Manejo anestésico de feocromocitoma productor de dopamina

Herrero, R. López; Jiménez, Rafael Pérez; Quirós, Belén Sánchez

doi:10.1016/j.redar.2020.12.013

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…In some usual diseases, DA concentration levels are higher than in a healthy state if the measurements are made in urine samples, reaching values up to 2.5 μM [ 108 ]. An OFET with an extended-gate electrode covered by a DA receptor always represents a solution.…”

Section: Dopamine Biosensors With Organic Transistorsmentioning

confidence: 99%

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

Ravariu

2023

Biosensors

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Neurotransmitters are an important category of substances used inside the nervous system, whose detection with biosensors has been seriously addressed in the last decades. Dopamine, a neurotransmitter from the catecholamine family, was recently discovered to have implications for cardiac arrest or muscle contractions. In addition to having many other neuro-psychiatric implications, dopamine can be detected in blood, urine, and sweat. This review highlights the importance of biosensors as influential tools for dopamine recognition. The first part of this article is related to an introduction to biosensors for neurotransmitters, with a focus on dopamine. The regular methods in their detection are expensive and require high expertise personnel. A major direction of evolution of these biosensors has expanded with the integration of active biological materials suitable for molecular recognition near electronic devices. Secondly, for dopamine in particular, the miniaturized biosensors offer excellent sensitivity and specificity and offer cheaper detection than conventional spectrometry, while their linear detection ranges from the last years fall exactly on the clinical intervals. Thirdly, the applications of novel nanomaterials and biomaterials to these biosensors are discussed. Older generations, metabolism-based or enzymatic biosensors, could not detect concentrations below the micro-molar range. But new generations of biosensors combine aptamer receptors and organic electrochemical transistors, OECTs, as transducers. They have pushed the detection limit to the pico-molar and even femto-molar ranges, which fully correspond to the usual ranges of clinical detection of human dopamine in body humors that cover 0.1 ÷ 10 nM. In addition, if ten years ago the use of natural dopamine receptors on cell membranes seemed impossible for biosensors, the actual technology allows co-integrate transistors and vesicles with natural receptors of dopamine, like G protein-coupled receptors. The technology is still complicated, but the uni-molecular detection selectivity is promising.

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Section: Dopamine Biosensors With Organic Transistorsmentioning

confidence: 99%

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

Ravariu

2023

Biosensors

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“…El feocromocitoma y paraganglioma son tumores de baja incidencia de 5,7-6,6 por millón de años en el período 2010-2015, son tumores neuroendocrino de células cromafines, que se originan de la cresta neural del sistema nervioso autónomo durante el desarrollo embriológico y se extiende desde la base del cráneo hasta la pelvis, la mayor parte se localiza en las glándulas suprarrenales y entre un 25% de los feocromocitomas tienen una localización extra adrenal denominándose paraganglioma se localizan en los ganglios simpáticos paravertebrales del tórax, abdomen y pelvis (Fermandois, Magdalena Altamirano, 2020) (Calissendorff & Christofer Juhlin, 2022) son histológicamente idénticos al feocromocitoma , ambos se caracterizan por secretar adrenalina, noradrenalina y algunos son productores de dopamina (Alvaro & Monrroy Tovar, 2021) (López Herrero & Rodríguez Jiménez, 2022).…”

Section: Introductionunclassified

Manejo anestésico en un paciente con feocromocitoma y paragangliomas

Blacutt¹,

Rojas²,

Orellana³

2022

Ciencia Latina

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Introducción: La feocromocitoma y paraganglioma son tumores neuroendocrinos de células cromafines de baja incidencia, la mayor parte se localiza en las glándulas suprarrenales y entre un 25% se de localización extra adrenal denominándose paraganglioma. Material y métodos: Paciente de 56 años con el diagnóstico de feocromocitoma, con sintomatología de hipertensión arterial paroxística, taquicardia, sudoración, ansiedad y con un informe de tomografía abdominal que reporta: masa de 4 x 1,8 x 3,5 centímetros localizada por detrás de la VCI compatible con un paraganglioma o feocromocitoma. Es sometida a resección del tumor con alto riesgo de desgarro de la vena cava inferior, se realizó monitorización invasiva, profundidad anestésica, administración de drogas vasoactivas para disminuir los picos de hipertensión arterial, hipotensión arterial, arritmias evitando las complicaciones y otorgando seguridad al paciente. Discusión: El manejo anestésico es un desafío por la inestabilidad hemodinámica durante el intraoperatorio. Entre los medicamentos recomendados para mayor éxito: doxazosina, sulfato de magnesio los cuales previenen la liberación de catecolaminas, la dexmedetomidina por sus efectos simpaticolíticos producen disminución de los niveles plasmáticos de norepinefrina. Conclusiones: Gracias al trabajo multidisciplinario, al avance de la tecnología y medicamentos es posible que el riesgo de la cirugía y anestesia sean más segura.

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