Manganese

Lucchini, Roberto; Aschner, Michael; kim, Yangho; Šarić, Marko

doi:10.1016/b978-0-444-59453-2.00045-7

Cited by 23 publications

(16 citation statements)

References 347 publications

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“…Metals with neurotoxic properties such as Mn ions [30] have been assigned a pathogenic role in various neurodegenerative disorders [31,32]. Nerve cells of the brain are in equilibrium with the extracellular space and with the cerebrospinal fluid (CSF).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

Wallin

Kulkarni

Abelein

et al. 2016

Journal of Trace Elements in Medicine and Biology

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Growing evidence links neurodegenerative diseases to metal exposure. Aberrant metal ion concentrations have been noted in Alzheimer's disease (AD) brains, yet the role of metals in AD pathogenesis remains unresolved. A major factor in AD pathogenesis is considered to be aggregation of and amyloid formation by amyloid-β (Aβ) peptides. Previous studies have shown that Aβ displays specific binding to Cu(II) and Zn(II) ions, and such binding has been shown to modulate Aβ aggregation. Here, we use nuclear magnetic resonance (NMR) spectroscopy to show that Mn(II) ions also bind to the N-terminal part of the Aβ(1-40) peptide, with a weak binding affinity in the milli- to micromolar range. Circular dichroism (CD) spectroscopy, solid state atomic force microscopy (AFM), fluorescence spectroscopy, and molecular modeling suggest that the weak binding of Mn(II) to Aβ may not have a large effect on the peptide's aggregation into amyloid fibrils. However, identification of an additional metal ion displaying Aβ binding reveals more complex AD metal chemistry than has been previously considered in the literature.

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Section: Introductionmentioning

confidence: 99%

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

Wallin

Kulkarni

Abelein

et al. 2016

Journal of Trace Elements in Medicine and Biology

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“…Manganese (Mn), one of the more abundant metals on Earth, acts as an essential cofactor of multiple enzymes. Mn occurs naturally in most foods and Mn deficiency in humans is therefore rare; however, elevated levels of Mn can occur due to a rare inherited genetic disorder (hypermanganesemia) or as a consequence of environmental Mn exposure ( Lucchini et al. , 2015 ).…”

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confidence: 99%

“…Physiological Mn levels are regulated by homeostatic mechanisms. Epithelial cells in the intestine or lungs take up Mn, which enters the blood circulation; from there, it can cross the blood-brain barrier ( Lucchini et al. , 2015 ).…”

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confidence: 99%

Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function

et al. 2015

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Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes an Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn concentrations by ICP-MS or atomic absorption spectroscopy and genotyped 2 SLC30A10 non-coding SNPs (rs2275707 and rs12064812) by TaqMan PCR in cohorts from Bangladesh (N = 406), the Argentinean Andes (N = 198), and Italy (N = 238). We also measured SLC30A10 expression in whole blood by TaqMan PCR in a sub-group (N = 101) from the Andean cohort, and neurological parameters (sway velocity and finger-tapping speed) in the Italian cohort. The rs2275707 variant allele was associated with increased Mn concentrations in the Andes (8%, P = .027) and Italy (10.6%, P = .012), but not as clear in Bangladesh (3.4%, P = .21; linear regression analysis adjusted for age, gender, and plasma ferritin). This allele was also associated with increased sway velocity (15%, P = .033; adjusted for age and sex) and reduced SLC30A10 expression (−24.6%, P = .029). In contrast, the rs12064812 variant homozygous genotype was associated with reduced Mn concentrations, particularly in the Italian cohort (−18.4%, P = .04), and increased finger-tapping speed (8.7%, P = .025). We show that common SNPs in SLC30A10 are associated with blood Mn concentrations in 3 unrelated cohorts and that their influence may be mediated by altered SLC30A10 expression. Moreover, the SNPs appeared to influence neurological functions independent of blood Mn concentrations, suggesting that SLC30A10 could regulate brain Mn levels.

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“…Primary manifestations of manganese deficiency in livestock are impaired growth, skeletal abnormalities, depressed reproductive function, ataxia of the newborn and faults in lipid and carbohydrate metabolism (Suttle, 2010). ATSDR (2012) and, more recently, Lucchini et al (2015) reviewed the absorption, distribution, metabolism and excretion (ADME) and toxicity of manganese.…”

Section: Additional Informationmentioning

confidence: 99%

“…ATSDR () and, more recently, Lucchini et al. () reviewed the absorption, distribution, metabolism and excretion (ADME) and toxicity of manganese.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of manganese hydroxychloride as feed additive for all animal species

2016

EFS2

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The additive under assessment, manganese hydroxychloride, contains ≥ 45% manganese (Mn). Manganese hydroxychloride is a safe source of manganese for all target species when used up to the maximum level of total manganese in complete feed authorised in the EU (Fish 100 (total) and Other species 150 (total) mg Mn/kg feedingstuffs). Manganese hydroxychloride would substitute for other manganese sources in feed. It does not differently affect tissue deposition compared to manganese sulphate. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that the use of manganese hydroxychloride in animal nutrition is safe for the consumers, provided the maximum authorised manganese content in complete feed is respected. In the absence of specific data, the FEEDAP Panel cannot conclude on the safety for the user when handling the additive. The use of manganese hydroxychloride in animal nutrition for all animal species is not expected to pose a risk to the environment. Manganese hydroxychloride is considered a source of bioavailable manganese as indicated by a dose-dependent increase of manganese deposition in bone and liver based on two studies on chickens for fattening. The FEEDAP Panel concludes that the additive is efficacious in meeting the manganese requirements for all animal species/categories.

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Manganese

Cited by 23 publications

References 347 publications

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function

Safety and efficacy of manganese hydroxychloride as feed additive for all animal species

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