Manganese-doped biostimulatory nanoneedle for MRI-visual bispecific antibody gene delivery and immunosuppression reversal as a cancer immunotherapy strategy

Cai, Jiali; Jiang, Shuhan; Liao, Jingtong; Fan, Hongqi; Chen, Peng; Shi, Shenghong; Huang, Shengfeng; Chen, Guochuang; Xu, Jian; Wang, Zhi-Yong

doi:10.1016/j.cej.2023.142242

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…T 2 relaxation, also known as spin−spin relaxation, refers to the process by which the magnetic spins of protons in a magnetic field lose their coherence after being disturbed. 47,48 These produced oxygen radicals, with unpaired electrons in their molecular orbitals, form small magnetic poles and affect the proton relaxation process in the microenvironment, leading to changes in the magnetic resonance signal value, which is similar to a previous report. 49 From the results, the r 2 value change of C-FeO@Mn is the largest during the catalytic reaction (Δr 2 = 100.4 mM −1 S −1 ).…”

Section: ■ Results and Discussionsupporting

confidence: 88%

Lanthanide-Assisted Nanozyme Performs Optical and Magnetic Resonance Dual-Modality Logical Signal for In Vitro Diagnosis

Shen,

Wang,

Bai

et al. 2024

Anal. Chem.

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The iron nanozyme-based colorimetric method, which is widely applied for biosubstrate detection in in vitro diagnosis (IVD), faces some limitations. The optimal catalytic conditions of iron nanozymes necessitate a strong acidic environment, high temperature, and other restrictive factors; additionally, the colorimetric results are highly influenced by optical interferences. To address these challenges, iron nanozymes doped with various transition elements were efficiently prepared in this study, and notably, the manganese-modified one displayed a high catalytic activity owing to its electron transfer property. Furthermore, the introduction of lanthanide ions into the catalytic reactions, specifically the neodymium ion, significantly boosted the generation efficiency of hydroxyl radicals; importantly, this enhancement extended to a wide range of pH levels and temperatures, amplifying the detection signal. Moreover, the nanozyme's superparamagnetic characteristic was also employed to perform a logical optical and magnetic resonance dual-modality detection for substrates, effectively eliminating background optical interference and ensuring a reliable verification of the signal's authenticity. Based on this magnetic signal, the integration of natural glucose oxidase with the nanozyme resulted in a notable 61.5% increase in detection sensitivity, surpassing the capabilities of the traditional colorimetric approach. Consequently, the incorporation of lanthanide ions into the magnetic nanozyme enables the effective identification of physiological biomarkers through the dual-modality signal. This not only guarantees enhanced sensitivity but also demonstrates significant potential for future applications.

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Section: ■ Results and Discussionsupporting

confidence: 88%

Lanthanide-Assisted Nanozyme Performs Optical and Magnetic Resonance Dual-Modality Logical Signal for In Vitro Diagnosis

Shen,

Wang,

Bai

et al. 2024

Anal. Chem.

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“…Manganese oxide-based nanomaterials have been observed as tumor microenvironment (TME)-responsive biomaterials and exhibit significant potential for immunotherapy due to their ability to strongly trigger anti-tumor immune responses in various ways. [201][202][203] Mn-Based NSs are found to be an immunomodulator and act as potential immunotherapeutic agents in cancer treatment. These inorganic NSs induce cytokine production through the cGAS/STING pathway and ICD, and they can promote immunotherapy through a variety of mechanisms, including oxygen-enhanced immunogenic PDT.…”

Section: Cancer Immunotherapymentioning

confidence: 99%

Design of manganese-based nanomaterials for pharmaceutical and biomedical applications

Jain,

Jangid,

Pooja

et al. 2024

J. Mater. Chem. B

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“…Mn-based oxides, chelates, and coordination complexes are used as dopants to alter the relaxation times for the improved signal intensity resulting in better image contrast. Cai et al [158] reported Mn doped silica materials of different dimensions for the MRI visualization. Mn-doped Fe 3 O 4 is found to be a strong candidate for resonance imaging techniques; Mn doping decreases the hydrodynamic size and increases the saturation magnetization and magnetic moments resulting in higher r 2 and r 1 due to tenacious spin-spin interactions [159].…”

Section: Medical Applicationsmentioning

confidence: 99%

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

Manavalan,

Enoch,

Volegov

et al. 2024

Journal of Nanomaterials

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Apart from our imagination, the nanotechnology industry is rapidly growing and promises that the substantial changes that will have significant economic and scientific impacts be applicable to a wide range of areas, such as aerospace engineering, nanoelectronics, environmental remediation, and medical healthcare. In the medical field, magnetic materials play vital roles such as magnetic resonance imaging (MRI), hyperthermia, and magnetic drug delivery. Among them, manganese oxide garnered great interest in biomedical applications due to its different oxidation states (Mn2+, Mn3+, and Mn4+). Manganese oxide nanostructures are widely explored for medical applications due to their availability, diverse morphologies, and tunable magnetic properties. In this review, cogent contributions of manganese oxides in medical applications are summarized. The crystalline structure and oxidation states of Mn oxides are highlighted. The synthesis approaches of Mn-based nanoparticles are outlined. The important medical applications of manganese-based nanoparticles like magnetic hyperthermia, MRI, and drug delivery are summarized. This review is conducted to cover the future impact of MnOx in diagnostic and therapeutic applications.

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Manganese-doped biostimulatory nanoneedle for MRI-visual bispecific antibody gene delivery and immunosuppression reversal as a cancer immunotherapy strategy

Cited by 4 publications

References 56 publications

Lanthanide-Assisted Nanozyme Performs Optical and Magnetic Resonance Dual-Modality Logical Signal for In Vitro Diagnosis

Lanthanide-Assisted Nanozyme Performs Optical and Magnetic Resonance Dual-Modality Logical Signal for In Vitro Diagnosis

Design of manganese-based nanomaterials for pharmaceutical and biomedical applications

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

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