Manganese air exposure assessment and biological monitoring in the manganese alloy production industry

Ellingsen, Dag G.; Hetland, Siri; Thomassen, Yngvar

doi:10.1039/b209095c

Cited by 63 publications

(51 citation statements)

References 22 publications

(34 reference statements)

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“…The obtained results have shown the high pollution of airborne manganese particles in the studied workplace and it is slightly close to the finding that was reported by Ellingsen et al, revealing the respirable manganese concentration that was 254 μg/m 3 and it assessed within 3 days for 100 of exposed workers [29]. This result is slightly lower than the result that was obtained in the same research [21]; the variety of blood serum samples was the same (N = 100) as in that study: the samples analysis by means of the atomic absorption method showed that the level of manganese in blood's serum was equal to the air pollutants' concentrations.…”

Section: Discussionsupporting

confidence: 90%

Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Mirmohammadi¹,

Moghaddasi²,

Yazdani³

et al. 2017

Med Pr

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Background: Manganese (Mn) used as raw material for melting process in the ferrous foundry is considered as hazardous neurotoxic substance because it accumulates in the central nervous system and may cause neurological disorders. The furnace-men and melting department workers are potentially exposed to manganese particles or fume in the workplace. The objective of the research has been to investigate the sources and levels of manganese exposure in the foundry by correlation of blood-manganese (B-Mn) and air-manganese (air-Mn) measurement. Material and Methods: Air-Mn and Mn of blood serum were measured involving workers who worked in a big-sized foundry during 1 year. The standard method of the Occupational Safety and Health Administration (OSHA) ID-121 was used for air and blood assessment and atomic absorption spectroscopy (AAS) was carried out for air and blood sample analysis. Results: The air sampling results have revealed that there is a high exposure to manganese (4.5 mg/m 3 ) in the workplace as compared to the National Institute for Occupational Safety and Health's (NIOSH) time weighted average (the reference time-weighted average (TWA) = 1 mg/m 3 ). The average blood serum Mn concentration was 2.745 μg/l for subjects working for shorter than 3 months and 274.85 μg/l for subjects working 3-12 months. Conclusions: Against the research hypothesis there was no correlation between the air-Mn concentration and the B-Mn (serum) level of manganese in the serum of the exposed subjects. It may be due to short time of air sampling of manganese airborne particles, and a real-time monitoring of airborne manganese particles is suggested for any future study. Med Pr 2017;68(4): [449][450][451][452][453][454][455][456][457][458]

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Section: Discussionsupporting

confidence: 90%

Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Mirmohammadi¹,

Moghaddasi²,

Yazdani³

et al. 2017

Med Pr

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“…This could suggest that the bioavailability of SiMn is low, because the only difference between 'inhalable Mn' and 'soluble inhalable Mn' is the exclusion of SiMn in the latter marker of exposure. This association has previously not been shown, and should be elucidated further owing to the possible practical consequences (Ellingsen et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

“…A four-step chemical fractionation procedure was applied for the speciation of Mn in a selection of the collected air filters (Thomassen et al, 2001;Ellingsen et al, 2003 (2003) and 'insoluble' Mn digested in aqua regia/hydrofluoric acid (SiMn) (components 4). A total of 199 samples of the inhalable aerosol fraction (in 97 subjects) and 150 respirable aerosol samples (in 53 subjects) were speciated.…”

Section: Air Exposure Assessmentmentioning

confidence: 99%

Iron status in manganese alloy production workers

Ellingsen

Haug

Ulvik

et al. 2003

J of Applied Toxicology

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The aim of this study was to investigate markers of iron status in production workers with current and long-term exposure to manganese (Mn) alloys. A total of 100 Mn-exposed male workers were compared with 100 male controls matched for age in a cross-sectional study. The geometric mean urinary Mn concentration in the exposed workers was 0.9 nmol mmol(-1) creatinine (range = 0.1-126.3), compared with 0.4 nmol mmol(-1) creatinine (range = 0.1-13.1) in the controls. The index group had been exposed to Mn for 20 years on average (range = 2.1-41.0). The geometric mean concentration of soluble transferrin receptor was lower in the exposed subjects than in the controls (2.2 vs 2.6 mg l(-1); P < 0.001) and the concentration was negatively associated with current exposure to "soluble" Mn in the inhalable aerosol fraction and with current smoking habits. An association was found between the concentration of serum soluble transferrin receptor and the concentration of Mn in whole blood (Pearson's r = 0.48; P < 0.001) in the controls. The results suggest that Mn-exposed workers have higher intracellular iron concentration in the erythrocyte precursors than the controls, resulting in a down-regulation of transferrin receptors on the surface of these cells. The concentrations of Mn in the blood of occupationally non-exposed individuals appear to be influenced by iron status, even at physiological iron levels.

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“…The corresponding geometric mean concentration of "inhalable manganese" is 1270 (range 386-11 457) µg/m 3 (95% CI 944-1711). Between 10% and 11% of the manganese was found in the respirable aerosol fraction (18). These estimates do not consider the impact of exposure duration on the measured serum prolactin concentrations.…”

Section: Discussionmentioning

confidence: 97%

“…All the dose estimates were based on individually collected samples, and they represent the mean value of the available samples for each subject (generally two or three samples for each subject). Extensive details on sampling, speciation, and day-to-day variations in exposure have been presented elsewhere (18,19).…”

Section: Exposure Assessmentmentioning

confidence: 99%