases to neuropathology, with a special emphasis on mental diseases.

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Manganese-induced neurodegenerative diseases and possible therapeutic approaches

Cited by 38 publications

References 159 publications

Baseline maps of potentially toxic elements in the soils of Garhwal Himalayas, India: Assessment of their eco‐environmental and human health risks

Baseline maps of potentially toxic elements in the soils of Garhwal Himalayas, India: Assessment of their eco‐environmental and human health risks

Effects of Incubation of Human Brain Microvascular Endothelial Cells and Astrocytes with Pyridostigmine Bromide, DEET, or Permethrin in the Absence or Presence of Metal Salts

Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases

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