Abstract:Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early as 1837. Despite extensive study over the past century, it is only now becoming clear that Mn neurotoxicity involves complex pathophysiological signaling mechanisms between neurons and glial cells. Glial cells are an important target of Mn in the brain, where high levels of the metal accumulate, activating inflammatory signaling pathways that damage neurons through overproduction of numerous reactive oxygen and nitrogen speci… Show more
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