Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy

Abstract

The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.

Theranostic nanosensitizers for highly efficient MR/fluorescence imaging‐guided sonodynamic therapy of gliomas

“…27,[34][35][36][37] In our study, the r 1 value for DVDMS-Mn-LPs was about 4-fold higher than that of the clinical approved Magnevist due to increased local concentration of Mn 2+ and lowered molecular tumbling rate in those nanocarrier systems. [34][35][36][37] Given that the generation of ROS plays an important role in SDT of tumour treatment, the potential of DVDMS-Mn-LPs to generate ROS was determined using 2′, 7′-dichlorofluorescin diacetate as a typical probe. 23,8 The probe will be deacetylated by cellular esterases to non-fluorescent 2′,7′-Dichlorodihydrofluorescin (DCFH), which is rapidly oxidized to highly fluorescent 2′,7′-Dichlorodihydrofluorescein (DCF) by ROS.…”

“…The optical and T 1 relaxation properties of DVDMS‐Mn‐LPs hold promises for dual‐mode contrast agent for fluorescence and MR imaging of tumours (Figure ). In fact, abundant macromolecules and nanoparticles have been used as platforms for manganese loading, resulting in improved r 1 value of chelated Mn 2+ (generally between 5 and 30 per mmol/L per seconds) . In our study, the r 1 value for DVDMS‐Mn‐LPs was about 4‐fold higher than that of the clinical approved Magnevist due to increased local concentration of Mn 2+ and lowered molecular tumbling rate in those nanocarrier systems .…”

“…In fact, abundant macromolecules and nanoparticles have been used as platforms for manganese loading, resulting in improved r 1 value of chelated Mn 2+ (generally between 5 and 30 per mmol/L per seconds) . In our study, the r 1 value for DVDMS‐Mn‐LPs was about 4‐fold higher than that of the clinical approved Magnevist due to increased local concentration of Mn 2+ and lowered molecular tumbling rate in those nanocarrier systems . Given that the generation of ROS plays an important role in SDT of tumour treatment, the potential of DVDMS‐Mn‐LPs to generate ROS was determined using 2′, 7′‐dichlorofluorescin diacetate as a typical probe .…”

Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics

“…In addition to the already established arsenal of nanoradiotracers, numerous other nanomaterials have been engineered and explored for use in cancer theranostics in the past few years. For instance, chalcogenides, especially copper sulfide nanoparticles (CuS NPs) have gained significant attention from the research community as photothermal contrast agents and have been employed for several biomedical applications including PAT [273–275], PTT [276–278], and drug delivery [279]. Similar to many other nanoplatforms discussed in this article, CuS nanoparticles may be synthesized in different shapes and sizes; nanospheres, nanocages, nanoflowers, nanoplates, nanotubes, nanorods, and nanowires[280].…”

Functionalisation of Colloidal Transition Metal Sulphides Nanocrystals: A Fascinating and Challenging Playground for the Chemist

“…Crystals 2017, 7, 110 19 of 37 photothermal effect and photoaoustic activity [413]. In this case, no clear evidence regarding neither the actual chemical nature of the surface (CuS or either oxidized species) nor the chemical nature of the functionalisation was provided, and the authors only stated that "The powdery CuS@MPG NPs were quite stable and could be stored for several months without any obvious change" without reporting any experimental data in this regard, which makes the assessment difficult.…”