Manganese in Health and Disease

Ávila, Daiana Silva; Puntel, Robson Luiz; Aschner, Michael

doi:10.1007/978-94-007-7500-8_7

Cited by 229 publications

(162 citation statements)

References 231 publications

(364 reference statements)

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“…Manganese has been found directly to impair oxidative metabolism and interfere with mitochondrial Ca 2C homeostasis (for a review see ref. 38 ). As DMT1 levels increase in substantia nigra cells in PD, 39 the potential DMT1-mediated transition metal overload of mitochondria in PD expected from mitochondrial DMT1 localization may thus affect mitochondrial function by mechanisms in addition to oxidative stress.…”

Section: Dmt1 Is Well Known As An Fementioning

confidence: 99%

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

et al. 2014

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Section: Dmt1 Is Well Known As An Fementioning

confidence: 99%

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

et al. 2014

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“…However, when over-deposited in the brain, manganese promotes neurotoxicity, which is characterized by memory loss, impaired motor coordination and psychotic behavior resembling Parkinson’s disease (Avila et al, 2013). Manganese absorption from the gastrointestinal tract is limited due to first-pass elimination via biliary excretion (Roth, 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis

Kim

2015

Environmental Toxicology and Pharmacology

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Manganese in excess promotes unstable emotional behavior. Our previous study showed that olfactory manganese uptake into the brain is altered in Hfe−/− mice, a model of iron overload hemochromatosis, suggesting that Hfe deficiency could modify the neurotoxicity of airborne manganese. We determined anxiety-related behavior and monoaminergic protein expression after repeated intranasal instillation of MnCl2 to Hfe−/− mice. Compared with manganese-instilled wild-type mice, Hfe−/− mice showed decreased manganese accumulation in the cerebellum. Hfe−/− mice also exhibited increased anxiety with decreased exploratory activity and elevated dopamine D1 receptor and norepinephrine transporter in the striatum. Moreover, Hfe deficiency attenuated manganese-associated impulsivity and modified the effect of manganese on the expression of tyrosine hydroxylase, vesicular monoamine transporter and serotonin transporter. Together, our data indicate that loss of HFE function alters manganese-associated emotional behavior and further suggest that HFE could be a potential molecular target to alleviate affective disorders induced by manganese inhalation.

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“…Alternatively, Mn complexes might interact more strongly to DNA than Co ones. On the one hand, it is unlikely that the observed variation in the genotoxicity could be attributed to the type of metal in the complexes, since Mn ion is present inside cells and is required for the activity of several enzymes (Avila et al, 2013). The results that the mutagenicity of MnSL1 and CoSL1 decreases at higher concentrations might indicate that these complexes are cytotoxic to cells at high doses.…”

Section: Discussionmentioning

confidence: 93%

Synthesis, characterization and biological activity of some unsymmetrical Schiff base transition metal complexes

Esmadi

Khabour

Abbas

et al. 2015

Drug and Chemical Toxicology

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In this study, several unsymmetrical Schiff bases and their cobalt and manganese complexes have been synthesized and characterized. The unsymmetrical Schiff bases were prepared from reaction of o-phenylendiamine derivatives with 1-hydroxy-2-acetonaphthone and then the product was reacted with the following aldehydes: salicyaldehyde, 2-hydroxynaphthaldehyde, 2-pyridinecarboxaldehyde and 2-qinolinecarboxaldehyde to produce the desired tetradentate unsymmetrical Schiff base ligands H2SL, H2NL, HPYL and HQN, respectively. Reaction of these ligands with cobalt and manganese salts produced complexes of the general formula [M(SL)], [(NL)], [M(PYL)] and [M(QL)]. All the complexes were characterized by elemental analysis, infrared spectroscopy, UV-visible spectroscopy, electrical conductivity and magnetic susceptibility measurements. The prepared complexes were examined for their anti-bacterial activity using gram-positive and gram-negative pathogens. The following complexes showed strong antibacterial activity against Staphylococcus aureus: MnSL1, MnSL2 and MnSL3. The genotoxic activity of four complexes, which are MnNL1, MnSL1, CoNL1 and CoSL1, were examined using 8-hydroxy-2-deoxy guanosine (8-OHdG) assay in cultured human blood lymphocytes. All examined complexes were found to be genotoxic at examined concentrations (0.1-100 µg/mL), but with variable magnitudes (p < 0.05). The levels of 8-OHdG induced by MnNL1 and MnSL1 were significantly higher than that induced by CoNL1 and CoSL1 ones. In general, the order of mutagenicity of the compounds is MnSL1 > MnNL1 > CoSL1 > CoNL1. In conclusion, some of the prepared complexes showed some biological activities that might be of interest for future research.

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Manganese in Health and Disease

Cited by 229 publications

References 231 publications

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis

Synthesis, characterization and biological activity of some unsymmetrical Schiff base transition metal complexes

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