Manganese(II)-doped zinc/germanium oxide nanoparticles as a viable fluorescent probe for visual and time-resolved fluorometric determination of ascorbic acid and its oxidase

Han, Xinyue; Chen, Zi‐Han; Fan, Qian-Xi; Li, Kang-Ni; Mu, Fang-Ya; Luo, Qingying; Jin, Zongwen; Shi, Guoyue; Zhang, Min

doi:10.1007/s00604-019-3580-9

Cited by 16 publications

(8 citation statements)

References 37 publications

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“…Fortunately, with the popularization of smartphones and various applications, individual‐centered healthcare has come true. Inspired by the successful application of real‐time/on‐site monitoring of environmental pollutants and biological molecular, [ 32 , 62 ] we succeeded in performing the optical supramolecular sensing of UA with a smartphone equipped with a color‐scanning feature.…”

Section: Resultsmentioning

confidence: 99%

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Zhang

Chai

et al. 2022

Advanced Science

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Characterized by an excessively increased uric acid (UA) level in serum, hyperuricemia induces gout and also poses a great threat to renal and cardiovascular systems. It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self-built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar-level, while simultaneously excluding fluorescein (Fl) from the GC5A•Fl complex in the "switch-on" mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital-centered to individual-centered testing, visual detection of UA is studied through a smartphone equipped with a color-scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family-centered healthcare style. A high-throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.

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Section: Resultsmentioning

confidence: 99%

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Zhang

Chai

et al. 2022

Advanced Science

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“…Ascorbic acid, as an important antioxidant biomarker for ocular inflammations, has also been studied for fluorescence detections. 108 , 109 However, the detection of ascorbic acid at POC platforms was conducted in aqueous humor instead of tear fluid with a high accuracy over than 80%. 108 The sensor was mainly developed for diagnostics of ocular globe injuries and glaucoma care.…”

Section: Fluorescence Sensing Technologiesmentioning

confidence: 99%

“…Future development of the build-up application of smartphones can also be enriched with different sections of a variety of ocular diseases, and it would be user-friendly for real-time POC monitoring. Ascorbic acid, as an important antioxidant biomarker for ocular inflammations, has also been studied for fluorescence detections. , However, the detection of ascorbic acid at POC platforms was conducted in aqueous humor instead of tear fluid with a high accuracy over than 80% . The sensor was mainly developed for diagnostics of ocular globe injuries and glaucoma care.…”

Section: Fluorescence Sensing Technologiesmentioning

confidence: 99%

Fluorescence Sensing Technologies for Ophthalmic Diagnosis

Shi

Jiang

et al. 2022

ACS Sens.

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Personalized and point-of-care (POC) diagnoses are critical for ocular physiology and disease diagnosis. Real-time monitoring and continuous sampling abilities of tear fluid and user-friendliness have become the key characteristics for the applied ophthalmic techniques. Fluorescence technologies, as one of the most popular methods that can fulfill the requirements of clinical ophthalmic applications for optical sensing, have been raised and applied for tear sensing and diagnostic platforms in recent decades. Wearable sensors in this case have been increasingly developed for ocular diagnosis. Contact lenses, as one of the commercialized and popular tools for ocular dysfunction, have been developed as a platform for fluorescence sensing in tears diagnostics and real-time monitoring. Numbers of biochemical analytes have been examined through developed fluorescent contact lens sensors, including pH values, electrolytes, glucose, and enzymes. These sensors have been proven for monitoring ocular conditions, enhancing and detecting medical treatments, and tracking efficiency of related ophthalmic surgeries at POC settings. This review summarizes the applied ophthalmic fluorescence sensing technologies in tears for ocular diagnosis and monitoring. In addition, the cooperation of fabricated fluorescent sensor with mobile phone readout devices for diagnosing ocular diseases with specific biomarkers continuously is also discussed. Further perspectives for the developments and applications of fluorescent ocular sensing and diagnosing technologies are also provided.

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“…Zhang et al reported manganese( ii )-doped zinc/germanium oxide nanoparticles as a viable fluorescent probe for the determination of AA and AA oxidase in biological fluids. 16 Persistent luminescence nanoparticles (PLNPs) are emerging photoluminescent materials that can store excitation energy and delay luminescence and can effectively eliminate autofluorescence interference in biosensing and bioimaging. 17 These properties offer promising applications for PLPNs in biosensing and bioimaging.…”

Section: Introductionmentioning

confidence: 99%

A target-induced inner-filter effect-based ratiometric sensing platform by fluorescence modulation of persistent luminescent nanoparticles and 2,3-diaminophenazine

Zhang

Yao

et al. 2022

New J. Chem.

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Manganese(II)-doped zinc/germanium oxide nanoparticles as a viable fluorescent probe for visual and time-resolved fluorometric determination of ascorbic acid and its oxidase

Cited by 16 publications

References 37 publications

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing

Fluorescence Sensing Technologies for Ophthalmic Diagnosis

A target-induced inner-filter effect-based ratiometric sensing platform by fluorescence modulation of persistent luminescent nanoparticles and 2,3-diaminophenazine

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