Mangaba (Hancornia speciosa Gomes) fruit juice decreases acute pulmonary edema induced by Tityus serrulatus venom: Potential application for auxiliary treatment of scorpion stings

Yamashita, Fabiana De Oliveira; Torres-Rêgo, Manoela; Gomes, Jacyra Antunes dos Santos; Félix-Silva, Juliana; Ferreira, Leandro de Santis; Silva-Júnior, Arnóbio Antônio da; Zucolotto, Silvana Maria; Fernandes-Pedrosa, Matheus de Freitas

doi:10.1016/j.toxicon.2020.02.025

Cited by 17 publications

(13 citation statements)

References 60 publications

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“… Ref. : references - leaves n = 8 [ 17 , 36 , 37 , 60 , 72 , 74 , 111 , 112 ]; fruit n = 20 [ 5 , 6 , [38] , [39] , [40] , [41] , 46 , 47 , 50 , [55] , [56] , [57] , 7 , 8 , 19 , 22 , 24 , 26 , 35 , 37 ]; tree bark n = 1 [ 108 ]; tree latex n = 1 [ 109 ]. AA: Ascorbic acid.…”

Section: Characterization Of the Hancornia Speciosamentioning

confidence: 99%

“…Studies have shown that the plant is a source of several nutrients and bioactive compounds, especially the phytochemicals rutin and chlorogenic acid [ 5 , 6 , 7 , 8 ]. In addition, recently, has been discovered that the different parts of the mangabeira tree (leaf, fruit pulp, latex, and bark) presents pharmacological benefits on common health conditions, such as hypertension [ 9 , 10 , 11 ], diabetes [ 12 ], and inflammation [ 5 , 8 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biotechnological potential of Hancornia speciosa whole tree: A narrative review from composition to health applicability

Reis

Rodrigues

Filho

et al. 2022

Heliyon

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Section: Characterization Of the Hancornia Speciosamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biotechnological potential of Hancornia speciosa whole tree: A narrative review from composition to health applicability

Reis

Rodrigues

Filho

et al. 2022

Heliyon

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“…Subsequently, 200 µL Bradford reagent was added and a plate was prepared for 1 min. After 30 min incubation at room temperature (25 • C), the microplate reader (Epoch, BioTek) was read at a wavelength of 595 nm [71,72]. The supernatant exudates from the air pouch were also used to measure cytokine levels (TNF-α, IL-1β, and IL-6).…”

Section: Zymosan-induced Air Pouch Modelmentioning

confidence: 99%

Production and Characterization of Chitooligosaccharides: Evaluation of Acute Toxicity, Healing, and Anti-Inflammatory Actions

Andrade

Araújo

Torres-Rêgo

et al. 2021

IJMS

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The search for promising biomolecules such as chitooligosaccharides (COS) has increased due to the need for healing products that act efficiently, avoiding complications resulting from exacerbated inflammation. Therefore, this study aimed to produce COS in two stages of hydrolysis using chitosanases derived from Bacillus toyonensis. Additionally, this study aimed to structurally characterize the COS via mass spectrometry, to analyze their biocompatibility in acute toxicity models in vivo, to evaluate their healing action in a cell migration model in vitro, to analyze the anti-inflammatory activity in in vivo models of xylol-induced ear edema and zymosan-induced air pouch, and to assess the wound repair action in vivo. The structural characterization process pointed out the presence of hexamers. The in vitro and in vivo biocompatibility of COS was reaffirmed. The COS stimulated the fibroblast migration. In the in vivo inflammatory assays, COS showed an antiedematogenic response and significant reductions in leukocyte migration, cytokine release, and protein exudate. The COS healing effect in vivo was confirmed by the significant wound reduction after seven days of the experiment. These results indicated that the presence of hexamers influences the COS biological properties, which have potential uses in the pharmaceutical field due to their healing and anti-inflammatory action.

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“…Furthermore, a recent study demonstrated that fruit juice from H. speciosa inhibited the inflammatory effects of acute pulmonary edema and kidney damage induced by T. serrulatus envenomation. This anti‐inflammatory potential was attributed, at least in part, to the presence of phenolic derivatives identified in the fruit juice, which can actuate in synergism for the development of this activity (Yamashita et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…This anti-inflammatory potential was attributed, at least in part, to the presence of phenolic derivatives identified in the fruit juice, which can actuate in synergism for the development of this activity (Yamashita et al, 2020).…”

mentioning

confidence: 99%

Impact of processing, packages, and storage on quality of mangaba ( Hancornia speciosa Gomes) jelly

Zitha

Machado

Junqueira

et al. 2020

J. Food Process. Preserv.

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Brazil, due to its continental geographic dimensions, has the largest biodiversity in the world. The Brazilian Savannah, well known as "Cerrado," is the second-largest biome in South America (the largest biome is the Amazon rainforest) and it covered, on 2002, approximately 23% of the country's surface area, or 2 million km 2 (Lahsen, Bustamante, & Dalla-Nora, 2016). The Cerrado biome presents a huge variety of native species, whose exotic fruit has great potential because of their functional properties and nutritional value, as well as their pleasant and even exotic sensory traits, such as color, flavor, and aroma (Almeida et al., 2019; Silva et al., 2015). These fruits, which are little explored scientifically and commercially, represent potential interest to the agribusiness, possible future source of income for the local population and an opportunity

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Mangaba (Hancornia speciosa Gomes) fruit juice decreases acute pulmonary edema induced by Tityus serrulatus venom: Potential application for auxiliary treatment of scorpion stings

Cited by 17 publications

References 60 publications

Biotechnological potential of Hancornia speciosa whole tree: A narrative review from composition to health applicability

Biotechnological potential of Hancornia speciosa whole tree: A narrative review from composition to health applicability

Production and Characterization of Chitooligosaccharides: Evaluation of Acute Toxicity, Healing, and Anti-Inflammatory Actions

Impact of processing, packages, and storage on quality of mangaba ( Hancornia speciosa Gomes) jelly

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