Mandibular metastasis of primary extrahepatic biliary carcinoma: Case report

Dall’Magro, Alessandra Kuhn; Dogenski, Letícia Copatti; Bade, Patrícia; Cé, Larissa Cunha; Dall’Magro, Eduardo; Carli, João Paulo De

doi:10.1016/j.ijscr.2022.107498

Cited by 2 publications

(3 citation statements)

References 15 publications

(25 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Oral cavity metastasis typically has a poor prognosis, with most patients dying within one year of diagnosis (35)(36)(37)(38)(39)(40)(41)(42)(43). The prognosis depends on the treatment of the oral cavity lesion, as well as adequate control of the primary tumor and metastasis (advanced disease) (35)(36)(37)(38)(39)(40)(41)(42)(43)52). In the present case, the patient was diagnosed with extensive GBC metastasis throughout the body, and the patient's condition had deteriorated significantly by the time of admission to the Department of Internal Medicine of the University of the Ryukyus Hospital (Nishihara, Japan).…”

Section: Discussionmentioning

confidence: 99%

“…The subsequent literature review primarily focused on studies published in English, although those published in other languages were also evaluated for relevance and new information. No restrictions regarding the publication date were applied, with the earliest study being published in 1961, and the findings of the literature search were summarized in Table II (35)(36)(37)(38)(39)(40)(41)(42)(43).…”

Section: Literature Search Strategy Multiple Databases Includingmentioning

confidence: 99%

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Metastatic gallbladder cancer presenting as numb chin syndrome: A case report and literature review

Murahashi,

Ntege,

Ide

et al. 2024

Biomed Rep

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Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months. No other systemic symptoms were observed. Immunocytochemical examination revealed the presence of an adenocarcinoma and TNM staging as per the Union for International Cancer Control and the American Joint Committee on Cancer guidelines confirmed stage IVb GBC. Comprehensive full-body positron emission tomography-computed tomography examination using 18 F-fluoro-2-deoxy-D-glucose revealed additional bone and soft-tissue metastases. Palliative chemotherapy and radiation treatment were initiated based on the advanced stage of disease at the time of diagnosis. However, the patient succumbed to multiple organ failure six months later. The simultaneous occurrence of GBC, mandibular metastasis and NCS is rare and associated with poor prognosis. Despite the widespread nature of the disease, it can often manifest as non-specific oral symptoms without any systemic indications. The current study emphasizes the critical importance of timely confirmatory testing for accurate diagnosis and initiation of appropriate management for such complex conditions.

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