“…Interestingly, Mn-ions were found to protect against the Shiga toxin in mice by redirecting it to the degradative pathway [161,162], but no protection was provided against Stx2 under the same conditions [163]. Also, protection against Shiga toxins may depend on cell type and the mouse strain [164], and caution should be exerted since Mn-ions are neurotoxic [164,165]. Quite recently, chemical compound screens have provided us with drugs that seem to inhibit endosome-to-Golgi transport and that protect against both the plant toxin ricin and Shiga toxin [166][167][168].…”