Mandibular Periostitis Ossificans in Immature Large Breed Dogs: 5 Cases (1999–2006)

Abstract

This case series describes clinical, radiographic, and histopathological features of mandibular swellings in 5 immature, large breed dogs. The dogs originated from different regions of the United States. In each case, intraoral dental radiography of the jaw swelling revealed a two-layered (double) ventral mandibular cortex. Biopsy was performed in 4 of the 5 puppies, revealing periosteal new bone formation. Resolution of the mandibular swelling was spontaneous in the 4 dogs available for follow-up examination. The authors postulate that the clinical, radiographic, and histopathological presentation of mandibular swelling in these 5 dogs is a distinct pathological entity consistent with an inflammatory condition of the maturing human mandible known as periostitis ossificans.

Bilateral fibrodysplasia ossificans affecting the masticatory muscles and causing irreversible trismus in a domestic shorthair cat

“…Mandibular periostitis ossificans is a condition that has been described in young people and dogs, characterised by periosteal new bone formation, without any intramuscular heterotopic lesions, and mostly related to mandibular maturation. 24 Lesions are mainly distributed along the caudal ventral border of the body of the mandible, and are suspected to be associated with dental disease in young patients. 24…”

“…24 Lesions are mainly distributed along the caudal ventral border of the body of the mandible, and are suspected to be associated with dental disease in young patients. 24…”

“…2,22,23 Mandibular periostitis ossificans is a condition that has been described in young people and dogs, characterised by periosteal new bone formation, without any intramuscular heterotopic lesions, and mostly related to mandibular maturation. 24 Lesions are mainly distributed along the caudal ventral border of the body of the mandible, and are suspected to be associated with dental disease in young patients. 24 Periosteal bone proliferation in the present case follows the muscle attachments along the temporal and parietal bones and the ramus while sparing the caudal ventral border of the body of the mandible.…”

“…24 Lesions are mainly distributed along the caudal ventral border of the body of the mandible, and are suspected to be associated with dental disease in young patients. 24 Periosteal bone proliferation in the present case follows the muscle attachments along the temporal and parietal bones and the ramus while sparing the caudal ventral border of the body of the mandible. Similar descriptions involving various locations, including the masticatory muscle attachments, are well described in humans with FOP.…”

“…Periosteal new bone formation was described in human and canine myositis ossificans circumscripta. [22][23][24][25][26][27][28][29] The lack of consistent inflammatory features on biopsied material and the bilateral multifocal asymmetric distribution of lesions are not compatible with myositis ossificans circumscripta. 22,[27][28][29] Reference Breed Table 1 (Continued)…”