Manganese (II) complexes of tridentate ligands having NNN donors: Structure, DFT calculations, superoxide dismutase, DNA interaction, nuclease and protease activity studies

Rathi, Sweety; Maji, Ankur; Ghosh, Kaushik

doi:10.1016/j.ica.2018.09.081

Cited by 14 publications

(4 citation statements)

References 54 publications

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“…Superoxide anions were generated during xanthine oxidase-catalyzed oxidative hydroxylation of xanthine to uric acid. Then, superoxides reduced nitro-blue-tetrazolium chloride into purple tetrazole-blue-diformazan, which could be quantitatively detected by spectrophotometrically measuring the increasing absorbance at 560 nm . The inhibition of formazan formation increased rapidly with increasing concentration of MnNPs or SF@Rsg-Mn (0–30 μg/mL), demonstrating that SF@Rsg-Mn possessed SOD-mimicking activity for eliminating superoxides under physiological conditions (Figure i).…”

Section: Resultsmentioning

confidence: 95%

“…Then, superoxides reduced nitro-blue-tetrazolium chloride into purple tetrazole-blue-diformazan, which could be quantitatively detected by spectrophotometrically measuring the increasing absorbance at 560 nm. 36 The inhibition of formazan formation increased rapidly with increasing concentration of MnNPs or SF@Rsg-Mn (0−30 μg/mL), demonstrating that SF@Rsg-Mn possessed SOD-mimicking activity for eliminating superoxides under physiological conditions (Figure 1i). When the MnNP concentration was 20 μg/mL, SF@Rsg-Mn exhibited a slightly lower inhibition rate (83.6%) on formazan formation compared to MnNPs (93.1%).…”

Section: Resultsmentioning

confidence: 96%

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Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues

Ding

Chen

Tao

et al. 2021

ACS Biomater. Sci. Eng.

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Obesity is a primary risk factor for type 2 diabetes, cardiovascular diseases, cancer, and other chronic diseases. Current antiobesity medications need frequent administration and show limited efficacy with severe side effects. Herein, browning agent rosiglitazone (Rsg) and antioxidant manganese tetroxide nanoparticles (MnNPs, around 250 nm) are integrated into electrospun short fibers (SF@Rsg-Mn) with a 1.5 μm width and a 20 μm length. Upon injection into inguinal adipose tissues, SF@Rsg-Mn are well retained in the local depots to sustainably release Rsg in 30 days for adipose tissue browning, while MnNPs on the fiber surface continuously scavenge adipose reactive oxygen species (ROS) for an extended period of time. Synergistic inhibition of fat accumulation through ROS scavenging and white adipocyte browning has been demonstrated for the first time, and the optimal synergistic ratio of Rsg and MnNPs is determined to be 1/14 via combination index examination. SF@Rsg-Mn inhibit lipid accumulation through downregulation of adipogenic gene PPARγ while promoting energy expenditure through upregulation of brown-specific gene UCP1 and mitochondrial function gene COX7A1. In a diet-induced obesity mouse model, a single injection of SF@Rsg-Mn into inguinal adipose tissues has accomplished a synergistic effect on body weight loss, fat reduction, glucose, and lipid metabolic improvement while minimizing adverse effects on other tissues, thereby paving the way to efficacious, safe, and practical treatment of obesity.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 96%

Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues

Ding

Chen

Tao

et al. 2021

ACS Biomater. Sci. Eng.

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“…However, a comparatively very small number of manganese(II) complexes are investigated for DNA binding affinity and nuclease activity studies. [21][22][23] Sim-ilarly, zinc is also an important trace element and plays a significant role in maintaining overall human health throughout the whole lifespan. [24] It is the second most abundant trace metal found in the biological system and is found in many enzymes of living organisms.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, manganese complexes also exhibit important biological activities, such as DNA‐binding, albumin‐binding and antitumor activity. However, a comparatively very small number of manganese(II) complexes are investigated for DNA binding affinity and nuclease activity studies [21–23] . Similarly, zinc is also an important trace element and plays a significant role in maintaining overall human health throughout the whole lifespan [24] .…”

Section: Introductionmentioning

confidence: 99%

Cu(II), Mn(II) and Zn(II) Complexes of Anthracene‐Affixed Carboxylate‐Rich Tridentate Ligand: Synthesis, Structure, Spectroscopic Investigation and Their DNA Binding Profile

et al. 2022

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Anthracene-affixed carboxylate-rich tridentate ligand containing three new mononuclear complexes, [Cu(acpa)(H 2 O) 2 ]⋅H 2 O (1), [Mn(acpa)(H 2 O) 2 ] (2) and [Zn(acpa)(H 2 O) 2 ] (3) (H 2 acpa = 3-(anthracene-9-ylmethyl-carboxymethyl-amino)-propionic acid), have been synthesized and characterized by various analytical and spectral methods. In methanol, complexes 1-3 have been prepared by carrying out reaction of the ligand H 2 acpa with stoichiometric amounts of CuSO 4 ⋅ 5H 2 O, MnSO 4 ⋅H 2 O and ZnSO 4 ⋅ 7H 2 O respectively, in the presence of NaOH at ambient temperature. The X-ray crystal structure analysis reveals that complex 1 consists of a distorted square pyramidal copper center, coordinated to one acpa 2À ligand in a tridentate manner (N,O,O) and two exogenous water molecules. On the other hand, the molecular structures of complexes 2 and 3, optimized by DFT method indicate that their core arrangements around the metal centers are similar to that of 1. In solution, the coordination phenomena of Cu((II), Mn(II) and Zn(II) ions with the ligand H 2 acpa and the structural features of the complexes have been authenticated by UV-Vis and fluorescence titration experiments. The composition of the M II /acpa 2À complexes (M = Cu, Mn, Zn) in 1-3 has been observed to be 1 : 1, based on the UV-Vis/fluorescence titration results which are further supported by X-ray crystallography and DFT calculation. Complexes 1-3 are investigated for their binding affinity towards Calf Thymus (CT) DNA in solution at pH ∼ 7.5 by UV-Vis and fluorescence spectroscopic methods. From the electronic absorption spectral studies, it has been found that the DNA binding constants of 1-3 are (5.67 � 0.32) × 10 4 M À 1 , (2.35 � 0.26) × 10 4 M À 1 and (2.49 � 0.33) × 10 4 M À 1 , respectively, following the order 1 > 3 > 2. Measurements of viscosity of DNA in the absence and presence of the metal complexes suggest that all three complexes interact with DNA through partial intercalative mode.

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Efficient Organoruthenium Catalysts for α‐Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies

Maji

Singh

et al. 2020

ChemCatChem

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A new family of phosphine free organometallic ruthenium(II) catalysts (Ru1–Ru4) supported by bidentate NN Schiff base ligands (L1–L4 where L1=N,N‐dimethyl‐4‐((2‐phenyl‐2‐(pyridin‐2‐ylmethyl)hydrazineylidene)methyl) aniline, L2=N,N‐diethyl‐4‐((2‐phenyl‐2‐(pyridin‐2‐ylmethyl)hydrazineylidene)methyl)aniline, L3=N,N‐dimethyl‐4‐((2‐phenyl‐2‐(pyridin‐2‐yl)hydrazineylidene)methyl)‐ aniline and L4=N,N‐diethyl‐4‐((2‐phenyl‐2‐(pyridin‐2‐yl)hydrazineylidene)methyl) aniline) was prepared and characterized. These half‐sandwich complexes acted as catalysts for C−C bond formation and exhibited excellent performance in the dehydrogenative coupling of ketones and amides. In the synthesis of C–C bonds, alcohols were utilized as the alkylating agent. A broad range of substrates, including sterically hindered ketones and alcohols, were well tolerated under the optimized conditions (TON up to 47000 and TOF up to 11750 h−1). This ruthenium (II) catalysts were also active towards the dehydrogenative cyclization of o‐amino benzyl alcohol for the formation of quinolines derivatives. Various polysubstituted quinolines were synthesized in moderate to excellent yields (TON up to 71000 and TOF up to 11830 h−1). Control experiments were carried out and the ruthenium hydride intermediate was characterized to support the reaction mechanism and a probable reaction pathway of dehydrogenative coupling for the C−C bond formation has been proposed.

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Manganese (II) complexes of tridentate ligands having NNN donors: Structure, DFT calculations, superoxide dismutase, DNA interaction, nuclease and protease activity studies

Cited by 14 publications

References 54 publications

Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues

Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues

Cu(II), Mn(II) and Zn(II) Complexes of Anthracene‐Affixed Carboxylate‐Rich Tridentate Ligand: Synthesis, Structure, Spectroscopic Investigation and Their DNA Binding Profile

Efficient Organoruthenium Catalysts for α‐Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies

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