Manganese-Based Carbon Monoxide-Releasing Molecules: A Multitude of Organometallic Pharmaceutical Candidates Primed for Further Biological Analysis

Ward, Jonathan S.

doi:10.1016/b978-0-12-820206-7.00047-0

Cited by 2 publications

(1 citation statement)

References 73 publications

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“…A notable class of light-activated ligand-releasing compounds is carbon monoxide releasing molecules (CORMs) 245 , which are effective at killing bacteria upon CO release. Both metal-based 176,184,[246][247][248][249][250][251] and organic 252,253 antimicrobial CORMs have been reported. For example, tricarbonylchloro(glycinato)ruthenium(II) (CORM-3) inhibited the in vitro growth of P. aeruginosa at concentrations as low as 0.5 µM, displayed no cytotoxicity at 200 µM and increased the survival of mice to 100% in a P. aeruginosa peritonitis model 72 h after infection at 7.5 mg kg −1 (ref.…”

Section: Photoactivated Metal Complexesmentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.

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