Manganese effects in the liver following subacute or subchronic manganese chloride exposure in rats

Huang, Peili; Chen, Chunxia; Wang, Hui; Li, Guojun; Jing, Huaiqi; Han, Ying; Liu, Na; Xiao, Yang; Yu, Qiuhong; Liu, Yuting; Wang, Pengwen; Shi, Zhixiong; Sun, Zhiwei

doi:10.1016/j.ecoenv.2010.08.011

Cited by 40 publications

(19 citation statements)

References 41 publications

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“…Chronic Mn exposure impaired glutamatergic function in the majority of regions of the brain, perturbed GABAergic activity in the basal ganglia, and altered behavior in mice [9]. Excess Mn also leads to rat liver injury [10]. Mn exposure can even cause reproductive toxicity.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Zhu

Teng³

et al. 2015

Biol Trace Elem Res

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Manganese (Mn) pollution can cause tissue and organ dysfunction and structural damage. The toxicity of Mn in poultry was reported, but inflammatory damage that Mn induced in the testicular tissue has not been reported. The aim of this study was to investigate the effect of Mn poisoning on NF-κB/iNOS-COX-2 signaling pathway in chicken testes. One hundred eighty Hyline male chickens at 7 days of age were fed either commercial diet or MnCl2-added commercial diet containing 600, 900, and 1800 mg/kg Mn for 30, 60, and 90 days, respectively. The messenger RNA (mRNA) expression of nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS), nitric oxide (NO) content, iNOS activity, and histopathology were examined in chicken testes. The results showed that excess Mn upregulated mRNA expression of NF-κB, COX-2, TNF-α, and iNOS, NO content, and iNOS activity at 60th and 90th day. Mn had a time-dependent effect on NF-κB and TNF-α mRNA expression. Mn had a dose- and time-dependent effect on NO content and iNOS activity. Mn exposure induced chicken testis histological changes in dose- and time-dependent manner. It indicated that Mn exposure resulted in inflammatory injury of chicken testis tissue through NF-κB/iNOS-COX-2 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Zhu

Teng³

et al. 2015

Biol Trace Elem Res

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“…When there are excess levels of Mn in the liver, iron levels are likely decreased. This result is in agreement with those by Huang et al [236] who reported a significant decrease in liver iron levels in rats after exposure to MnCl2 by intraperitoneal injection. Although intraperitoneal injection of Mn is a different route from drinking water exposure, injected Mn would be eliminated by the liver through the bile into the GI tract.…”

Section: Discussionsupporting

confidence: 83%

Effect of hemochromatosis on manganese neurotoxicity

Alsulimani¹

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ABSTRACT:Manganese (Mn) is an essential element for normal brain function, but excess levels of Mn in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. While Mn is known to share iron transporters for cellular uptake, deficiency in the Hfe (hemochromatosis), a cellular iron regulatory protein, affects the activities of iron transporters and impairs iron metabolism. Previously it was shown that Mn uptake into the brain is increased after intranasal exposure to Mn in Hfe-deficient mice, a mouse model of iron overload hereditary hemochromatosis. However, there is limited information about the effect of Hfe deficiency on Mn toxicity after exposure by other routes. Mn exposure is common through ingestion and inhalation in both environmental and occupational settings. Because Hfe deficiency alters iron transporters, and since Mn shares iron transporters, I hypothesize that Hfe deficiency increases Mn toxicity by modulating Mn uptake from the absorption site and deposition into the target organ for Mn toxicity which is the brain after gastric exposure in drinking water and pulmonary exposure to Mn particles. Specific aims are focused on the effect of Hfe deficiency on 1) the expression levels of metal transporters in the brain, gut and lung including alveolar macrophages, 2) levels of Mn, 3) Mn-associated neurobehavioral impairments, and 4) mechanisms of Mn neurotoxicity. This research will enhance the knowledge of Mn exposure and uptake in Hfe-related hemochromatosis, a prevalent iron disorder in the world.

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“…There was an insignificant decrease in hepato-somatic indices of treatment groups compared to control. This result contradicts similar researches by Zhang., et al [10], Haung., et al [11], and Chandel and Jain [12], who observed an increase in liver weight. Rats that received vitamin C alone showed a little increase as compared to control.…”

Section: Histological Observationsmentioning

confidence: 92%

“…Rats that received vitamin C alone showed a little increase as compared to control. In similar studies by Chandel and Jain [12], rats exposed Lebda., et al [27], Huang., et al [11] and Chandel and Jain [12].…”

Section: Histological Observationsmentioning

confidence: 96%

“…Although the brain is the primary target of manganese toxicity, many patients have been diagnosed with liver impairments involving micronodular cirrhosis, unconjugated hyperbilirubinemia and elevated transaminase. Hepatotoxicity of manganese have also been shown through several animal experimentation studies [10][11][12]. Considering the vital role of the liver in manganese metabolism, destruction of the liver exposes other organs to the destructive effects of excess manganese.…”

Section: Introductionmentioning

confidence: 98%

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Assessment of the Ameliorative Effect of Vitamin C on Manganese Induced Liver Damage in Female Albino Rats

Ekanem¹,

Udoh²,

Akpan³

et al. 2019

Act Scie Medic

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Manganese effects in the liver following subacute or subchronic manganese chloride exposure in rats

Cited by 40 publications

References 41 publications

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Toxicological Effect of Manganese on NF-κB/iNOS-COX-2 Signaling Pathway in Chicken Testes

Effect of hemochromatosis on manganese neurotoxicity

Assessment of the Ameliorative Effect of Vitamin C on Manganese Induced Liver Damage in Female Albino Rats

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