Manganese-52m for direct application: A new 52Fe/52mMn generator based on a hydroxamate resin

Herscheid, J. D. M.; Vos, Cornelis M.; Hoekstra, A.

doi:10.1016/0020-708x(83)90147-3

Cited by 18 publications

(7 citation statements)

References 8 publications

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“…Several groups have designed and built automated systems for 89 Zr [12, 13]. For example Wooten et al [14] reported a custom-made system to safely and routinely produce 89 Zr with high radionuclidic purity (>99.99%) and satisfactory effective specific activity (5–353 mCi ·μ mol −1 (0.01%–0.88% of theoretical specific activity)) based on previous developments in separation and purification techniques [9–11, 15]. …”

Section: Production Of 89zrmentioning

confidence: 99%

Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients

Watering

Rijpkema

Perk

et al. 2014

BioMed Research International

111

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Antibody based positron emission tomography (immuno-PET) imaging is of increasing importance to visualize and characterize tumor lesions. Additionally, it can be used to identify patients who may benefit from a particular therapy and monitor the therapy outcome. In recent years the field is focused on 89Zr, a radiometal with near ideal physical and chemical properties for immuno-PET. In this review we will discuss the production of 89Zr, the bioconjugation strategies, and applications in (pre-)clinical studies of 89Zr-based immuno-PET in oncology. To date, 89Zr-based PET imaging has been investigated in a wide variety of cancer-related targets. Moreover, clinical studies have shown the feasibility for 89Zr-based immuno-PET to predict and monitor treatment, which could be used to tailor treatment for the individual patient. Further research should be directed towards the development of standardized and robust conjugation methods and improved chelators to minimize the amount of released Zr4+ from the antibodies. Additionally, further validation of the imaging method is required. The ongoing development of new 89Zr-labeled antibodies directed against novel tumor targets is expected to expand applications of 89Zr-labeled immuno-PET to a valuable method in the medical imaging.

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Section: Production Of 89zrmentioning

confidence: 99%

Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients

Watering

Rijpkema

Perk

et al. 2014

BioMed Research International

111

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“…Hersheid et al (1983) report original synthesis of the resin for use in a 52 Fe/ 52m Mn generator [17]. Figure 3 depicts the chemical mechanism as described in [7].…”

Section: Separation Chemistrymentioning

confidence: 99%

89Zr Radiochemistry for Positron Emission Tomography

Severin¹,

Engle²,

Barnhart³

et al. 2011

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“…1 89 Zr can be produced on a biomedical cyclotron from a yttrium (Y) target via the 89 Y(p,n) 89 Zr reaction. While 89 Zr can be separated from the target material by anion exchange chromatography, 2 Meijs et al 3 achieved improved recovery and radionuclidic purity using a hydroxamate resin that Herscheid et al 4 had previously used for the purification of a different radionuclide. More recently, Holland et al 1 standardized the overall process for 89 Zr production using a hydroxamate resin column.…”

Section: Introductionmentioning

confidence: 99%