Manganese deficiency and toxicity: Are high or low dietary amounts of manganese cause for concern?

Finley, John W.; Davis, Cindy D.

doi:10.1002/biof.5520100102

Cited by 127 publications

(87 citation statements)

References 83 publications

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“…Results also indicate higher toxicity in diets with more vegetable-based products and less meat. Accordingly, Finley and Davis [57] discuss the potential toxicity of vegetarian diets due to increased manganese intake. Gibson [58] associate increased levels of Mg, in addition to selenium and copper, from increased intake of cereals.…”

Section: Reducing Meat Consumptionmentioning

confidence: 99%

Evaluating the Environmental Consequences of Swedish Food Consumption and Dietary Choices

Martin

Brandão

2017

Sustainability

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Abstract:In recent years, a growing interest from consumers to know the origins and contents of foods has put alternative choices, such as organic foods and dietary changes, on the agenda. Dietary choices are important to address, as many studies find that activities related to food production account for nearly 20-30% of anthropogenic greenhouse gas (GHG) emissions. Nonetheless, while GHG emissions are important, often other environmental impact categories are not considered in the assessment of the sustainability of different foods, diets and choices. This study aims to quantify the implications of dietary choices for Swedish food consumption on a broad range of environmental impact categories using life cycle assessment to provide insight into the impacts, and potential tradeoffs, associated with certain food products and dietary choices. Scenarios are used to assess the implications of diets with reduced meat, increased Swedish food consumption, increased organic foods, vegan and semi-vegetarian diets. The results indicate that tradeoffs could be possible with certain dietary choices. Increasing Swedish food production and consumption may lead to lower impacts for all impact categories by reducing imports, although limitations in growing season and availability of foods in Sweden allows only for minor increases. The results also indicate that large reductions of greenhouse gas emissions are possible by reducing meat consumption, i.e., by halving meat consumption and through vegan and vegetarian diets. Nonetheless, an increase in vegetable, legume and fruit products may lead to a potential increase in human and ecosystem toxicity. Diets based on nutritional guidelines, show reductions in all impact categories, as these guidelines call for an increase in vegetables and fruits and a reduction in meat consumption. An increase in organic foods showed no significant change in climate impact, although toxicity potential was reduced significantly. Increasing consumption of organic foods may also lead to a reduction in biodiversity damage potential, and if all food is produced organically, it risks increasing eutrophication and land use.

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Section: Reducing Meat Consumptionmentioning

confidence: 99%

Evaluating the Environmental Consequences of Swedish Food Consumption and Dietary Choices

Martin

Brandão

2017

Sustainability

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“…Adult dietary intake of Mn is estimated to be between 0.9 to 10 mg Mn/day (ATSDR, 2000;Finley and Davis, 1999). Based on the Total Diet Study, grains, beverages (tea), and vegetables provide approximately 33, 20, and 18% of dietary Mn in adult males, respectively (Pennington and Young, 1991).…”

Section: Modes Of Manganese Exposure Diet and Watermentioning

confidence: 99%

Manganese neurotoxicity: A focus on the neonate

Erikson

Thompson

Aschner

et al. 2007

Pharmacology & Therapeutics

221

141

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Manganese (Mn) is an essential trace metal found in all tissues, and it is required for normal amino acid, lipid, protein, and carbohydrate metabolism. While Mn deficiency is extremely rare in humans, toxicity due to overexposure of Mn is more prevalent. The brain appears to be especially vulnerable. Mn neurotoxicity is most commonly associated with occupational exposure to aerosols or dusts that contain extremely high levels (> 1-5 mg Mn/m 3 ) of Mn, consumption of contaminated well water, or parenteral nutrition therapy in patients with liver disease or immature hepatic functioning such as the neonate. This review will focus primarily on the neurotoxicity of Mn in the neonate. We will discuss putative transporters of the metal in the neonatal brain and then focus on the implications of high Mn exposure to the neonate focusing on typical exposure modes (e.g., dietary and parenteral). Although Mn exposure via parenteral nutrition is uncommon in adults, in premature infants, it is more prevalent, so this mode of exposure becomes salient in this population. We will briefly review some of the mechanisms of Mn neurotoxicity and conclude with a discussion of ripe areas for research in this underreported area of neurotoxicity.

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“…Mn is a trace element that is related to the transport and absorption of Fe, and the levels of these two elements exhibit a positive correlation [22] . Mn also plays a significant role in the immune system, interacting with neutrophils and macrophages and protecting the body against oxidative stress [23] .…”

mentioning

confidence: 99%

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Bozan¹,

Dinç²,

Demır³

et al. 2017

Int Adv Otol

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OBJECTIVE:To determine the serum iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), and lead (Pb) levels in patients with chronic otitis media (COM) and to evaluate the association of the serum levels of these elements with treatment outcomes. MATERIALS and METHODS:Thirty-one healthy volunteers and 31 patients with COM were prospectively included in this study. Serum levels of Fe, Zn, Mn, Mg, Cu, Co, and Pb were determined by an atomic absorption UNICAM-929 spectrophotometer.RESULTS: Serum Co, Pb, and Fe levels were significantly increased (p<0.001) and serum Cu, Zn, Mg, and Mn levels were significantly reduced in patients with COM compared with controls (p<0.001). Serum Co and Mn levels were significantly decreased (p<0.001 and p<0.005, respectively) and serum Cu levels were significantly increased after surgery (p<0.005). The other evaluated blood chemicals and heavy metals did not exhibit significant differences (p>0.05). CONCLUSION:Significant alterations in the serum chemical composition of patients with COM were observed. Moreover, with surgical treatment, serum levels of some of these chemicals were significantly altered. Further prospective studies are warranted to elucidate the exact association of these alterations in the etiopathogenesis of COM.

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Manganese deficiency and toxicity: Are high or low dietary amounts of manganese cause for concern?

Cited by 127 publications

References 83 publications

Evaluating the Environmental Consequences of Swedish Food Consumption and Dietary Choices

Evaluating the Environmental Consequences of Swedish Food Consumption and Dietary Choices

Manganese neurotoxicity: A focus on the neonate

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

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