Mandibular Third Molar Extraction Wound Healing With and Without Platelet Rich Plasma: A Comparative Prospective Study

Dutta, Shubha Ranjan; Singh, Purnima; Passi, Deepak; Patter, Pradeep

doi:10.1007/s12663-014-0738-1

Cited by 26 publications

(17 citation statements)

References 14 publications

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“…Overall, RCTs and prospective controlled studies where PRP was compared to unassisted socket healing (negative control) tended to show greater bone volume and enhancement of bone healing, with improved bone quality and better patient‐related outcomes (Alissa, Esposito, Horner & Oliver, ; Antonello Gde, Torres do Couto, Giongo, Correa & Chagas Junior, ; Celio‐Mariano, Melo & Carneiro‐Avelino, ; Dutta, Singh, Passi & Patter, ; Gawande & Halli, ; Ogundipe, Ugboko & Owotade, ; Rutkowski, Johnson, Radio & Fennell, ; Vivek & Sripathi Rao, ) (Appendix S3). In particular, several studies reported significantly reduced pain scores and enhanced soft tissue healing up to 14 days post‐extraction (Dutta et al., ; Ogundipe et al., ; Vivek & Sripathi Rao, ) and that PRP placed in third molars’ extractions sockets positively influenced periodontal parameters on second molars (Sammartino, Tia, Marenzi, Lauro & D'Agostino, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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“…PRP is often used in clinical studies, such as application to periodontal wound healing [6], alveolar bone healing after extraction [4] [12] [13], etc. Dutta, et al reported that they used PRP in empty extraction socket of impacted mandibular third molars, and has significant improvement in soft tissue healing and bone density in extraction sockets [12]. Gawai KT, et al…”

Section: Discussionmentioning

confidence: 99%

An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects

Niimi¹,

Yoshizawa²,

Koyama³

et al. 2017

OJST

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Abstract Platelet-rich plasma (PRP) has been used as a therapeutic tool to promote wound healing, in orthopedics, dermatology, oral surgery, etc. However, the mechanisms underlying the wound healing effects of PRP remain unclear. The purpose of this study was to evaluate the effectiveness of applying PRP, particularly in the management of tooth extraction sockets. Three upper molars of Fischer rats were extracted, and blood was drawn from the hearts of other rats to prepare PRP.

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“…[22] It has also been shown in our previous study that healing of surgical sites enhanced with PRP is 2–3 times greater than that of normal surgical sites without PRP. [23] PRP accelerates wound maturity and epithelialization and hence decreases scar formation. [24] The activation of PRP to form PRP gel causes degranulation of α-granules present in the platelets, thus releasing the growth factors.…”

Section: Discussionmentioning

confidence: 99%

A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing

Dutta

Passi²,

Singh

et al. 2016

Natl J Maxillofac Surg

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Aim:The purpose of this study was to compare the efficacy of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and hydroxyapatite (HA) for reduction of pain and swelling, absence of dry socket, soft tissue healing, and bone regeneration after mandibular third molar extraction in human patients.Materials and Methods:Forty patients requiring extraction of mandibular third molars were randomly grouped as control, PRP, PRF, and HA-treated. The patients were assessed for postoperative pain, swelling, dry socket, and soft tissue healing on the 3rd, 7th, and 14th day of postoperative periods depending on the standard methods. Radiological assessment of the extraction site was done at 1, 2, and 6 months interval to compare the change in bone density in the sockets in control and treated patients.Results:Pain and swelling were less on PRP and PRF site when compared to HA and control site. PRP and PRF site showed better soft tissue healing when compared to HA and control site. Radiographic assessment showed comparatively lesser bone density values in PRP, PRF, and control site at 1, 2, and 6 months than HA site.Conclusion:Our study showed that PRP and PRF are better graft materials than HA regarding pain, swelling, dry socket, and soft tissue healing. Bone regeneration is induced promptly by HA as compared to other graft materials. However, a more elaborate study with a larger number of clinical cases is very much essential to be more conclusive regarding the efficacy of the graft materials.

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Mandibular Third Molar Extraction Wound Healing With and Without Platelet Rich Plasma: A Comparative Prospective Study

Abstract: Aims To evaluate the efficacy of autologous platelet rich plasma (PRP) in regeneration of bone and to assess clinical compatibility of the material in mandibular third molar extraction socket.

Cited by 26 publications

References 14 publications

The use of bioactive factors to enhance bone regeneration: A narrative review

The use of bioactive factors to enhance bone regeneration: A narrative review

An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects

A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing

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