Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones

Gomes, Natália Amanda; Guarenghi, Gabriel Guidio; Valenga, Henrique Meister; Warnavin, Stephanie von Stein Cubas; Chaves, João Daniel Paganella; Cardoso, A; Steffens, João Paulo

doi:10.1016/j.archoralbio.2020.105000

Cited by 4 publications

(2 citation statements)

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“…Considering that the test used was not specific for bone AP, and that this enzyme can be found in several different tissues, this could have influenced the results. Other studies have also reported no significant AP changes after orchiectomy in the literature [ 30 ]. Although ORQ had a higher serum calcium and phosphorus concentration, the differences were not statistically significant either ( Figure 2 ).…”

Section: Discussionmentioning

confidence: 96%

Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

et al. 2021

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This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic®) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). Our results show that orchiectomy could significantly change the blood lipid profile and decrease bone integrity parameters. Testosterone reposition alone could improve some endpoints, including LDL, TC, bone weight, and bone calcium concentration. However, other parameters were not significantly improved. Co-treatment with PAO or GRA improved the blood lipid profile and bone integrity more significantly and improved some endpoints not affected by testosterone reposition alone (such as TG levels and trabeculae sizes). The results suggest that co-treatment with annatto products improved the blood lipid profile and the anti-osteoporosis effects of testosterone. Overall, GRA had better results than PAO.

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Section: Discussionmentioning

confidence: 96%

Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

et al. 2021

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“…Consequently, hormonal replacement therapy maintained alveolar bone height [ 26 ] and increased mandibular bone mineral density in male rats [ 26 ]. As estradiol showed a higher impact on maintaining mandibular bone mineral density than T in male rats, different pathways are suggested [ 28 ]. So far there is only one human study investigating the association of sex steroid hormones and bone graft regeneration in oral surgery demonstrating a significant positive association of E2 on the rate of NBF after sinus floor augmentation in men [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

et al. 2022

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Purpose The present prospective study evaluates the association between new bone formation rate in the iliac onlay graft and sex steroid hormone serum levels. Methods A total of 15 partially or completely edentulous postmenopausal females and 9 males with less than 5 mm height of the remaining alveolar bone underwent iliac onlay grafting followed by dental implant placement using a two-stage approach. Sex hormone binding globulin and 17β-estradiol serum levels were investigated by electrochemiluminescence immunoassay, while total testosterone level was analyzed using radioimmunoassay. At the time of implant placement, 12 weeks after grafting, bone biopsies were obtained and analyzed histomorphometrically. Statistical analysis was performed using linear mixed models. Results Grafting procedure was successfully performed in all patients. The mean new bone formation rate was 32.5% (116 samples). In men the mean new bone formation rate (38.1%) was significantly higher (p < 0.01) than in women (27.6%). Independent of gender 17β-estradiol and testosterone were positively associated to overall new bone formation rate, albeit a significant influence was only seen for 17β-estradiol in men (p = 0.020). Sex hormone binding globulin had no influence on new bone formation rate (p = 0.897). There was no significant association between new bone formation rate and age (p = 0.353) or new bone formation rate and body mass index (p = 0.248). Conclusion Positive association of 17ß-estradiol as well as testosterone with new bone formation rate after iliac onlay grafting indicates a role of sex steroid hormones in alveolar bone regeneration, although the observed influence was only significant for 17ß-estradiol in men. Graphical Abstract

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The role of hypoestrogenism on Mmp-8 and Mmp-13 gene expression in maxilla and mandible’s growth sites

Calixto

Omory

Ramazzotto

et al. 2022

Clinical and Investigative Orthodontics

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Mandibular-related bone metabolism in orchiectomized rats treated with sex hormones

Cited by 4 publications

References 51 publications

Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

The role of hypoestrogenism on Mmp-8 and Mmp-13 gene expression in maxilla and mandible’s growth sites

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