Manganese in atherogenesis: Detection, origin, and a role

Lozhkin, Andrey; Biktagirov, Timur; Abdul’yanov, V. A.; Gorshkov, Oleg; Timonina, E. V.; Mamin, G. V.; Orlinskiĭ, S. B.; Silkin, N. I.; Чернов, В. М.; Khairullin, R. N.; Салахов, М. Х.; Ilinskaya, О. N.

doi:10.1134/s1990750811020090

Cited by 5 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For X-band at T = 298 K spin-lattice (longitudinal) relaxation In [29] it was proposed that the HAp components of the aorta organomineralic matrix could serve at least as markers for the diagnosis of the atherosclerotic plaque formation/rupture risks. Advantages of the increased resolution and sensitivity of the HF 80 EPR methods in comparison to the conventional X-band were applied to detect and quantify the tissues containing the carbonate radicals in nano-HAp inclusions for the early diagnosis, to investigate spectral and relaxation characteristics of the naturally existing manganese or intentionally incorporated lead ions and to 85 establish their locations in atherosclerotic plaque and nano-HAp structures [18,[30][31][32][33][34]. W-band FS-ESE detected EPR spectrum of the 20 nm sample at T = 50 K is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

et al. 2014

View full text Add to dashboard Cite

Synthesized by the wet chemical precipitation technique hydroxyapatite powders (HAp) with the sizes of the crystallites of (20-10 50) nm and 1 m were analyzed by multi-frequency (9 and 95 GHz) electron paramagnetic resonance (EPR) methods. It is shown that during the synthesis process nitrate anions from the reagents (by-products) could incorporate into the HAp structure. The relaxation times and EPR parameters of the axially symmetric NO 3 2paramagnetic centers detected after X-ray irradiation of the product at room temperature are measured with high accuracy. Assignments of the observed EPR spectra as compared with that given in literature are discussed. Analyses of electron-nuclear double resonance (ENDOR) data from 1 H and 31 P nuclei and ab-15 initio density functional theory (DFT) calculations allow suggesting that the paramagnetic centers and nitrate anions as the precursors of NO 3 2radicals preferably occupy PO 4 3site in the HAp structure. 65 110 Troullier-Martins pseudopotentials [27] with the plane-wave cutoff energy of 70 Ry.

show abstract

Section: Resultsmentioning

confidence: 99%

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

et al. 2014

View full text Add to dashboard Cite

show abstract

“…MnSOD was reported to reduce the oxLDL-induced apoptosis of macrophages [ 87 , 96 ], protect against endothelial dysfunction [ 97 , 98 ], and inhibit the oxidation of LDL by endothelial cells [ 9 ]. Furthermore, the association of decreased activity of MnSOD with atherogenesis has suggested that analysis of Mn content in the vascular wall matrix may be one of prospective methods for the diagnosis of early stages of atherosclerosis [ 99 ].…”

Section: Mn and Atherosclerosismentioning

confidence: 99%

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Yang

2018

Oxidative Medicine and Cellular Longevity

357

225

View full text Add to dashboard Cite

Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxication are associated with adverse metabolic and neuropsychiatric effects. Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus (T2MD), obesity, insulin resistance, atherosclerosis, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and hepatic steatosis, has increased dramatically. Previous studies have found that ROS generation, oxidative stress, and inflammation are critical for the pathogenesis of metabolic diseases. In addition, deficiency in dietary Mn as well as excessive Mn exposure could increase ROS generation and result in further oxidative stress. However, the relationship between Mn and metabolic diseases is not clear. In this review, we provide insights into the role Mn plays in the prevention and development of metabolic diseases.

show abstract

“…In papers of Lozhkin et al [29, 30], human aorta specimens obtained from autopsy of patients with atherosclerosis were investigated. A negative correlation between the concentration of manganese ions and degree of AP calcification was found.…”

Section: Discussionmentioning

confidence: 99%

“…Lozhkin et al speculated that the decrease in the manganese content with the increasing of AP calcification could be connected with the deficiency of mitochondrial Mn-SOD [29, 30]. However, now this assumption does not seem to be quite reasonable, because it is apparently not all of Mn 2+ in AP has intracellular localization being in the mitochondrial Mn-SOD.…”

Section: Discussionmentioning

confidence: 99%

Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries

Chelyshev

Gafurov

Ignatiev

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

The search for adequate markers of atherosclerotic plaque (AP) instability in the context of assessment of the ischemic stroke risk in patients with atherosclerosis of the carotid arteries as well as for solid physical and chemical factors that are connected with the AP stability is extremely important. We investigate the inner lining of the carotid artery specimens from the male patients with atherosclerosis (27 patients, 42–64 years old) obtained during carotid endarterectomy by using different analytical tools including ultrasound angiography, X-ray analysis, immunological, histochemical analyses, and high-field (3.4 T) pulse electron paramagnetic resonance (EPR) at 94 GHz. No correlation between the stable and unstable APs in the sense of the calcification is revealed. In all of the investigated samples, the EPR spectra of manganese, namely, Mn2+ ions, are registered. Spectral and relaxation characteristics of Mn2+ ions are close to those obtained for the synthetic (nano) hydroxyapatite species but differ from each other for stable and unstable APs. This demonstrates that AP stability could be specified by the molecular organization of their hydroxyapatite components. The origin of the obtained differences and the possibility of using EPR of Mn2+ as an AP stability marker are discussed.

show abstract

Manganese in atherogenesis: Detection, origin, and a role

Cited by 5 publications

References 30 publications

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

Nitrogen-containing species in the structure of the synthesized nano-hydroxyapatite

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Paramagnetic Manganese in the Atherosclerotic Plaque of Carotid Arteries

Contact Info

Product

Resources

About